Molecules, Vol. 27, Pages 7423: Synthesis and Antioxidative Properties of 1,2,3,4-Tetrahydropyridine Derivatives with Different Substituents in 4-Position
Molecules, Vol. 27, Pages 7423: Synthesis and Antioxidative Properties of 1,2,3,4-Tetrahydropyridine Derivatives with Different Substituents in 4-Position
Molecules doi: 10.3390/molecules27217423
Authors:
Daniele Aiello
Hendrik Jonas
Anna Carbone
Daniela Carbone
Camilla Pecoraro
Luisa Tesoriere
Jens Köhler
Bernhard Wünsch
Patrizia Diana
Natural products are an excellent source of inspiration for the development of new drugs. Among them, betalains have been extensively studied for their antioxidant properties and potential application as natural food dyes. Herein, we describe the seven-step synthesis of new betalamic acid analogs without carboxy groups in the 2- and 6-position with an overall yield of ~70%. The Folin–Ciocalteu assay was used to determine the antioxidant properties of protected intermediate 21. Additionally, the five-step synthesis of betalamic acid analog 35 with three ester moieties was performed. Using NMR techniques, the stability of the obtained compounds towards oxygen was analyzed.
Source: Molecules - Category: Chemistry Authors: Daniele Aiello Hendrik Jonas Anna Carbone Daniela Carbone Camilla Pecoraro Luisa Tesoriere Jens K öhler Bernhard W ünsch Patrizia Diana Tags: Article Source Type: research