Mucoepidermoid Carcinoma of the Palate in Adolescence
ConclusionThe PD‐L1 positivity does not seem to have prognostic value. However, a proportion of patients with sinonasal SCC and ITAC may benefit from therapy with immune checkpoint inhibitors that recently have been approved for clinical application in head and neck cancer.
Adding sorafenib to transcatheter arterial chemoembolization (TACE) for patients with unresectable hepatocellular carcinoma (HCC) significantly improved several outcomes.Medscape Medical News
We have read your article by Singal et al1 with great interest, which discussed hepatocellular carcinoma screening being associated with early tumor detection and improved survival among patients with cirrhosis in the United States. The study clearly highlighted the importance of performing hepatocellular carcinoma screening in patient s with cirrhosis; however, what is of concern is that more than half of the cases of hepatocellular carcinoma were found secondary to symptoms or incidentally, rather than through the hepatocellular carcinoma screening algorithm.
The objective of this study was to characterize the clinicopathological prognostic factors and treatment patterns for small cell carcinoma (SCC) of the colon, a rare disease without standard treatment guidelines.MethodsWe analyzed clinicopathological and treatment variables for 503 cases of histologically proven SCC colon entered into the National Cancer Database (NCDB) between 2004 and 2013. Survival curves were generated using Kaplan-Meier and compared by the log-rank test. Cox proportional hazard regression was used to control for covariates and evaluate the effect of different treatment modalities on overall survival.R...
We examined NLR at baseline and 6 ( ±2) weeks later in 142 patients treated between 2009 and 2017 at Dana-Farber Cancer Institute (Boston, USA). Landmark analysis at 6 weeks was conducted to explore the prognostic value of relative NLR change on overall survival (OS), progression-free survival (PFS), and objective response rate (ORR ). Cox and logistic regression models allowed for adjustment of line of therapy, number of IMDC risk factors, histology and baseline NLR.ResultsMedian follow up was 16.6 months (range: 0.7–67.8). Median duration on therapy was 5.1 months (
ConclusionsA high number of PD‐1+ TILs can serve as a potent biomarker for adopting CIK cells therapy in HCC patients after curative resection.This article is protected by copyright. All rights reserved.
BackgroundInflammation and cell‐mediated immunity have a key role in different stages of carcinogenesis. The aim of this prospective study was to assess serum levels of proinflammatory cytokines interleukin‐6 (IL‐6), interleukin‐8 (IL‐8), soluble interleukin‐2 receptor (sIL‐2R), tumor necrosis factor alpha (TNF‐α), and MHC class I polypeptide‐related sequence B (MICB) in patients with oral premalignant lesion (OPL), oral squamous cell carcinoma (OSCC), and healthy controls in a multi‐biomarker approach as a potential diagnostic and prognostic tool for OSCC. Material and MethodsA total of 205 patie...
ConclusionsAAM have worse OS compared to CM with pSCC and this may partly be due to advanced stage at presentation. Treatment disparity may also contribute to lessened survival in AAM, but we were unable to demonstrate a significant difference in treatment utilisation between the groups.
Summary Nevoid basal cell carcinoma syndrome (NBCCS), also known as Gorlin Syndrome, affects only 1 in 56 000 people. It is usually inherited from a parent with the condition and affects both males and females equally (autosomal dominant inheritance). People with NBCCS may show characteristic features such as extra fingers or toes, irregular ribs, an unusually shaped face and large head. Tumours sometimes develop, particularly jaw cysts and basal cell carcinomas (BCCs) of the skin from which the syndrome is named. NBCCS is caused by mistakes (mutations) in a gene called PTCH1 located on the long arm of chromosome 9. P...