Nonenzymatic function of DPP4 promotes diabetes-associated cognitive dysfunction through IGF-2R/PKA/SP1/ERp29/IP3R2 pathway-mediated impairment of Treg function and M1 microglia polarization

Impairment of regulatory T (Treg) cells function is implicated in the pathogenesis of immune imbalance-mediated cognitive impairment. A complete understanding of whether and how this imbalance affect cognitive function in type 2 diabetes is lacking, and the driver affecting this imbalance remains unknown.

Source: Metabolism - Clinical and Experimental - October 24, 2022 Category: Biomedical Science Authors: Ya Hui, Zhiqiang Xu, Jiaxiu Li, Liuyu Kuang, Yuanmei Zhong, Yunyun Tang, Junjie Wei, Huimin Zhou, Tianpeng Zheng Source Type: research