CXCR4 and CD74 together enhance cell survival in response to migration-inhibitory factor in chronic lymphocytic leukemia

Chronic lymphocytic leukemia (CLL) is the most common form of leukemia in adults in Western countries. CLL is characterized by the clonal expansion of small mature CD5+CD23+ lymphocytes in the peripheral blood (PB), lymphoid organs, and bone marrow (BM) [1]. During CLL development, genomic changes occur in B cells that lead to altered apoptosis and survival pathways [2,3]. One of the underlying mechanisms driving CLL is the accumulation of malignant B cells that have escaped apoptosis [1,4]. The BM and lymphonodular microenvironment is composed of immune cells and stromal cells that enhance CLL cell survival through the production of cytokines and chemokines [5].

Source: Experimental Hematology - September 9, 2022 Category: Hematology Authors: Tharshika Thavayogarajah, Dzmitry Sinitski, Omar El Bounkari, Laura Torres-Garcia, Hadas Lewinsky, Alexander Harjung, Hong-Ru Chen, Jens Panse, Lucia Vankann, Idit Shachar, J ürgen Bernhagen, Steffen Koschmieder Tags: ARTICLE Source Type: research