Cysteinyl-maresin 3 inhibits IL-13 induced airway hyperresponsiveness through alternative activation of the CysLT < sub > 1 < /sub > receptor

CONCLUSIONS: MCTR3, but not LTD4, decreased the IL-13-induced airway hyperresponsiveness by activation of the CysLT1 receptor. The distinct actions of the two lipid mediators on the CysLT1 receptor suggest an alternative signalling pathway appearing under inflammatory conditions, where this new action of MCTR3 implicates potential to inhibit airway hyperresponsiveness in asthma.PMID:36116518 | DOI:10.1016/j.ejphar.2022.175257

Source: European Journal of Pharmacology - September 18, 2022 Category: Drugs & Pharmacology Authors: Jesper S äfholm Willem Abma Lora G Bankova Joshua A Boyce Mamdoh Al-Ameri Ann-Charlotte Orre Craig E Wheelock Sven-Erik Dahl én Mikael Adner Source Type: research