Acyloxyacyl hydrolase deficiency induces chronic inflammation and bone loss in male mice

In conclusion, the chronic inflammatory state of adult Aoah−/− mice promotes bone resorption. AOAH participates in bone metabolism, which is mainly mediated by inhibiting osteoclast differentiation. LPS may be a key mediator of the gut-bone axis, and targeting AOAH may represent a feasible strategy for the treatment of chronic inflammatory bone resorption.Key messagesAOAH knockout mice exhibited chronic inflammation mediated by LPS, and LPS may also serve as an important mediator in the regulation of bone metabolism in the gut-bone axis.AOAH regulated bone resorption by blocking the osteoclast differentiation via classical ERK and JNK pathways.rAOAH could rescue the enhanced osteoclast differentiation caused by AOAH deficiency.
Source: Journal of Molecular Medicine - Category: Molecular Biology Source Type: research