Male contraceptive development: A medicinal chemistry perspective
Eur J Med Chem. 2022 Aug 25;243:114709. doi: 10.1016/j.ejmech.2022.114709. Online ahead of print.ABSTRACTThere is a need for non-hormonal contraceptives. One area that needs further investigation is the development of male contraceptives. Comparatively little is understood about potential drug targets in men to achieve a reversible contraceptive effect. In this article, we review the need for male contraceptives and some thoughts around the characteristics of a male contraceptive and the potential development pathway. We then discuss different potential approaches to discovering male contraceptives and then highlight potential targets that have been discussed in the literature.PMID:36087385 | DOI:10.1016/j.ejmech.2022.114709
Source: European Journal of Medicinal Chemistry - Category: Chemistry Authors: Neil R Norcross Irene Georgiou Zoe C Johnston Franz S Gruber Jason R Swedlow Kevin D Read Christopher Lr Barratt Ian H Gilbert Source Type: research