A Review of Emerging Goose Astrovirus Causing Gout

Biomed Res Int. 2022 Aug 28;2022:1635373. doi: 10.1155/2022/1635373. eCollection 2022.ABSTRACTIn recent years, an infection in geese caused by goose astrovirus (GAstV) has repeatedly occurred in coastal areas of China and rapidly spread to inland provinces. The infection is characterized by joint and visceral gout and is fatal. The disease has caused huge economic losses to China's goose industry. GAstV is a nonenveloped, single-stranded, positive-sense RNA virus. As it is a novel virus, there is no specific classification. Here, we review the current understanding of GAstV. The virus structure, isolation, diagnosis and detection, innate immune regulation, and transmission route are discussed. In addition, since GAstV can cause gout in goslings, the possible role of GAstV in gout formation and uric acid metabolism is discussed. We hope that this review will inform researchers to rapidly develop effective methods to prevent and treat this disease.PMID:36072471 | PMC:PMC9441354 | DOI:10.1155/2022/1635373
Source: Biomed Res - Category: Research Authors: Source Type: research