Lanceolanone A, a new biflavanone, and a chalcone glucoside from the flower heads of Coreopsis lanceolata and their aldose reductase inhibitory activity and AMPK activation

AbstractThe MeOH extract of the flower heads ofCoreopsis lanceolata L. (Asteraceae) exhibited aldose reductase (AR) inhibitory activity (IC50 8.36  µg/mL). Bioassay-guided fractionation of the extract resulted in the isolation of a new biflavanone-named Lanceolanone A (1) and a chalcone glucoside (6), along with 12 known compounds (2–5 and7–14), of which4,7,9,10, and12 were isolated fromC. lanceolata for the first time. The structures of the new compounds (1 and6) were determined by extensive spectroscopic analysis, including two-dimensional (2D) NMR, and ECD calculation method. Compounds2,4,11,13, and14 exhibited AR inhibitory activities with IC50 values between 2.40 and 9.99  µM. Furthermore,8–13 at 1.0  mM activated AMPK expression in HepG2 human hepatoma cells compared to the control.Graphical abstract
Source: Journal of Natural Medicines - Category: Drugs & Pharmacology Source Type: research