E3 ubiquitin ligase Trim33 ubiquitylates Annexin A2 to promote NF- κB induced skin inflammation in psoriasis

Tripartite motif-containing protein 33, a member of the TRIM E3 ligase family, is shown to be involved in tumorigenesis, cell proliferation and inflammation. Alteration of several TRIM family proteins in psoriatic epidermis has been shown to participate in psoriasis pathogenesis. However, little is known about Trim33 expression and its role in psoriasis.

Source: Journal of Dermatological Science - September 6, 2022 Category: Dermatology Authors: Jie Zhang, Jiuling Zhu, Xiaowen Chen, Haibin Xia, Luting Yang Source Type: research