Advanced Glycation End Products: Do They Impair Bone Health in Diabetes?
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-1903-1752In diabetes mellitus (DM), there is increased formation and accumulation of
advanced glycation end products (AGEs), which represent a heterogeneous class of
molecules produced by non-enzymatic glycation of various molecules during
long-term hyperglycaemia. Several studies have examined the role of AGEs in DM
complications. Accumulating evidence suggests that AGEs affect bone metabolism.
New knowledge indicates that they may play a role in bone disease among DM
subjects. More data are now needed to clarify their role and to explore new
AGEs-based therapeutic options for optimal bone health in DM. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text
Source: Experimental and Clinical Endocrinology and Diabetes - Category: Endocrinology Authors: Papachristou, Stella Rizzo, Manfredi Papanas, Nikolaos Tags: Editorial Source Type: research