The pre-exposure SARS-CoV-2-specific T cell repertoire determines the quality of the immune response to vaccination

Determinants of immune response quality to SARS-CoV-2 remain poorly defined. Saggau et al. examine spike-specific na ïve and memory T cells pre- and post-vaccination and track pre-existing memory T cell receptors. They define T cell parameters of high-quality vaccine responses and identify high pre-existing memory and low naïve T cell contributions as predictors of low-quality responses, particularly in the elde rly.

Source: Immunity - August 11, 2022 Category: Allergy & Immunology Authors: Carina Saggau, Gabriela Rios Martini, Elisa Rosati, Silja Meise, Berith Messner, Ann-Kristin Kamps, Nicole Bekel, Johannes Gigla, Ruben Rose, Mathias Vo ß, Ulf M. Geisen, Hayley M. Reid, Melike Sümbül, Florian Tran, Dennis K. Berner, Yascha Khodamoradi Tags: Article Source Type: research