Immunodeficiency syndromes differentially impact the functional profile of SARS-CoV-2-specific T cells elicited by mRNA vaccination

Many immunocompromised individuals respond poorly to mRNA vaccination and are at higher risk of developing severe COVID-19. Gao and Cai et  al. provide the single-cell landscape of SARS-CoV-2-specific T cells after mRNA vaccination and observe that the functional quality of memory T cell responses varies considerably across different immunodeficiency syndromes.

Source: Immunity - July 18, 2022 Category: Allergy & Immunology Authors: Yu Gao, Curtis Cai, David Wullimann, Julia Niessl, Olga Rivera-Ballesteros, Puran Chen, Joshua Lange, Angelica Cuapio, Ola Blennow, Lotta Hansson, Stephan Mielke, Piotr Nowak, Jan Vesterbacka, Mira Akber, Andre Perez-Potti, Takuya Sekine, Thomas R. M üll Tags: Article Source Type: research