Lung fibroblasts facilitate pre-metastatic niche formation by remodeling the local immune microenvironment

Improved understanding of how the lung stroma contributes to the development of an immunosuppressive pre-metastatic niche could potentiate new anti-cancer treatments. Here, Gong et  al. identify COX-2+ lung fibroblasts that reprogram diverse myeloid cells to be dysfunctional or immunosuppressive. Targeting COX-2+ AdvFs reduced lung metastasis and improved efficacy of immunotherapeutics.

Source: Immunity - July 30, 2022 Category: Allergy & Immunology Authors: Zheng Gong, Qing Li, Jiayuan Shi, Jian Wei, Peishan Li, Chih-Hao Chang, Leonard D. Shultz, Guangwen Ren Tags: Article Source Type: research