q value and parent energy optimization using a low voltage ionization approach increases resolution in linear ion trap mass spectrometry

AbstractIn this work, the isolation step in the linear ion trap was performed using different “q values” conditions at a low Collision Induced Dissociation (CID) energy leading to the parent ion resolution improvements, reasonably due to better ion energy distribution. According to the results, we obtained a greater resolution and mass accuracy operating in both traditional electrospray and Low Voltage Ionization (LVI) near the q value = 0.778 and with a CID energy of 10%. This effect was evaluated with low-molecular-mass compounds (skatole and arginine). The proposed optimization yielded a superior instrument performance without adding technological complexity to mass spectrometry analyses.

Source: Journal of Mass Spectrometry - July 26, 2022 Category: Chemistry Authors: Simone Madama, Ermelinda Falletta, Amir Mohammad Malvandi, Kevin Arzoni, Carlo Brogna, Marco Varelli, Matteo Bertelli, Matteo Conti, Martina Larini, Federico Guidugli, Pietro Traldi, Simone Cristoni Tags: RESEARCH ARTICLE Source Type: research