Correlation of BRAF mutational status with clinical characteristics and survival outcomes of patients with ameloblastoma: the experience of 11 Italian centres

Conclusions
Local recurrence occurs in 30% of patients with ameloblastoma. BRAFV600 mutation is associated with younger age, mandibular localisation and with unicystic ameloblastoma. Neither BRAF mutation nor microscopically positive surgical margins were associated with RFI. Further studies are needed to elucidate outcomes of this rare disease according to clinical, histopathological and comprehensive molecular features.

Source: Journal of Clinical Pathology - July 19, 2022 Category: Pathology Authors: Bonacina, R., Indini, A., Massazza, G., Rulli, E., Gianatti, A., Mandala, M., Ameloblastoma Cooperative Group, Lucca, Moneghini, Bolzoni, Rocca, Bettini, Saia, Muria, Mariani, Bardazzi, Erdini, Lodi, Gianni, Francetti, Bedogni, Spinelli, Romeo, Valentini, Tags: Original research Source Type: research