Echographic Assessment of Extraocular Muscle Response to Teprotumumab

Purpose:

To evaluate extraocular muscle response to teprotumumab using orbital echography in thyroid eye disease.

Methods:

This retrospective study included adult thyroid eye disease patients with pre- and post-teprotumumab orbital echography. Data collected included: age, Hertel measurements, clinical activity score, Gorman diplopia scores, ocular motility, and recti muscle diameters measured by echography. The patient’s more proptotic eye before treatment initiation was designated as the study orbit. Ocular motility was assessed by totaling the ductions in all 4 cardinal directions. Orbital echography was obtained pre- and post-treatment to assess response of extraocular muscle diameters.

Results:

Six patients with a mean age of 67 years were included. There was a mean improvement in proptosis of 4.3 mm in the study eye with 11/12 orbits showing improvement in globe position (p

Source: Ophthalmic Plastic and Reconstructive Surgery - July 1, 2022 Category: Opthalmology Tags: Original Investigations Source Type: research