Endothelial Dysfunction and Platelet Hyperactivation in Diabetic Complications Induced by Glycemic Variability
Horm Metab Res 2022; 54: 419-428 DOI: 10.1055/a-1880-0978The development and progression of the complications of chronic diabetes mellitus
are attributed not only to increased blood glucose levels but also to glycemic
variability. Therefore, a deeper understanding of the role of glycemic
variability in the development of diabetic complications may provide more
insight into targeted clinical treatment strategies in the future. Previously,
the mechanisms implicated in glycemic variability-induced diabetic complications
have been comprehensively discussed. However, endothelial dysfunction and
platelet hyperactivation, which are two newly recognized critical pathogenic
factors, have not been fully elucidated yet. In this review, we first evaluate
the assessment of glycemic variability and then summarise the roles of
endothelial dysfunction and platelet hyperactivation in glycemic
variability-induced complications of diabetes, highlighting the molecular
mechanisms involved and their interconnections. [...] Georg Thieme Verlag Rüdigerstraße 14, 70469 Stuttgart,
GermanyArticle in Thieme eJournals: Table of contents | Abstract | open access Full text
Source: Hormone and Metabolic Research - Category: Endocrinology Authors: Huang, Ye Yue, Long Qiu, Jiahuang Gao, Ming Liu, Sijin Wang, Jingshang Tags: Review Source Type: research