Nano-omics: nanotechnology-based multidimensional harvesting of the blood-circulating cancerome

Nature Reviews Clinical Oncology, Published online: 23 June 2022; doi:10.1038/s41571-022-00645-xLiquid biopsy assays of diverse cancer-associated molecular alterations in blood, including genomic, epigenomic, transcriptomic, proteomic and metabolomics changes, offer considerable opportunities for early detection of cancer as well as improved management of the disease. In this Perspective, the authors review key advances in liquid biopsy-based multi-omics approaches for biomarker discovery. They also introduce the ‘nano-omics’ paradigm, whereby nanotechnology tools are used to capture and enrich various cancer-derived analytes from biofluids for subsequent omics analyses, with the aim of developing novel biomarker panels for early cancer detection.
Source: Nature Reviews Clinical Oncology - Category: Cancer & Oncology Authors: Source Type: research