Genetic tracing reveals transcription factor Foxp3-dependent and Foxp3-independent functionality of peripherally induced Treg cells

Foxp3 induction in mature CD4+ T  cells gives rise to peripheral Treg (pTreg) cells that enforce tolerance to food and commensal microbes. However, the role of Foxp3 in pTreg cells and the mechanisms supporting their differentiation remain unclear. Van der Veeken et al. use genetic tracing to identify microbiota-induced pTreg cel ls and find that they have Foxp3-dependent and Foxp3-independent features.

Source: Immunity - June 13, 2022 Category: Allergy & Immunology Authors: Joris van der Veeken, Clarissa Campbell, Yuri Pritykin, Michail Schizas, Jacob Verter, Wei Hu, Zhong-Min Wang, Fanny Matheis, Daniel Mucida, Louis-Marie Charbonnier, Talal A. Chatila, Alexander Y. Rudensky Tags: Article Source Type: research