American Journal of Clinical Pathology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Artificial intelligence-based algorithms for the diagnosis of prostate cancer: A systematic review
CONCLUSIONS: The published evidence suggests that AI can be reliably used for prostate cancer detection and grading, assisting pathologists in the time-consuming screening of slides. Further technologic improvement would help widening AI's adoption in prostate pathology, as well as expanding its prognostic predictive potential.PMID:38381582 | DOI:10.1093/ajcp/aqad182 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - February 21, 2024 Category: Pathology Authors: Stefano Marletta Albino Eccher Filippo Maria Martelli Nicola Santonicco Ilaria Girolami Aldo Scarpa Fabio Pagni Vincenzo L'Imperio Liron Pantanowitz Stefano Gobbo Davide Seminati Angelo Paolo Dei Tos Anil Parwani Source Type: research

Immune checkpoint inhibitor-related colitis in patients on immunotherapy for cancer
CONCLUSIONS: Future successful management of this form of colitis relies on our comprehension of the intricate interplay between tumoral and systemic immune responses to immune checkpoint inhibitors and innovative approaches to modify these responses, along with specific immune cell populations, to preclude immune-related adverse events while achieving antitumor therapeutic outcomes.PMID:38377034 | DOI:10.1093/ajcp/aqae002 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - February 20, 2024 Category: Pathology Authors: Belinda L Sun Alexis S Elliott David Nolte Xiaoguang Sun Source Type: research

Multicolor flow cytometric immunophenotyping is highly sensitive and specific in identifying aberrant mast cells in the diagnostic workup of systemic mastocytosis
CONCLUSIONS: Flow cytometric immunophenotyping is a quick, sensitive, high-yield tool for evaluating the immunophenotype of mast cells. An abnormal FCI finding should prompt careful histologic evaluation and sensitive KIT D816V mutation testing to address the possibility of SM. CD2, CD25, and CD30 are important markers for the detection of immunophenotypic aberrancy of mast cells, and their frequencies of aberrancy differ across SM subtypes.PMID:38372648 | DOI:10.1093/ajcp/aqad187 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - February 19, 2024 Category: Pathology Authors: Okechukwu Valentine Nwogbo Hong Fang Wei Wang Jie Xu Roberto N Miranda Prithviraj Bose Chi Young Ok Jeffrey L Jorgensen L Jeffrey Medeiros Sa A Wang Source Type: research

To normalize or not?: Dilute Russell viper venom time testing
CONCLUSIONS: The lupus anticoagulant status by the dRVVT assay was not changed based on normalization. Normalization was of no clinical benefit in our patient population; therefore, there was no need for the extra calculation step. Normalization may be useful for intermethod and interlaboratory studies and not for within-method LA detection.PMID:38372653 | DOI:10.1093/ajcp/aqae004 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - February 19, 2024 Category: Pathology Authors: Yong Zhang Michael Creer Olajumoke O Oladipo Source Type: research

AmpFire HPV and ScreenFire RS HPV validation trial
CONCLUSIONS: The excellent intra- and interlaboratory reproducibility and the established clinical performance, together with the platforms' simplicity, make these assays particularly applicable to low-resource settings.PMID:38365314 | DOI:10.1093/ajcp/aqad181 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - February 16, 2024 Category: Pathology Authors: Jun Hou Jerome L Belinson Hui Du Changzhong Li Wei Zhang Lijie Zhang Yi Zhang Xinfeng Qu Ruifang Wu Source Type: research

Assessing the feasibility of a multimodal liquid biopsy for the diagnosis of HPV-associated oropharyngeal squamous cell carcinoma
CONCLUSIONS: Compared to HPV RNA ISH, HPV serology and ctHPVDNA are sensitive and highly specific biomarkers for HPV-associated OPSCC at the time of presentation.PMID:38349613 | DOI:10.1093/ajcp/aqad185 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - February 13, 2024 Category: Pathology Authors: James S Lewis Saskia Naegele Vasileios Efthymiou Mitra Mehrad Kim A Ely Tim Waterboer Krystle A Lang Kuhs Seth J Davis Kelsey Richard Dipon Das Daniel L Faden Source Type: research

Correction to: Measuring the performance of an artificial intelligence-based robot that classifies blood tubes and performs quality control in terms of preanalytical errors: A preliminary study
Am J Clin Pathol. 2024 Feb 12:aqae025. doi: 10.1093/ajcp/aqae025. Online ahead of print.NO ABSTRACTPMID:38345151 | DOI:10.1093/ajcp/aqae025 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - February 12, 2024 Category: Pathology Source Type: research

5-Hydroxymethylcytosine (5-hmC) loss is a marker of malignancy in biliary neoplasms
CONCLUSIONS: Loss of 5-hmC is not unique to intrahepatic cholangiocarcinoma among biliary carcinomas, but is a useful diagnostic marker differentiating malignancies of the biliary tree from benign mimics.PMID:38345293 | DOI:10.1093/ajcp/aqae001 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - February 12, 2024 Category: Pathology Authors: Miguel S Gonzalez-Mancera Andrew Siref Kambiz Kosari Nicholas Nissen Srinivas Gaddam Andrew Hendifar Arsen Osipov Kevin Waters Danielle Hutchings Maha Guindi Brent K Larson Source Type: research

Characterizing the role of informal payments in the delivery of pathology and clinical laboratory services
CONCLUSIONS: This represents a first step in characterizing IPs within PALM and how this practice may affect access to these services in LMICs. Specifically, the fact that faster turnaround time was the most frequently perceived reason for offering IPs uncovers a potential barrier to improving PALM capacity in these regions.PMID:38345305 | DOI:10.1093/ajcp/aqad188 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - February 12, 2024 Category: Pathology Authors: Emily H Glynn Timothy Amukele Olusegun Soge Geoffrey Baird Taryn Vian Source Type: research