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Total 78700 results found since Jan 2013.
Skin wound healing effects of (+)-syringaresinol from ginseng berry
CONCLUSION: Collectively, we demonstrated that (+)-SYR from ginseng berry, can enhance the wound healing effect by accelerating cell proliferation and skin regeneration, suggesting the potential utility of (+)-SYR for skin wound repair.PMID:37720576 | PMC:PMC10499580 | DOI:10.1016/j.jgr.2023.04.003
Source: Cell Research - September 18, 2023 Category: Cytology Authors: Jee-Hyun Hwang Yeonsoo Kang Heui-Jin Park Seolyeong Kim Su-Hyun Lee Hangun Kim Sang-Jip Nam Kyung-Min Lim Source Type: research
Ginsenoside Rk1 inhibits HeLa cell proliferation through an endoplasmic reticulum signaling pathway
CONCLUSION: These findings indicate that the toxicity of ginsenoside Rk1 in HeLa cells can be explained by the inhibition of protein synthesis in the endoplasmic reticulum and enhanced apoptosis, with YOD1 acting as a potential target for cervical cancer treatment.PMID:37720575 | PMC:PMC10499649 | DOI:10.1016/j.jgr.2023.04.004
Source: Cell Research - September 18, 2023 Category: Cytology Authors: Qiuyang Li Hang Sun Shiwei Liu Jinxin Tang Shengnan Liu Pei Yin Qianwen Mi Jingsheng Liu Lei Yu Yunfeng Bi Source Type: research
The effects of Korean Red Ginseng on heme oxygenase-1 with a focus on mitochondrial function in pathophysiologic conditions
J Ginseng Res. 2023 Sep;47(5):615-621. doi: 10.1016/j.jgr.2023.04.001. Epub 2023 Apr 8.ABSTRACTKorean Red Ginseng (KRG) plays a key role in heme oxygenase (HO)-1 induction under physical and moderate oxidative stress conditions. The transient and mild induction of HO-1 is beneficial for cell protection, mitochondrial function, regeneration, and intercellular communication. However, chronic HO-1 overexpression is detrimental in severely injured regions. Thus, in a chronic pathological state, diminishing HO-1-mediated ferroptosis is beneficial for a therapeutic approach. The molecular mechanisms by which KRG protects various...
Source: Cell Research - September 18, 2023 Category: Cytology Authors: Chang-Hee Kim Hahn Young Kim Seung-Yeol Nah Yoon Kyung Choi Source Type: research
Integration of palliative care in the management of oral squamous cell carcinoma
Bioinformation. 2023 Jan 31;19(1):1-4. doi: 10.6026/97320630019001. eCollection 2023.ABSTRACTOral Squamous cell Cancers (OSCC) is strongly associated with tobacco consumption. We here in present a case study of a OSCC patient who refused standard oncological care (SOC), to highlight the importance of integrating palliative care (PC) for improved patient outcomes. A 61 years male patient, with history of chewing tobacco for more than 20 years and diagnosed to have OSCC for 1.5 years presented with severe anaemia and a cauliflower-like growth (12 x 10 cm) in the left oral cavity and cheek with greenish-yellow discharge. Pus ...
Source: Cell Research - September 18, 2023 Category: Cytology Authors: Republica Sridhar Huwait Etimad Peter Natesan Pushparaj Gauthaman Kalamegam Source Type: research
Temporal dynamics and genomic programming of plasma cell fates
Res Sq. 2023 Sep 6:rs.3.rs-3296446. doi: 10.21203/rs.3.rs-3296446/v1. Preprint.ABSTRACTAffinity-matured plasma cells (PCs) of varying lifespans are generated through a germinal center (GC) response. The developmental dynamics and genomic programs of antigen-specific PC precursors remain to be elucidated. Using a model antigen, we demonstrate biphasic generation of PC precursors, with those generating long-lived bone marrow PCs preferentially produced in the late phase of GC response. Clonal tracing using scRNA-seq+BCR-seq in spleen and bone marrow compartments, coupled with adoptive transfer experiments, reveal a novel PC ...
Source: Cell Research - September 18, 2023 Category: Cytology Authors: Harinder Singh Godhev Kumar Manakkat Vijay Heping Xu Source Type: research
Technical optimization of spatially resolved single-cell transcriptomic datasets to study clinical liver disease
In this study, we performed spatial transcriptomics and single nucleus RNA sequencing (snRNASeq) on matched specimens from patients with either histologically normal or advanced fibrosis to establish important aspects of tissue handling, data processing, and downstream analyses of biobanked liver samples. We observed that tissue preservation technique impacts transcriptomic data, especially in fibrotic liver. Deconvolution of the spatial transcriptome using paired snRNASeq data generated a spatially resolved, single cell dataset with 24 unique liver cell phenotypes. We determined that cell-cell interactions predicted using...
Source: Cell Research - September 18, 2023 Category: Cytology Authors: Brittany Rocque Kate Guion Pranay Singh Sarah Bangerth Lauren Pickard Jashdeep Bhattacharjee Sofia Eguizabal Carly Weaver Shefali Chopra Shengmei Zhou Rohit Kohli Linda Sher Burcin Ekser Juliet A Emamaullee Source Type: research
The PML1-WDR5 axis regulates H3K4me3 marks and promotes stemness of estrogen receptor-positive breast cancer
Res Sq. 2023 Sep 8:rs.3.rs-3266720. doi: 10.21203/rs.3.rs-3266720/v1. Preprint.ABSTRACTThe alternative splicing of PML precursor mRNA gives rise to various PML isoforms, yet their expression profile in breast cancer cells remains uncharted. We discovered that PML1 is the most abundant isoform in all breast cancer subtypes, and its expression is associated with unfavorable prognosis in estrogen receptor-positive (ER+) breast cancers. PML depletion reduces cell proliferation, invasion, and stemness, while heterologous PML1 expression augments these processes and fuels tumor growth and resistance to fulvestrant, an FDA-approv...
Source: Cell Research - September 18, 2023 Category: Cytology Authors: Hung-Ying Kao Chun-Peng Pai Han Wang Neel Agarwal Joshua Adams Zhenghao Liu Darcie Seachrist Ruth Keri William Schiemann Source Type: research
Disentangling accelerated cognitive decline from the normal aging process and unraveling its genetic components: A neuroimaging-based deep learning approach
Conclusion Our deep learning model was demonstrated effective on extracting relevant neuroimaging features and predicting individual cognitive decline. We reported a novel variant (rs144614292) within the NELL1 gene. Our approach has the potential to disentangle accelerated cognitive decline from the normal aging process and to determine its related genetic factors, leveraging opportunities for early intervention.PMID:37720047 | PMC:PMC10503860 | DOI:10.21203/rs.3.rs-3328861/v1
Source: Cell Research - September 18, 2023 Category: Cytology Authors: Yulin Dai Yu-Chun Hsu Brisa S Fernandes Kai Zhang Xiaoyang Li Nitesh Enduru Andi Liu Astrid M Manuel Xiaoqian Jiang Zhongming Zhao Source Type: research
Neuroprotective potential of intranasally delivered L-myc immortalized human neural stem cells in female rats after a controlled cortical impact injury
Res Sq. 2023 Sep 5:rs.3.rs-3242570. doi: 10.21203/rs.3.rs-3242570/v1. Preprint.ABSTRACTEfficacious stem cell-based therapies for traumatic brain injury (TBI) depend on successful delivery, migration, and engraftment of stem cells to induce neuroprotection. L-myc expressing human neural stem cells (LMNSC008) demonstrate an inherent tropism to injury sites after intranasal (IN) administration. We hypothesize that IN delivered LMNSC008 cells migrate to primary and secondary injury sites and modulate biomarkers associated with neuroprotection and tissue regeneration. To test this, immunocompetent adult female rats received a c...
Source: Cell Research - September 18, 2023 Category: Cytology Authors: Mari Amirbekyan Jeffrey P Cheng Vikram Adhikarla Eleni H Moschonas Corina O Bondi Russell C Rockne Anthony E Kline Margarita Gutova Source Type: research
TrkB-mediated sustained neuroprotection is sex-specific and ER α dependent in adult mice following neonatal hypoxia ischemia
Conclusions: These observations provide evidence for a therapeutic role for DHF in which sustained recovery of memory in females is TrkB-mediated and ERα-dependent. However, the beneficial effects of DHF therapy did not include reduction of gross tissue loss but may be derived from the enhanced functioning of residual tissues in a cell-specific manner.PMID:37720039 | PMC:PMC10503864 | DOI:10.21203/rs.3.rs-3325405/v1
Source: Cell Research - September 18, 2023 Category: Cytology Authors: Vishal Chanana Margaret Hackett Nazli Deveci Nur Aycan Burak Ozaydin Nur Sena Cagatay Damla Hanalioglu Douglas B Kintner Karson Corcoran Sefer Yapici Furkan Camci Jens Eickhoff Karyn M Frick Peter Ferrazano Jon E Levine Pelin Cengiz Source Type: research
CSF1R inhibition is not specific to innate immune cells but also affects T-helper cell differentiation independently of microglia depletion
Res Sq. 2023 Sep 6:rs.3.rs-3308220. doi: 10.21203/rs.3.rs-3308220/v1. Preprint.ABSTRACTColony-stimulating factor 1 receptor (CSF1R) inhibition has been proposed as a specific method for microglia depletion. However, recent work revealed that in addition to microglia, CSF1R inhibition also affects other innate immune cells, such as peripheral monocytes and tissue-resident macrophages of the lung, liver, spleen, and peritoneum. Here, we show that this effect is not restricted to innate immune cells only but extends to the adaptive immune compartment. CSF1R inhibition alters the transcriptional profile of bone marrow cells th...
Source: Cell Research - September 18, 2023 Category: Cytology Authors: Fengyang Lei Naiwen Cui Chengxin Zhou James Chodosh Demetrios G Vavvas Eleftherios I Paschalis Source Type: research
Role of NLRP3 inflammasomes in monocyte and microglial recruitments in choroidal neovascularization
Res Sq. 2023 Sep 9:rs.3.rs-3318233. doi: 10.21203/rs.3.rs-3318233/v1. Preprint.ABSTRACTThough the pathogenesis of choroidal neovascularization (CNV) is largely unknown in age-related macular degeneration (AMD), inflammasomes may contribute to CNV development and progression. To understand the role NLRP3 inflammasomes in CNV, we used Ccr2 RFP Cx3cr1 GFP dual-reporter mice to characterize migration of Ccr2 RFP positive monocytes and Cx3cr1 GFP positive microglial cells into CNV lesions after laser-induced rupture of Bruch's membrane. MCC950 was used as NLRP3 inhibitor. Immunostaining was used to confirm localization of NLRP3...
Source: Cell Research - September 18, 2023 Category: Cytology Authors: Blake W Dieckmann Marcell E Paguaga Gary W McCollum John S Penn Imam Uddin Source Type: research
Socioeconomic inequalities in young adulthood disrupt the immune transcriptomic landscape via upstream regulators
Res Sq. 2023 Sep 5:rs.3.rs-3295746. doi: 10.21203/rs.3.rs-3295746/v1. Preprint.ABSTRACTDisparities in socio-economic status (SES) predict many immune system-related diseases, and previous research documents relationships between SES and the immune cell transcriptome. Drawing on a bioinformatically-informed network approach, we situate these findings in a broader molecular framework by examining the upstream regulators of SES-associated transcriptional alterations. Data come from the National Longitudinal Study of Adolescent to Adult Health (Add Health), a nationally representative sample of 4,543 adults in the United State...
Source: Cell Research - September 18, 2023 Category: Cytology Authors: Sudharshan Ravi Michael J Shanahan Brandt Levitt Kathleen Mullan Harris Steven W Cole Source Type: research
Modeling Gut Neuro-Epithelial Connections in a Novel Microfluidic Device
We describe the development of a two-compartment microfluidic device for modeling neuro-epithelial interactions, and apply it to form the gut's neuro-epithelial connections. The device contains epithelial and neuronal compartments connected by microgrooves. The epithelial compartment was designed for cell seeding via injection and confinement of intestinal epithelial cells derived from human intestinal organoids. We demonstrated that organoids planarized effectively and retained epithelial phenotype for over a week. In the second chamber we dissociated and cultured intestinal myenteric neurons including intrinsic primary a...
Source: Cell Research - September 18, 2023 Category: Cytology Authors: Manolo De Hoyos Xi Yu Alan Gonzalez-Suarez Arnaldo Mercado-Perez Eugene Krueger Jeric Hernandez Brooke Druliner David R Linden Arthur Beyder Sisi Chen Yaroslav Fedyshyn Alexander Revzin Source Type: research
Fibrinogen is Associated with Clinical Adverse Events in Patients with Psoriasis and Coronary Artery Disease
CONCLUSION: Elevated fibrinogen levels were associated with adverse clinical events in patients with psoriasis and CAD, especially among patients aged <60 years, those with diabetes, and those not admitted for acute cardiovascular syndrome.PMID:37719941 | PMC:PMC10505029 | DOI:10.2147/JIR.S427992
Source: Cell Research - September 18, 2023 Category: Cytology Authors: Lin Zhao Yan Zeng Lin Sun ZengLei Zhang KunQi Yang ZuoZhi Li Man Wang XianLiang Zhou WeiXian Yang Source Type: research
