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Heart failure study of multipoint pacing effects on ventriculoarterial coupling: Rationale and design of the HUMVEE trial
Cardiac resynchronization therapy (CRT) is an established therapy for symptomatic heart failure (HF). Unfortunately, many recipients remain nonresponders. Studies have revealed the potential role of multipoint pacing (MPP) in improving response and outcomes. The aim of this study is to compare the effects of MPP against those of standard biventricular pacing (BVP) on (i) ventriculoarterial coupling (VAC) and energy efficiency of the failing heart, (ii) diastolic function, (iii) quality of life, and (iv) NT‐proBNP levels and glomerular filtration rate (GFR) during a follow‐up of 13 months. HUMVEE is a single‐center, ...
Source: Annals of Noninvasive Electrocardiology - October 15, 2017 Category: Cardiology Authors: Christina Chrysohoou, Polychronis Dilaveris, Christos ‐Konstantinos Antoniou, Ioannis Skiadas, Konstantinos Konstantinou, Konstantinos Gatzoulis, Ioannis Kallikazaros, Dimitrios Tousoulis Tags: ORIGINAL ARTICLE Source Type: research

Dynamic Changes in High ‐Sensitivity Cardiac Troponin I Are Associated with Dynamic Changes in Sum Absolute QRST Integral on Surface Electrocardiogram in Acute Decompensated Heart Failure
ConclusionPatient‐specific time‐varying changes in the surface ECG scalar measure of global electrical heterogeneity, as measured by SAI QRST, and in myocardial injury as measured by hsTnI, are independently and directly associated with each other, likely reflecting a common underlying mechanism.
Source: Annals of Noninvasive Electrocardiology - June 5, 2016 Category: Cardiology Authors: Larisa G. Tereshchenko, Albert Feeny, Erica Shelton, Thomas Metkus, Andrew Stolbach, Ernest Mavunga, Shannon Putman, Frederick K. Korley Tags: Original Article Source Type: research

Dynamic Changes in High‐Sensitivity Cardiac Troponin I Are Associated with Dynamic Changes in Sum Absolute QRST Integral on Surface Electrocardiogram in Acute Decompensated Heart Failure
ConclusionPatient‐specific time‐varying changes in the surface ECG scalar measure of global electrical heterogeneity, as measured by SAI QRST, and in myocardial injury as measured by hsTnI, are independently and directly associated with each other, likely reflecting a common underlying mechanism.
Source: Annals of Noninvasive Electrocardiology - June 5, 2016 Category: Cardiology Authors: Larisa G. Tereshchenko, Albert Feeny, Erica Shelton, Thomas Metkus, Andrew Stolbach, Ernest Mavunga, Shannon Putman, Frederick K. Korley Tags: Original Article Source Type: research