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Metronidazole pharmacokinetics during rapid growth in turkeys – relation to changes in haemodynamics and drug metabolism
Whereas interspecies variation in pharmacokinetics is a commonly investigated issue, variations in drug kinetics within a species are less documented. The aim of the study was to assess the influence of age‐related changes in haemodynamics on the pharmacokinetics of metronidazole (MTZ) and its hydroxy metabolite (MTZ‐OH) in turkeys. MTZ was administered intravenously and orally at a dose of 25 mg/kg. Plasma drug and metabolite concentrations were assessed by high‐performance liquid chromatography, and pharmacokinetic parameters were calculated by noncompartmental analysis. Haemodynamic parameters (heart rate, stroke...
Source: Journal of Veterinary Pharmacology and Therapeutics - January 27, 2016 Category: Veterinary Research Authors: M. Świtała, B. Poźniak, U. Pasławska, T. Grabowski, K. Motykiewicz‐Pers, K. Bobrek Tags: Scientific Paper Source Type: research