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Potential new uses of non-vitamin K antagonist oral anticoagulants to treat and prevent stroke
Conclusion: There may be a role for NOACs in stroke prevention and treatment beyond atrial fibrillation. Randomized controlled trials are needed to compare NOACs to current stroke prevention and treatment strategies in certain subgroups of patients with cerebrovascular disease.
Source: Neurology - September 21, 2015 Category: Neurology Authors: Yaghi, S., Kamel, H., Elkind, M. S. V. Tags: Stroke prevention, All Cerebrovascular disease/Stroke, Infarction, Cerebral venous thrombosis VIEWS & amp;amp; REVIEWS Source Type: research

Quantifying Cerebral Collaterals In Carotid Artery Dissection May Help Stratify Stroke Risk. (P3.110)
CONCLUSIONS: These uncontrolled data suggest that a quantified score of distal cerebral collaterals could help stratify stroke risk and help guide management in patients with carotid artery dissection. Further controlled, prospective study in a larger and more diverse sample is warranted.Study Supported by: AHA/ASA NCRP 13CRP14140001Disclosure: Dr. Southerland has received personal compensation in an editorial capacity for Neurology Podcast. Dr. Gaughen has received personal compensation for activities with Covidien Neurovascular, Microvention, and Stryker Neurovascular as a consultant. Dr. McMurry has nothing to disclose....
Source: Neurology - April 9, 2014 Category: Neurology Authors: Southerland, A., Gaughen, J., McMurry, T., Wintermark, M., Majersik, J., Worrall, B. Tags: Cerebrovascular Disease and Interventional Neurology: Large Vessel Nonatherosclerotic Arteriopathies Source Type: research

Ischemic Stroke And Cervical Artery Dissection. Risk Factors And Functional Outcome In a Single Tertiary Care Hospital: The Clinica Alemana Stroke Registry (RECCA), 1997-2003 (P3.111)
ConclusionsThe prognosis of ischemic stroke patients with cervical artery dissections is generally good. The only variable associated with a worse prognosis, was a high NIHSS at admission. This allows early identification of a group of patients who are at increased risk of significant disability at discharge.Disclosure: Dr. Diaz has nothing to disclose. Dr. Vicuña has nothing to disclose. Dr. Fernandez has nothing to disclose. Dr. Valenzuela has nothing to disclose. Dr. Lavados has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Diaz, V., Vicuna, M., Fernandez, J., Valenzuela, M., Lavados, P. Tags: Cerebrovascular Disease and Interventional Neurology: Large Vessel Nonatherosclerotic Arteriopathies Source Type: research

Cervical Artery Dissections in the Vancouver General Hospital (VGH) Stroke Database: A common stroke mechanism? (P5.161)
Conclusion: In this preliminary review, we have identified 26 patients with CAD in the first 6 months of our database collection. Although these results are from a single centre, this incidence of cervical artery dissection is much higher than expected. This analysis is ongoing and we will assess race-ethnicity, presenting features and preceding history of trauma and infection.Disclosure: Dr. Wilson has nothing to disclose. Dr. Salmeen has nothing to disclose. Dr. Field has received personal compensation in an editorial capacity for Postgraduate Medicine. Dr. Yip has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Wilson, L., Salmeen, A., Field, T., Yip, S. Tags: Cerebrovascular Disease and Interventional Neurology: Dissection Source Type: research

Ischemic Stroke in Pregnancy and Postpartum: A Descriptive Case Series (P1.079)
CONCLUSIONS: In our series of 19 pregnancy-associated ischemic strokes, mechanisms appeared unrelated to traditional vascular risk factors, and there was a substantial proportion of poor outcomes. Strokes were commonest in the 12 weeks postpartum, almost one third of which occurred following a miscarriage. Further exploration with a larger cohort is planned.Disclosure: Dr. Miller has nothing to disclose. Dr. Yaghi has nothing to disclose. Dr. Boehme has nothing to disclose. Dr. Willey has nothing to disclose. Dr. Elkind has received personal compensation for activities with BMS-Pfizer Partnership, Janssen Pharmaceuticals, ...
Source: Neurology - April 8, 2015 Category: Neurology Authors: Miller, E., Yaghi, S., Boehme, A., Willey, J., Elkind, M., Marshall, R. Tags: Cerebrovascular Disease and Interventional Neurology: Epidemiology Source Type: research

Unusual Intersection: Elucidating the Role of Erdheim Chester Disease in Stroke (P4.366)
Conclusion:A unifying diagnosis of ECD was identified for this gentleman presenting with a stroke in the setting of critical ICA stenosis. Pathology from his CEA suggests that while ECD involves multisystem inflammation, it did not appear to play a direct role in his stroke.Disclosure: Dr. Sheikhi has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Sheikhi, L. Tags: Cerebrovascular Case Reports Source Type: research

Cervical artery dissection: Trauma and other potential mechanical trigger events
Conclusion: PCT seems to be an important environmental determinant of CeAD, but was not an independent outcome predictor. Because of the characteristics of most PCTs, the term mechanical trigger event rather than trauma may be more appropriate.
Source: Neurology - May 20, 2013 Category: Neurology Authors: Engelter, S. T., Grond-Ginsbach, C., Metso, T. M., Metso, A. J., Kloss, M., Debette, S., Leys, D., Grau, A., Dallongeville, J., Bodenant, M., Samson, Y., Caso, V., Pezzini, A., Bonati, L. H., Thijs, V., Gensicke, H., Martin, J. J., Bersano, A., Touze, E., Tags: Stroke in young adults, Other trauma, Carotid artery dissection ARTICLE Source Type: research

Stroke Due To Extracranial Internal Carotid Artery Dissection After Roller Coaster Rides In A 4-Year-Old Boy (P7.343)
CONCLUSIONS: To our knowledge this is the youngest patient with stroke secondary to ICA dissection following roller-coaster rides. Although the exact mechanism of injury leading to ICA dissection in the setting of sudden linear acceleration, deceleration and rotational forces such as those experienced while riding a roller coaster is not fully understood, these injuries have been attributed to brief sustained excessive gravitational forces likely augmented among predisposed individuals. Children may be at higher risk due to the immature anatomy of their cervical spine. Alterations to roller coaster ride dynamics and use of...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Nouh, A., Vela-Duarte, D., Grobelny, T., Hoganson, G., Pasquale, D., Biller, J. Tags: Child Neurology and Developmental Neurology VI Source Type: research

Clinical import of Horner syndrome in internal carotid and vertebral artery dissection
Conclusion: In patients with ICAD, HS is an easily assessable marker that might indicate a more benign clinical course. HS had no prognostic meaning in patients with VAD.
Source: Neurology - May 5, 2014 Category: Neurology Authors: Lyrer, P. A., Brandt, T., Metso, T. M., Metso, A. J., Kloss, M., Debette, S., Leys, D., Caso, V., Pezzini, A., Bonati, L. H., Thijs, V., Bersano, A., Touze, E., Gensicke, H., Martin, J. J., Lichy, C., Tatlisumak, T., Engelter, S. T., Grond-Ginsbach, C., F Tags: Stroke in young adults, Carotid artery dissection ARTICLE Source Type: research

Endovascular management and outcome of acute middle cerebral artery stroke in the setting of spontaneous carotid dissection (P1.012)
Conclusion: This study provides additional evidence that endovascular management of carotid artery dissection in acute middle cerebral artery is effective and safe to maintain distal revascularization. Revascularization can be achieved with a combination of stenting, large catheter mediated angioplasty and thrombectomy. Further studies are warranted to investigate the role of endovascular recanalization for this stroke subtypeDisclosure: Dr. Gulati has nothing to disclose. Dr. Aghaebrahim has nothing to disclose. Dr. Ducruet has nothing to disclose. Dr. Jankowitz has nothing to disclose. Dr. Jovin has received personal com...
Source: Neurology - April 8, 2015 Category: Neurology Authors: Gulati, D., Aghaebrahim, A., Ducruet, A., Jankowitz, B., Jovin, T., Jadhav, A. Tags: Cerebrovascular Disease and Interventional Neurology I ePosters Source Type: research

Sensitivity to acute cerebral ischemic injury in migraineurs: A retrospective case-control study
Conclusions: This case-control study supports the hypothesis that a history of migraine, particularly with aura, is associated with a no-mismatch pattern during acute ischemic stroke, consistent with data obtained in migraine mutant mice.
Source: Neurology - November 30, 2015 Category: Neurology Authors: Mawet, J., Eikermann-Haerter, K., Park, K.-Y., Helenius, J., Daneshmand, A., Pearlman, L., Avery, R., Negro, A., Velioglu, M., Arsava, E. M., Ay, H., Ayata, C. Tags: Migraine, All Cerebrovascular disease/Stroke ARTICLE Source Type: research

Intraarterial Treatment for Acute Ischemic Stroke: Analysis of Outcomes of Dissection vs. Non-Dissection Mechanism in 445 patients (P4.380)
Conclusions: Intraarterial treatment appears to be as safe and effective when used in patients with ischemic stroke due to CAD as in AIS patients with other causes. Following the major advances in IAT for AIS in the general population, IAT should be considered in patients with AIS due to a CAD.Disclosure: Dr. Jensen has nothing to disclose. Dr. Salottolo has nothing to disclose. Dr. McCarthy has nothing to disclose. Dr. Loy has nothing to disclose. Dr. Frei has received personal compensation for activities with Microvention, Covidien, Stryker, Siemens, and Penumbra as a consultant. Dr. Wagner has received personal compensa...
Source: Neurology - April 3, 2016 Category: Neurology Authors: Jensen, J., Salottolo, K., McCarthy, K., Loy, D., Frei, D., Wagner, J., Whaley, M., Bar-Or, D. Tags: Non-Atherosclerotic Arteriopathies Source Type: research

Familial occurrence and heritable connective tissue disorders in cervical artery dissection
Conclusions: In this largest series of patients with CeAD to date, family history of symptomatic CeAD was rare and inherited connective tissue disorders seemed exceptional. This finding supports the notion that CeAD is a multifactorial disease in the vast majority of cases.
Source: Neurology - November 24, 2014 Category: Neurology Authors: Debette, S., Goeggel Simonetti, B., Schilling, S., Martin, J. J., Kloss, M., Sarikaya, H., Hausser, I., Engelter, S., Metso, T. M., Pezzini, A., Thijs, V., Touze, E., Paolucci, S., Costa, P., Sessa, M., Samson, Y., Bejot, Y., Altintas, A., Metso, A. J., H Tags: Stroke in young adults, All Cerebrovascular disease/Stroke, Carotid artery dissection, Risk factors in epidemiology, All Genetics ARTICLE Source Type: research

Cervical artery dissection in patients >=60 years: Often painless, few mechanical triggers
Conclusion: In our study population of patients diagnosed with CeAD, 1 in 14 was aged ≥60 years. In these patients, pain and mechanical triggers might be missing, rendering the diagnosis more challenging and increasing the risk of missed CeAD diagnosis in older patients.
Source: Neurology - April 3, 2017 Category: Neurology Authors: Traenka, C., Dougoud, D., Simonetti, B. G., Metso, T. M., Debette, S., Pezzini, A., Kloss, M., Grond-Ginsbach, C., Majersik, J. J., Worrall, B. B., Leys, D., Baumgartner, R., Caso, V., Bejot, Y., Compter, A., Reiner, P., Thijs, V., Southerland, A. M., Ber Tags: Stroke in young adults, All Cerebrovascular disease/Stroke, Carotid artery dissection ARTICLE Source Type: research

Connective tissue anomalies in patients with spontaneous cervical artery dissection
Conclusions: Connective tissue abnormalities are frequent in patients with sCeAD. This reinforces the hypothesis that systemic aberrations of the connective tissue might be implicated in the pathogenesis of the disease.
Source: Neurology - November 24, 2014 Category: Neurology Authors: Giossi, A., Ritelli, M., Costa, P., Morotti, A., Poli, L., Del Zotto, E., Volonghi, I., Chiarelli, N., Gamba, M., Bovi, P., Tomelleri, G., Carletti, M., Checcarelli, N., Meneghetti, G., Morra, M., Chinaglia, M., De Giuli, V., Colombi, M., Padovani, A., Pe Tags: Stroke in young adults, Carotid artery dissection, Risk factors in epidemiology ARTICLE Source Type: research

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