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Total 793 results found since Jan 2013.
Managing competing demands in the implementation of response‐adaptive randomization in a large multicenter phase III acute stroke trial
It is well known that competing demands exist between the control of important covariate imbalance and protection of treatment allocation randomness in confirmative clinical trials. When implementing a response‐adaptive randomization algorithm in confirmative clinical trials designed under a frequentist framework, additional competing demands emerge between the shift of the treatment allocation ratio and the preservation of the power. Based on a large multicenter phase III stroke trial, we present a patient randomization scheme that manages these competing demands by applying a newly developed minimal sufficient balancin...
Source: Statistics in Medicine - May 22, 2014 Category: Statistics Authors: Wenle Zhao, Valerie Durkalski Tags: Research Article Source Type: research
Clinical Significance of Hyperdense Lesions on Non-enhanced Brain CT Obtained Immediately after Arterial Revascularization in Acute Ischemic Stroke Patients
CONCLUSION: Hyperdense lesions on non-enhanced brain CT obtained immediately after arterial revascularization (AR) exhibited varying features. Type I indicated a pure contrast extravasation. Type II and type III hyperdense lesions suggested higher incidence of HT, the presence of type III lesions indicated an ominous outcome.PMID:34527073 | PMC:PMC8437617 | DOI:10.1155/2021/1562502
Source: Computational and Mathematical Methods in Medicine - September 16, 2021 Category: Statistics Authors: Changbin Wang Zudong Yin Xinyi Zhang Xiumin Zhao Source Type: research
Integrative Analyses of Biomarkers Associated with Endoplasmic Reticulum Stress in Ischemic Stroke
CONCLUSIONS: By integrating and analyzing the two gene expression data profiles, it can be inferred that ERS may be involved in the development of neuronal apoptosis following IS via immune homeostasis. The identified hub genes, which are associated with immune cell infiltration, may serve as potential biomarkers for relative diagnosis and therapy.PMID:36060663 | PMC:PMC9436554 | DOI:10.1155/2022/4212180
Source: Computational and Mathematical Methods in Medicine - September 5, 2022 Category: Statistics Authors: Xiaoting Zhang Xi Li Jinyan Gu Jingpei Guo Jiayao Chen Ke Zhang Junfeng Liu Jiani Liu Chao Peng Hanwei Liu Bin Zhou Source Type: research
An Untargeted Lipidomics Study of Acute Ischemic Stroke with Hyperglycemia Based on Ultrahigh-Performance Liquid Chromatography-Mass Spectrometry
This study was to investigate the interrelationship between hyperglycemia and AIS and provided a reference for blood glucose management of AIS patients. The blood glucose level of AIS patients of the present study was controlled by insulin below 180 mg/dL (standard group) and between 80 and 130 mg/dL (management group). And the fasting venous blood samples were collected for determination of blood glucose level, homeostasis model assessment of insulin resistance (HOMA-IR), peptide C, and basal insulin level. Furthermore, lipids of the blood samples were detected using metabolomics, so as to clarify the similarities and dif...
Source: Computational and Mathematical Methods in Medicine - September 5, 2022 Category: Statistics Authors: Jia Guo Hailan Wang Xin Jiang Yan Wang Zhihao Zhang Qingbin Liao Jia Xu Source Type: research
Clinical Significance and Value of Serum Homocysteine and Urine 11 Dehydrothromboxane B2 Combined with Transferrin-Specific Peptide in the Diagnosis of Cerebral Apoplexy
CONCLUSION: There is imbalance between Hcy, urine 11-DH-TXB2, and TF-UP in patients with acute stroke. High Hcy, urine 11-DH-TXB2, and low TF-UP are closely related to the occurrence of cerebral infarction. Hcy, urine 11-DH-TXB2, and TF-UP may be the risk factors of stroke and positively correlated with the degree of neurological impairment. Effective monitoring of Hcy and urine 11-DH-TXB2 combined with TF-UP levels and positive intervention measures may effectively prevent the occurrence and development of cerebral infarction, reduce Hcy and urine 11-DH-TXB2, or increase the level of TF-UP, which may provide new ideas for...
Source: Computational and Mathematical Methods in Medicine - May 27, 2022 Category: Statistics Authors: Junli Liu Juan He Chang Zhang Source Type: research
Minimal sufficient balance--a new strategy to balance baseline covariates and preserve randomness of treatment allocation
In many clinical trials, baseline covariates could affect the primary outcome. Commonly used strategies to balance baseline covariates include stratified constrained randomization and minimization. Stratification is limited to few categorical covariates. Minimization lacks the randomness of treatment allocation. Both apply only to categorical covariates. As a result, serious imbalances could occur in important baseline covariates not included in the randomization algorithm. Furthermore, randomness of treatment allocation could be significantly compromised because of the high proportion of deterministic assignments associat...
Source: Statistical Methods in Medical Research - November 26, 2015 Category: Statistics Authors: Zhao, W., Hill, M. D., Palesch, Y. Tags: Articles Source Type: research
Evaluating hospital performance based on excess cause‐specific incidence
Formal evaluation of hospital performance in specific types of care is becoming an indispensable tool for quality assurance in the health care system. When the prime concern lies in reducing the risk of a cause‐specific event, we propose to evaluate performance in terms of an average excess cumulative incidence, referring to the center's observed patient mix. Its intuitive interpretation helps give meaning to the evaluation results and facilitates the determination of important benchmarks for hospital performance. We apply it to the evaluation of cerebrovascular deaths after stroke in Swedish stroke centers, using data f...
Source: Statistics in Medicine - January 16, 2015 Category: Statistics Authors: Bart Van Rompaye, Marie Eriksson, Els Goetghebeur Tags: Research Article Source Type: research
Predictive Value of Red Blood Cell Distribution Width in Poststroke Depression
CONCLUSIONS: RDW-SD is a simple, inexpensive, rapid, and easily accessible parameter that can be used to predict PSD in patients with stroke.PMID:34335867 | PMC:PMC8315889 | DOI:10.1155/2021/8361504
Source: Computational and Mathematical Methods in Medicine - August 2, 2021 Category: Statistics Authors: Ming Dai Qiyao Wei Yuxin Zhang Chuanqin Fang Ping Qu Lei Cao Source Type: research
Influence of Optimal Management of Hyperglycemia and Intensive Nursing on Blood Glucose Control Level and Complications in Patients with Postoperative Cerebral Hemorrhage
CONCLUSION: Optimal management of hyperglycemia and intensive nursing can effectively control the blood sugar level of patients after cerebral hemorrhage, reducing insulin dosage, and the occurrence of hypoglycemia, pulmonary infection, and rebleeding.PMID:36072767 | PMC:PMC9444437 | DOI:10.1155/2022/8553539
Source: Computational and Mathematical Methods in Medicine - September 8, 2022 Category: Statistics Authors: Dandan Sun Liang Sun Fang Su Source Type: research
