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Heparin-Induced Thrombocytopenia after Total Knee Replacement.
Authors: Salášek M, Šlechtová J, Pavelk T Abstract Heparin-induced thrombocytopenia is a rare complication of treatment with both unfractionated heparin (UFH) and low molecular weight heparin (LMWH). Antibodies against the complex heparin-platelet factor 4 are the main cause of pathogenesis, resulting in the activation of thrombocytes, coagulation, endothelium, monocytes, neutrophils and subsequent highly prothrombotic state. The prothrombotic state can result not only in venous but also in arterial thrombosis at different locations (which is manifested apart from venous thromboembolic disease also by acute lim...
Source: Acta Chirurgiae Orthopaedicae et Traumatologiae Cechoslovaca - May 13, 2020 Category: Orthopaedics Tags: Acta Chir Orthop Traumatol Cech Source Type: research