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Source: BMJ Open
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Total 555 results found since Jan 2013.
Intervention to reduce sedentary behaviour and improve outcomes after stroke (Get Set Go): a study protocol for the process evaluation of a pilot cluster randomised controlled trial (RECREATE)
We report the protocol for the process evaluation which will address the following objectives: (1) describe and clarify causal assumptions about the intervention, and its mechanisms of impact; (2) assess implementation fidelity; (3) explore views, perceptions and acceptability of the intervention to staff, stroke survivors and their carers; (4) establish the contextual factors that influence implementation, intervention mechanisms and outcomes.
Methods and analysis
This pilot trial will be conducted in 15 UK-based National Health Service stroke services. This process evaluation study, underpinned by the Medical Research C...
Source: BMJ Open - September 12, 2023 Category: General Medicine Authors: Johansson, J. F., Shannon, R., Mossabir, R., Airlie, J., Ozer, S., Moreau, L. A., Farrin, A., Mead, G., English, C., Fitzsimons, C. F., Clarke, D. J., Forster, A., on behalf of the RECREATE Programme Management Group, RECREATE Programme Management Group, Tags: Open access, Rehabilitation medicine Source Type: research
Systematic review and network meta-analysis comparing antithrombotic agents for the prevention of stroke and major bleeding in patients with atrial fibrillation
Conclusions
Compared with standard adjusted dose VKA, new oral anticoagulants were associated with modest reductions in the absolute risk of stroke and major bleeding. People on antiplatelet drugs experienced more strokes compared with anticoagulant drugs without any reduction in bleeding risk. To fully elucidate the comparative benefits and harms of antithrombotic agents across the various subpopulations, rigorously conducted comparative studies or network meta-regression analyses of patient-level data are required.
Systematic review registration number
PROSPERO registry—CRD42012002721.
Source: BMJ Open - June 2, 2014 Category: Journals (General) Authors: Cameron, C., Coyle, D., Richter, T., Kelly, S., Gauthier, K., Steiner, S., Carrier, M., Coyle, K., Bai, A., Moulton, K., Clifford, T., Wells, G. Tags: Open access, Cardiovascular medicine, Epidemiology, Health policy Research Source Type: research
What's in a name? The challenge of describing interventions in systematic reviews: analysis of a random sample of reviews of non-pharmacological stroke interventions
Conclusions
Most focus on intervention reporting has been directed at trials. Poor intervention reporting in stroke systematic reviews is prevalent, compounded by poor trial reporting. Without adequate intervention descriptions, the conduct, usability and interpretation of reviews are restricted and therefore, require action by trialists, systematic reviewers, peer reviewers and editors.
Source: BMJ Open - November 17, 2015 Category: Journals (General) Authors: Hoffmann, T. C., Walker, M. F., Langhorne, P., Eames, S., Thomas, E., Glasziou, P. Tags: Open access, Evidence based practice, Medical publishing and peer review, Neurology, Rehabilitation medicine Research Source Type: research
Efficacy of two injection-site localisation techniques for botulinum toxin injections: a single-blind, crossover, randomised trial protocol among adults with hemiplegia due to stroke
This study received ethics approval form the CPP of Rhônes-Alpes region. Results will be published in a peer-reviewed journal.
Trial registration number
NCT01935544; pre-results.
Source: BMJ Open - November 14, 2016 Category: Journals (General) Authors: Morel, C., Hauret, I., Andant, N., Bonnin, A., Pereira, B., Coudeyre, E. Tags: Open access, Neurology, Rehabilitation medicine Protocol Source Type: research
Validity of self-reported myocardial infarction and stroke in regions with Sami and Norwegian populations: the SAMINOR 1 Survey and the CVDNOR project
Conclusions
The sensitivity and PPV of SMI were high and moderate, respectively; for SRS, both of these measures were moderate. Our results show that SMI from the SAMINOR 1 Survey may be used in aetiological/analytical studies in this population due to a high IHD-specific PPV. The SAMINOR 1 questionnaire may also be used to estimate the prevalence of acute myocardial infarction and acute stroke.
Source: BMJ Open - November 29, 2016 Category: Journals (General) Authors: Eliassen, B.-M., Melhus, M., Tell, G. S., Borch, K. B., Braaten, T., Broderstad, A. R., Graff-Iversen, S. Tags: Open access, Epidemiology, Research methods Source Type: research
Effectiveness and safety of manual acupuncture therapy in patients with post-stroke depression: a protocol for a systematic review and meta-analysis
Introduction
Acupuncture is widely used on the rehabilitation of stroke survivors, including hemiplegia, constipation, emotional disorders and so on. Although the effectiveness of manual acupuncture therapy on post-stroke depression (PSD) has been confirmed by multiple randomised controlled trials, there were few meta-analyses focused on the connection between different techniques, durations or other detailed operations of manual acupuncture and their effectiveness of improving the depression severity and quality of life for patients with PSD.
Methods and analysis
A systematic search will be performed on English databases...
Source: BMJ Open - December 10, 2021 Category: General Medicine Authors: Liu, W., Rao, C., Zhao, Q., Du, Y., Nan, X., Li, Z., Yin, C. Tags: Open access, Complementary medicine Source Type: research
Potential effects on cardiometabolic risk factors and body composition by short message service (SMS)-guided training after recent minor stroke or transient ischaemic attack: post hoc analyses of the STROKEWALK randomised controlled trial
Conclusions
No clear effect of 3 months daily mobile phone delivered training instructions was detected on body composition, cardiovascular biochemical risk factors or self-perceived health. Further research is needed to evaluate secondary prevention efforts in larger populations after recent stroke.
Trial registration number
NCT02902367.
Source: BMJ Open - October 18, 2021 Category: General Medicine Authors: Vahlberg, B. M., Lundström, E., Eriksson, S., Holmback, U., Cederholm, T. Tags: Open access, Rehabilitation medicine Source Type: research
Cost-effectiveness of speech and language therapy plus scalp acupuncture versus speech and language therapy alone for community-based patients with Brocas aphasia after stroke: a post hoc analysis of data from a randomised controlled trial
Conclusions
Compared with speech and language therapy alone, the addition of scalp acupuncture was cost-effective in Chinese communities. As the costs of acupuncture services in China are likely to differ from other countries, these results should be carefully interpreted and remain to be confirmed in other populations.
Trial registration number
ChiCTR-TRC-13003703.
Source: BMJ Open - September 6, 2021 Category: General Medicine Authors: Liu, Z., Huang, J., Xu, Y., Wu, J., Tao, J., Chen, L. Tags: Open access, Complementary medicine Source Type: research
Protocol for the economic evaluation of the China Salt Substitute and Stroke Study (SSaSS)
This study protocol describes the planned within-trial economic evaluation of a low-sodium salt substitute intervention designed to reduce the risk of stroke in China.
Methods and analyses
The economic evaluation will be conducted alongside the Salt Substitute and Stroke Study: a 5-year large scale, cluster randomised controlled trial. The outcomes of interest are quality of life measured using the EuroQol-5-Dimensions and major adverse cardiovascular events. Costs will be estimated from a healthcare system perspective and will be sought from the routinely collected data available within the New Rural Cooperative Medical ...
Source: BMJ Open - July 20, 2021 Category: General Medicine Authors: Li, K.-C., Tian, M., Neal, B., Huang, L., Yu, J., Liu, Y., Yin, X., Zhang, X., Wu, Y., Li, N., Elliott, P., Yan, L., Labarthe, D., Hao, Z., Shi, J., Feng, X., Zhang, J., Zhang, Y., Zhang, R., Zhou, B., Li, Z., Sun, J., Zhao, Y., Yu, Y., Si, L., Lung, T. Tags: Open access, Health economics Source Type: research
What do people with lung cancer and stroke expect from patient navigation? A qualitative study in Germany
Conclusion
For chronic and complex diseases—as is the case with lung cancer and stroke—it appears less important for navigators to fulfil disease-specific tasks. Rather, they should ensure that patients’ more general needs, in relation to social, practical and emotional support, are met in a way that suits their individual wishes. Following these results, patient navigation programmes might be designed to include generic elements, which should then be adapted to the infrastructure in a particular healthcare region and to the particularities of a specific healthcare system.
Source: BMJ Open - December 23, 2021 Category: General Medicine Authors: Fügemann, H., Goerling, U., Gödde, K., Desch, A. K., Müller-Nordhorn, J., Mauckisch, V., Siegerink, B., Rieckmann, N., Holmberg, C. Tags: Open access, Qualitative research Source Type: research
Impact of interankle blood pressure difference on major adverse cardiovascular events in cryptogenic stroke patients without peripheral artery disease: a retrospective cohort study
Conclusions
Large IAND is independently associated with the long-term occurrence of MACEs in patients with CS without PAD. In particular, the association between IAND and MACEs is only valid in elderly patients.
Source: BMJ Open - February 23, 2022 Category: General Medicine Authors: Han, M., Baik, M., Kim, Y. D., Choi, J., Seo, K., Park, E., Heo, J. H., Nam, H. S. Tags: Open access, Neurology Source Type: research
Effectiveness of transcranial direct current stimulation on hand dexterity in stroke patients: a protocol for a systematic review and meta-analysis
Introduction
Hand dexterity is the ability to execute the skilful movements using the hand and fingers. It is commonly impaired poststroke resulting in a profound deterioration in the quality of life for patients with stroke. Transcranial direct current stimulation (tDCS) is a form of non-invasive brain stimulation, which has gained a popularity as an adjunct therapy in recovering motor dysfunction poststroke. Promising results have been gained from applying tDCS in combination with motor rehabilitation, however, the outcome of tDCS on the upper limb motor function poststroke has been varied. Different results are potentia...
Source: BMJ Open - February 16, 2022 Category: General Medicine Authors: Alabdulaali, L., Hickman, L., Punt, T. D., Jenkinson, N. Tags: Open access, Rehabilitation medicine Source Type: research
Effect of a tailored multidimensional intervention on the care burden among family caregivers of stroke survivors: a randomised controlled trial
Conclusion
The main results showed that participants in the IG did not experience an improvement in the main outcomes. Nevertheless, the improvement in the psychological and social domains may have been attributed to our intervention.
Trial registration number
NCT04211662.
Source: BMJ Open - February 15, 2022 Category: General Medicine Authors: Elsheikh, M. A., Moriyama, M., Rahman, M. M., Kako, M., EL-Monshed, A. H., Zoromba, M., Zehry, H., Khalil, M. H., El-Gilany, A.-H., Amr, M. Tags: Open access, Nursing Source Type: research
Feasibility of an individualised, task-oriented, video-supported home exercise programme for arm function in patients in the subacute phase after stroke: protocol of a randomised controlled pilot study
This study follows the Standard Protocol Items: Recommendations for Interventional Trials-Patient-Reported Outcome (PRO) Extension guideline. Ethical approval was received from the Ethics Committee of the Medical University of Innsbruck, Austria (1304/2020). Written informed consent will be obtained from all participants prior to data collection. Study results will be disseminated to participating patients, patient organisations, via the clinic’s homepage, relevant conferences and peer-reviewed journals.
Trial registration number
DRKS-ID: DRKS00023395.
Study protocol, second revision, 5 December 2021.
Source: BMJ Open - January 4, 2022 Category: General Medicine Authors: Wanner, M., Schönherr, G., Kiechl, S., Knoflach, M., Müller, C., Seebacher, B. Tags: Open access, Neurology Source Type: research
PCSK9 inhibition in patients with acute stroke and symptomatic intracranial atherosclerosis: protocol for a prospective, randomised, open-label, blinded end-point trial with vessel-wall MR imaging
Introduction
Dual antiplatelet therapy and high-intensity statins are the mainstay treatment in patients with acute stage, symptomatic intracranial atherosclerotic stenosis (ICAS). Alirocumab is a monoclonal antibody that can inhibit proprotein convertase subtilisin–kexin type 9 and effectively lower low-density lipoprotein cholesterol levels with less side effects than statins. We hypothesise that alirocumab treatment in addition to statin therapy could stabilise intracranial plaque and reduce arterial stenosis.
Methods and analysis
In this prospective, randomised, open-label, blinded end-point study, we will use h...
Source: BMJ Open - April 29, 2022 Category: General Medicine Authors: Huang, Y.-C., Chang, C.-H., Tsai, Y.-H., Weng, H.-H., Lin, L.-C., Lee, J.-D. Tags: Open access, Neurology Source Type: research
