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Source: BMJ Open

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Total 555 results found since Jan 2013.

Effects of whole-body vibration training on lower limb motor function and neural plasticity in patients with stroke: protocol for a randomised controlled clinical trial
This study has been approved by the Shanghai University of Sport Research Ethics Committee (102772021RT067) and will provide data on the effects of WBVT relative to RRT in terms of the improvement of stroke patients’ lower limb motor function and neural plasticity. The results of this study will be disseminated via publications in peer-reviewed journals and presentations at international conference. Trial registration number ChiCTR2200055143.
Source: BMJ Open - June 28, 2022 Category: General Medicine Authors: Zhang, M., Wei, J., Wu, X. Tags: Open access, Sports and exercise medicine Source Type: research

Thrombolysis, time-to-treatment and in-hospital outcomes among young adults with ischaemic stroke in China: findings from a nationwide registry study in China
Conclusion Young adults with AIS were more likely to receive IV tPA than older adults, although there was no difference between the two groups in time to treatment. Compared with older adults, young adults may had better in-hospital outcomes.
Source: BMJ Open - June 24, 2022 Category: General Medicine Authors: Wang, H.-Y., Gu, H.-Q., Zhou, Q., Jiang, Y.-Y., Yang, X., Wang, C.-J., Zhao, X.-Q., Wang, Y.-L., Liu, L.-P., Meng, X., Li, H., Liu, C., Li, Z.-X., Wang, Y.-J., Jiang, Y. Tags: Open access, Neurology Source Type: research

Study protocol of a non-randomised controlled trial evaluating the effectiveness of the F@ce 2.0 programme: a person-centred, ICT-supported and interdisciplinary rehabilitation intervention after stroke
Introduction Knowledge is missing on use of information and communication technology (ICT), for example, mobile phones/tablets in rehabilitation after stroke. F@ce 2.0 is a person-centred, interdisciplinary intervention supported by ICT. The components of F@ce 2.0 intend to increase performance in daily activities and participation in everyday life for patients with stroke and their significant others. Based on previous feasibility studies, a full-scale evaluation is planned in Sweden. The aim is to implement and evaluate F@ce 2.0, regarding performance of daily activities and participation in everyday life, in comparison ...
Source: BMJ Open - August 4, 2022 Category: General Medicine Authors: Eriksson, G., Tistad, M., Elf, M., Fors, U., von Koch, L., Ytterberg, C., Guidetti, S. Tags: Open access, Rehabilitation medicine Source Type: research

Community-based interventions to prevent stroke in low-income and middle-income countries: a protocol for a systematic review and meta-analysis
Introduction Stroke is the second leading cause of death and morbidity across the globe. In low-income and middle-income countries (LMICs), it has become an overwhelming burden over the past few decades. This burden is escalating at a much greater pace compared with that of high-income countries. It is considered the most frequent cause of adult disability that affects the quality of life. ‘Prevention’ is one of the key components to combating stroke. In this regard, community-based interventions can play a vital role in improving population-level health and well-being. Considering the escalating trend of strok...
Source: BMJ Open - August 8, 2022 Category: General Medicine Authors: Nowrin, I., Bhattacharyya, D. S., Saif-Ur-Rahman, K. M. Tags: Open access, Epidemiology Source Type: research

Efficacy and safety of human-derived neural stem cell in patients with ischaemic stroke: study protocol for a randomised controlled trial
Introduction Stroke is the most common cause of neurological disability in adults worldwide. Neural stem cell (NSC) transplantation has shown promising results as a treatment for stroke in animal experiments. The pilot investigation of stem cells in stroke phase 1 and phase 2 trials showed that transplantation of the highest dose (20 million cells) was well tolerated. Preliminary clinical benefits have also been observed. However, the trials were open-label and had a small sample size. Furthermore, human NSCs (hNSCs) were intracerebrally implanted, and some serious adverse events were considered to be related to the surgic...
Source: BMJ Open - November 8, 2022 Category: General Medicine Authors: Xie, C., Wang, K., Peng, J., Jiang, X., Pan, S., Wang, L., Wu, Y., Guan, Y. Tags: Open access, Neurology Source Type: research

Work situation of patients with stroke who have returned to work: a scoping review protocol
This study will be based on the Joanna Briggs Institute Reviewers’ Manual for scoping reviews. A systematic literature search will be conducted using related medical subject headings and keywords on the work situation of patients with stroke who have returned to work. Relevant publications will be searched using 17 data sources, including grey literature sources, published in English or Chinese between 1957 and 2022. None of the articles will have restrictions on the data sources or study designs. The study selection and search results will be reported and presented according to the Preferred Reporting Items for Syst...
Source: BMJ Open - December 14, 2022 Category: General Medicine Authors: Wang, H., Si, Y., Wu, G., Wen, J., Yang, M. Tags: Open access, Rehabilitation medicine Source Type: research

Development and internal validation of a clinical risk score for in-hospital mortality after stroke: a single-centre retrospective cohort study in Northwest Ethiopia
Conclusions The prediction model was developed from eight easy-to-collect predictors. The model has excellent discrimination and calibration performance, similar to that of the risk score model. It is simple, easily remembered, and helps clinicians identify the risk of patients and manage it properly. Prospective studies in different healthcare settings are required to externally validate our risk score.
Source: BMJ Open - March 28, 2023 Category: General Medicine Authors: Abebe, T. G., Feleke, S. F., Dessie, A. M., Anteneh, R. M., Anteneh, Z. A. Tags: Open access, Cardiovascular medicine Source Type: research

Improving sleep and learning in rehabilitation after stroke, part 2 (INSPIRES2): study protocol for a home-based randomised control trial of digital cognitive behavioural therapy (dCBT) for insomnia
Introduction Consolidation of motor skill learning, a key component of rehabilitation post-stroke, is known to be sleep dependent. However, disrupted sleep is highly prevalent after stroke and is often associated with poor motor recovery and quality of life. Previous research has shown that digital cognitive behavioural therapy (dCBT) for insomnia can be effective at improving sleep quality after stroke. Therefore, the aim of this trial is to evaluate the potential for sleep improvement using a dCBT programme, to improve rehabilitation outcomes after stroke. Methods and analysis We will conduct a parallel-arm randomised c...
Source: BMJ Open - April 6, 2023 Category: General Medicine Authors: Weightman, M., Robinson, B., Fallows, R., Henry, A. L., Kyle, S. D., Garratt, E., Pick, A., Teal, R., Ajina, S., Demeyere, N., Espie, C. A., Seymour, B., Johansen-Berg, H., Fleming, M. K. Tags: Open access, Rehabilitation medicine Source Type: research

Early identification and characterisation of stroke to support prehospital decision-making using artificial intelligence: a scoping review protocol
Introduction Stroke is a time-critical condition and one of the leading causes of mortality and disability worldwide. To decrease mortality and improve patient outcome by improving access to optimal treatment, there is an emerging need to improve the accuracy of the methods used to identify and characterise stroke in prehospital settings and emergency departments (EDs). This might be accomplished by developing computerised decision support systems (CDSSs) that are based on artificial intelligence (AI) and potential new data sources such as vital signs, biomarkers and image and video analysis. This scoping review aims to su...
Source: BMJ Open - May 22, 2023 Category: General Medicine Authors: Jalo, H., Seth, M., Pikkarainen, M., Häggström, I., Jood, K., Bakidou, A., Sjöqvist, B. A., Candefjord, S. Tags: Open access, Neurology Source Type: research

Barriers and facilitators in providing home-based rehabilitation for stroke survivors with severe disability in the UK: an online focus group study with multidisciplinary rehabilitation teams
Conclusions Collaboration and partnership working is important in the delivery of rehabilitation for stroke survivors with severe disability. Commissioners need to be aware that cross-agency multidisciplinary expertise is required, if rehabilitation opportunities are to be realised and existing health inequalities addressed.
Source: BMJ Open - August 2, 2023 Category: General Medicine Authors: Fisher, R. J., Russell, L., Riley-Bennett, F., Cameron, T., Walker, M., Sackley, C. Tags: Open access, Rehabilitation medicine Source Type: research

Effect of exoskeleton robot-assisted training on gait function in chronic stroke survivors: a systematic review of randomised controlled trials
Conclusion ERAT could be an efficient intervention to improve gait function for individuals who had a chronic stroke. However, more rigorously designed trials are required to draw more solid evidence. PROSPERO registration number CRD42023410796.
Source: BMJ Open - September 14, 2023 Category: General Medicine Authors: Yang, J., Gong, Y., Yu, L., Peng, L., Cui, Y., Huang, H. Tags: Open access, Rehabilitation medicine Source Type: research

Understanding clinicians' decisions to offer intravenous thrombolytic treatment to patients with acute ischaemic stroke: a protocol for a discrete choice experiment
Background Intravenous thrombolysis is an effective emergency treatment for acute ischaemic stroke for patients meeting specific criteria. Approximately 12% of eligible patients in England, Wales and Northern Ireland received thrombolysis in the first quarter of 2013, yet as many as 15% are eligible to receive treatment. Suboptimal use of thrombolysis may have been largely attributable to structural factors; however, with the widespread implementation of 24/7 hyper acute stroke services, continuing variation is likely to reflect differences in clinical decision-making, in particular the influence of ambiguous areas within ...
Source: BMJ Open - July 9, 2014 Category: Journals (General) Authors: De Brun,, A., Flynn, D., Joyce, K., Ternent, L., Price, C., Rodgers, H., Ford, G. A., Lancsar, E., Rudd, M., Thomson, R. G. Tags: Open access, Health services research Protocol Source Type: research

Integrative medicine for subacute stroke rehabilitation: a study protocol for a multicentre, randomised, controlled trial
Introduction Many patients with stroke receive integrative medicine in China, which includes the basic treatment of Western medicine and routine rehabilitation, in conjunction with acupuncture and Chinese medicine. The question of whether integrative medicine is efficacious for stroke rehabilitation is still controversial and very little research currently exists on the integrated approach for this condition. Consequently, we will conduct a multicentre, randomised, controlled, assessor-blinded clinical trial to assess the effectiveness of integrative medicine on stroke rehabilitation. Methods and analysis 360 participants...
Source: BMJ Open - December 4, 2014 Category: Journals (General) Authors: Fang, J., Chen, L., Chen, L., Wang, C., Keeler, C. L., Ma, R., Xu, S., Shen, L., Bao, Y., Ji, C. Tags: Open access, Complementary medicine Protocol Source Type: research

A randomised controlled trial of aerobic exercise after transient ischaemic attack or minor stroke to prevent cognitive decline: the MoveIT study protocol
In this study, we aim to investigate whether a physical exercise programme (MoveIT) can prevent cognitive decline in patients in the acute phase after a TIA or minor ischaemic stroke. Methods and analysis A single-blinded randomised controlled trial will be conducted to investigate the effect of an aerobic exercise programme on cognition compared with usual care. 120 adult patients with a TIA or minor ischaemic stroke less than 1 month ago will be randomly allocated to an exercise programme consisting of a 12-week aerobic exercise programme and regular follow-up visits to a specialised physiotherapist during the peri...
Source: BMJ Open - December 31, 2014 Category: Journals (General) Authors: Boss, H. M., Van Schaik, S. M., Deijle, I. A., de Melker, E. C., van den Berg, B. T. J., Scherder, E. J. A., Bosboom, W. M. J., Weinstein, H. C., Van den Berg-Vos, R. M. Tags: Open access, Neurology, Sports and exercise medicine Protocol Source Type: research

The burden of stroke in the Netherlands: estimating quality of life and costs for 1 year poststroke
Conclusions We found lower patient costs and higher QoL than expected. This may be explained by the good state of health of our study population and by change in the Dutch healthcare system, which has led to considerable shorter hospitalisation poststroke. Future research must question the use of the EQ-5D-3L in a similar population due to ceiling effects. Trial registration number NTR3051.
Source: BMJ Open - November 27, 2015 Category: Journals (General) Authors: van Eeden, M., van Heugten, C., van Mastrigt, G. A. P. G., van Mierlo, M., Visser-Meily, J. M. A., Evers, S. M. A. A. Tags: Open access, Health economics Research Source Type: research