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Executive function, but not memory, associates with incident coronary heart disease and stroke
Conclusion: Lower executive function, but not memory, is associated with higher risk of coronary heart disease and stroke. Lower executive function, as an independent risk indicator, might better reflect brain vascular pathologies.
Source: Neurology - August 31, 2015 Category: Neurology Authors: Rostamian, S., van Buchem, M. A., Westendorp, R. G. J., Jukema, J. W., Mooijaart, S. P., Sabayan, B., de Craen, A. J. M. Tags: All Cerebrovascular disease/Stroke, Cardiac, Cognitive aging, Cohort studies, Risk factors in epidemiology ARTICLE Source Type: research

Development and Feasibility of a Canine Endovascular Reversible Middle Cerebral Artery Occlusion Stroke Model: a Novel anterior circulation approach (P1.267)
Conclusions:Here we report the successful development of an endovascular reversible MCAo model in the canine by an anterior circulation approach. A learning curve is seen in the successful implementation of this model, as shown by our results.Disclosure: Dr. Guada has nothing to disclose. Dr. Ramdas has nothing to disclose. Dr. Atchaneeyasakul has nothing to disclose. Dr. Watanabe has nothing to disclose. Dr. Sidani has nothing to disclose. Dr. Yavagal has received personal compensation for activities with Medtronic and Guidepoint as a consultant.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Guada, L., Ramdas, K., Atchaneeyasakul, K., Watanabe, M., Sidani, C., Yavagal, D. Tags: Genetic Stroke Syndromes, Biomarkers, and Translational/Basic Research Source Type: research

National Stroke Registries: What can we learn from them?
Stroke is a major cause of long-term adult disability, death, and health care costs worldwide. This overwhelming burden on global health necessitates ongoing improvements in stroke management. Indeed, considerable progress in stroke care is evident nowadays, in part owing to better prevention and the increasing use of acute stroke units, urgent triage, multimodal CT- or MRI-based brain imaging, and IV and endovascular reperfusion therapy.
Source: Neurology - September 30, 2013 Category: Neurology Authors: Tanne, D., Koton, S., Bornstein, N. M. Tags: All Health Services Research, Outcome research, All Cerebrovascular disease/Stroke, All epidemiology GLOBAL PERSPECTIVES Source Type: research

Cognition and major depression after frontal and cerebellar stroke (P7.133)
CONCLUSIONS: Results in individuals with frontal lobe CVA were consistent with previous studies showing associations between cognition and depression in other neurologic disease. Disconnection and disruption in brain regions involving both emotion regulation and cognition may explain these associations. Alternatively, or simultaneously, depression may transiently impair cognitive test performance after frontal lobe stroke. Study Supported by:Disclosure: Dr. Dulay has nothing to disclose. Dr. Agbayani has nothing to disclose. Dr. Gadhia has nothing to disclose. Dr. Lai has nothing to disclose. Dr. Volpi has nothing to discl...
Source: Neurology - April 8, 2015 Category: Neurology Authors: Dulay, M., Agbayani, K., Gadhia, R., Lai, J., Volpi, J., Chiu, D., Zhang, Y. J., Britz, G. Tags: Cerebrovascular Disease and Interventional Neurology: Stroke, Depression, and Anxiety Source Type: research

Brain stimulation and constraint for perinatal stroke hemiparesis: The PLASTIC CHAMPS Trial
Conclusions: Hemiparetic children participating in intensive, psychosocial rehabilitation programs can achieve sustained functional gains. Addition of CIMT and rTMS increases the chances of improvement. Classification of evidence: This study provides Class II evidence that combined rTMS and CIMT enhance therapy-induced functional motor gains in children with stroke-induced hemiparetic cerebral palsy.
Source: Neurology - May 1, 2016 Category: Neurology Authors: Kirton, A., Andersen, J., Herrero, M., Nettel-Aguirre, A., Carsolio, L., Damji, O., Keess, J., Mineyko, A., Hodge, J., Hill, M. D. Tags: All Rehabilitation, Plasticity, TMS, Pediatric stroke; see Cerebrovascular Disease/ Childhood stroke ARTICLE Source Type: research

A Smartphone Application To Aid In The Evaluation, Treatment, And Clinical Trial Enrollment Of The Acute Stroke Patient (P7.125)
CONCLUSION: A smartphone application that centralizes various disparate resources may allow for more efficient management of the acute stroke patient. Further, such an application may allow easy screening for clinical trials by new practitioners as they learn of the various inclusion criteria for their studies.Disclosure: Dr. Nguyen has received royalty, or license fee, or contractual rights payments from the University of Texas. Dr. Wu has nothing to disclose. Dr. Barreto has nothing to disclose. Dr. Grotta has received personal compensation for activities with Lundbeck as a consultant. Dr. Savitz has received personal co...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Nguyen, C., Wu, T.-C., Barreto, A., Grotta, J., Savitz, S. Tags: Cerebrovascular Disease and Interventional Neurology: Issues in Acute Stroke Treatment Source Type: research

Transcranial direct current stimulation for children with perinatal stroke and hemiparesis
Conclusion: tDCS trials appear feasible and safe in hemiparetic children. Lack of change in objective motor function may reflect underdosing of therapy. Marked gains in subjective function with tDCS warrant further study. ClinicalTrials.gov identifier: NCT02170285. Classification of evidence: This study provides Class II evidence that for children with perinatal stroke and hemiparetic cerebral palsy, the addition of tDCS to moderate-dose motor learning therapy does not significantly improve motor function as measured by the AHA.
Source: Neurology - January 15, 2017 Category: Neurology Authors: Kirton, A., Ciechanski, P., Zewdie, E., Andersen, J., Nettel-Aguirre, A., Carlson, H., Carsolio, L., Herrero, M., Quigley, J., Mineyko, A., Hodge, J., Hill, M. Tags: Childhood stroke, Clinical trials Randomized controlled (CONSORT agreement), All Rehabilitation, Plasticity, TMS ARTICLE Source Type: research

The association of sleep apnea and stroke with cognitive performance: the REasons for Geographic And Racial Differences in Stroke (REGARDS) Study (I9-4B)
CONCLUSIONS These results suggest that S+SA is associated with lower verbal memory and executive function scores (but not highest global cognitive impairment) than SA only, stroke only, or neither.Disclosure: Dr. Molano has nothing to disclose. Dr. Kleindorfer has received personal compensation for activities with Genentech. Dr. McClure has received research support from Genzyme and Amgen. Dr. Unverzagt has received personal compensation for activities with Eli Lilly & Company as a consultant. Dr. Wadley has received personal compensation for activities with Amgen Inc. Dr. Howard has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Molano, J., Kleindorfer, D., McClure, L., Unverzagt, F., Wadley, V., Howard, V. Tags: Treating Dementia in an Age of Mixed Disease Data Blitz Presentations Source Type: research

The association of sleep apnea and stroke with cognitive performance: the REasons for Geographic And Racial Differences in Stroke (REGARDS) Study (S53.005)
CONCLUSIONS These results suggest that S+SA is associated with lower verbal memory and executive function scores (but not highest global cognitive impairment) than SA only, stroke only, or neither.Disclosure: Dr. Molano has nothing to disclose. Dr. Kleindorfer has received personal compensation for activities with Genentech. Dr. McClure has received research support from Genzyme and Amgen. Dr. Unverzagt has received personal compensation for activities with Eli Lilly & Company as a consultant. Dr. Wadley has received personal compensation for activities with Amgen Inc. Dr. Howard has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Molano, J., Kleindorfer, D., McClure, L., Unverzagt, F., Wadley, V., Howard, V. Tags: Sleep Source Type: research

Knowledge Translation in Right Brain Rehabilitation: A Feasibility Study of Prism Treatment After Acute Stroke (P6.210)
Conclusions:Fewer patients had spatial neglect than expected, but we demonstrated feasible knowledge translation for spatial neglect care in an underserved setting. An active-learning approach may be key to clinician engagement. Future research in stroke centers will help clarify the impact of neglect assessment and treatment on quality outcomes.Disclosure: Dr. Barrett has received personal compensation for activities with Kessler Foundation as an employee. Dr. Barrett has received research support from SPR therapeutics. Dr. Chen has nothing to disclose. Dr. Hreha has received personal compensation for activities with Kess...
Source: Neurology - April 3, 2016 Category: Neurology Authors: Barrett, A., Chen, P., Hreha, K., Alban, F., Gocon, C., Santos, C., Lawless, K., LaRosa, J. Tags: Behavioral and Cognitive Neurology: Brain-behavior Correlations Source Type: research

Is YouTube and Stroke a Bad Liaison? (P5.141)
CONCLUSIONS: YouTube provides a good and reliable source to learn the signs and symptoms of stroke but it features insufficient information about the use of IV-rtPA, risk factors, and prevention. Study Supported by: NONEDisclosure: Dr. Gupta has nothing to disclose. Dr. Patel has nothing to disclose. Dr. Jacob has nothing to disclose. Dr. Hinduja has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Gupta, H., Patel, R., Jacob, S., Hinduja, A. Tags: Cerebrovascular Disease and Interventional Neurology: Clinical Research Tools, Methods, and Innovations Source Type: research

Spatial-Motor Flexibility (SMF) and Post-Stroke Cognitive Recovery (P6.014)
Conclusions:The ability to direct movement flexibly in the side of body-centered space near impaired limbs may be needed for optimal functional stroke recovery. The clicker test provides an easy way to assess this ability and its performance may also reflect functioning of executive-action systems. Further studies examining whether SMF deficits predict cognitive recovery in stroke survivors more generally are needed.Disclosure: Dr. Barrett has received personal compensation for activities with Kessler Foundation as an employee. Dr. Barrett has received research support from SPR therapeutics. Dr. Zhang has nothing to disclo...
Source: Neurology - April 3, 2016 Category: Neurology Authors: Barrett, A., Zhang, R., Frey, S., Oh-Park, M. Tags: Cerebrovascular Disease and Interventional Neurology ePoster Session Source Type: research

Kinematic and Kinetic Outcome of Robot Assisted Neurorehabilitation in Chronic Moderate-to-Severe Hemiparetic Stroke (P3.298)
Conclusions: RT+TTT was not significantly different from RT alone, suggesting that TTT did not interfere with motor learning conferred by RT. Study Supported by: American Academy of Neurology (AAN) and the VA Department of Research and Development VA Merit Award B6935RDisclosure: Dr. Iqbal has nothing to disclose. Dr. Conroy has nothing to disclose. Dr. Roy has nothing to disclose. Dr. Bever has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Iqbal, T., Conroy, S., Roy, A., Bever, C. Tags: Neurorehabilitation Source Type: research

DWI Negative Stroke: Learning Points For Imaging In Acute Stroke (P1.037)
CONCLUSIONS: Clinical exam bears more weight than imaging in suspected brainstem infarcts. With the increasing use of DWI as the imaging of choice in acute stroke, DWI negative stroke must be considered in patients who present with classic brain stem infarcts with negative imaging to prevent delay in therapy as these patients may still be a candidate for thrombolysis.Disclosure: Dr. Nalleballe has nothing to disclose. Dr. JADEJA has nothing to disclose. Dr. Bollu has nothing to disclose. Dr. Onteddu has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Nalleballe, K., Jadeja, N., Bollu, P., Onteddu, S. Tags: Cerebrovascular Disease and Interventional Neurology: Case Reports Source Type: research

An Unusual Cause Of Recurrent Ischemic Stroke: Trousseau's Syndrome From Gastric Cancer (P4.231)
CONCLUSIONS: Trousseau’s Syndrome must be considered in those presenting with recurrent strokes with an otherwise negative embolic work up especially in the elderly and those with cancer risk factors. It must prompt the clinician to look for an associated malignancy.Disclosure: Dr. JADEJA has nothing to disclose. Dr. Johnson has nothing to disclose. Dr. Soetanto has nothing to disclose. Dr. Nalleballe has nothing to disclose. Dr. DeNiro has nothing to disclose. Dr. Qureshi has nothing to disclose. Dr. Graber has received personal compensation for activities with Stemedica Inc., Novocure Inc., and Biogen Idec.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Jadeja, N., Johnson, J., Soetanto, A., Nalleballe, K., DeNiro, L., Qureshi, I., Graber, J. Tags: Neuro-oncology: Paraneoplastic Disorders Source Type: research

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