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Drug: Zivast
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Glun2b N‐methyl‐D‐aspartic acid receptor subunit mediates atorvastatin‐Induced neuroprotection after focal cerebral ischemia
This study evaluates whether atorvastatin (ATV) treatment affects the GluN1 and GluN2B subunits of the N‐methyl‐D‐aspartic acid receptor in the somatosensory cerebral cortex at short and long periods following ischemia. Sham and ischemic male Wistar rats received 10 mg/kg of ATV or placebo by gavage every 24 hr for 3 consecutive days. The first dose was administered 6 hr after ischemia–reperfusion or the sham operation. ATV treatment resulted in faster recovery of neurological scores than placebo, prevented the appearance of pyknotic neurons, and restored microtubule‐associated protein 2 and neuronal nuclei stain...
Source: Journal of Neuroscience Research - June 17, 2014 Category: Neuroscience Authors: Johanna Andrea Gutierrez‐Vargas, Juan Ignacio Muñoz‐Manco, Luis Miguel Garcia‐Segura, Gloria Patricia Cardona‐Gómez Tags: Research Article Source Type: research
