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Source: Frontiers in Genetics
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Total 73 results found since Jan 2013.
Investigating the association of atopic dermatitis with ischemic stroke and coronary heart disease: A mendelian randomization study
Conclusion: Our MR study does not support a causal association of genetically predicted AD with ischemic stroke, large artery stroke, cardioembolic stroke, small vessel stroke, coronary heart disease, and myocardial infarction.
Source: Frontiers in Genetics - August 30, 2022 Category: Genetics & Stem Cells Source Type: research
Childhood Obesity and Risk of Stroke: A Mendelian Randomisation Analysis
Conclusion: Our study provides evidence that childhood obesity is associated with a higher risk of stroke, IS, and LAS. The prevention of stroke, especially IS and LAS, should be promoted in populations with childhood obesity.
Source: Frontiers in Genetics - November 17, 2021 Category: Genetics & Stem Cells Source Type: research
Genetic Contributors of Incident Stroke in 10,700 African Americans With Hypertension: A Meta-Analysis From the Genetics of Hypertension Associated Treatments and Reasons for Geographic and Racial Differences in Stroke Studies
Conclusion: This study highlights biologically plausible genetic determinants for incident stroke in hypertensive AAs. Ultimately, a better understanding of genetic risk factors for stroke in AAs may give new insight into stroke burden and potential clinical tools for those among the highest at risk.
Source: Frontiers in Genetics - December 21, 2021 Category: Genetics & Stem Cells Source Type: research
Stroke and Alzheimer ’s Disease: A Mendelian Randomization Study
In conclusion, different types of stroke, including AS, AIS, LAS, and CES, would not be causally associated with AD risk.
Source: Frontiers in Genetics - July 13, 2020 Category: Genetics & Stem Cells Source Type: research
Transcriptome Sequencing Unravels Potential Biomarkers at Different Stages of Cerebral Ischemic Stroke
This study assessed the characteristics of transcriptome changes at different stages of ischemic stroke using a mouse model of transient middle cerebral artery occlusion (tMCAO) and bioinformatics analyses. Cerebral cortex tissues from tMCAO mice at days 1, 3, 7, 14, and 28 were removed for RNA-Seq and small RNA-Seq library construction, sequencing, and bioinformatics analysis. We identified differentially expressed (DE) genes and miRNAs and revealed an association of the up-regulated or down-regulated DEmiRNAs with the correspondingly altered DEgene targets at each time point. In addition, different biological pathways we...
Source: Frontiers in Genetics - September 23, 2019 Category: Genetics & Stem Cells Source Type: research
Association of DNA Methylation Patterns in 7 Novel Genes With Ischemic Stroke in the Northern Chinese Population
Conclusion: Our results demonstrate that DNA methylation plays a crucial part in ischemic stroke. The methylation of these 7 genes may be potential diagnostic biomarker for ischemic stroke.
Source: Frontiers in Genetics - April 11, 2022 Category: Genetics & Stem Cells Source Type: research
Genetic Predisposition to Severe COVID-19 Might Increase the Risk of Stroke: A Two-Sample Mendelian Randomization Study
Conclusion: In summary, this study showed that severe COVID-19 might increase the risk of stroke, thus much more attention should be paid to patients with severe COVID-19.
Source: Frontiers in Genetics - August 12, 2022 Category: Genetics & Stem Cells Source Type: research
Exploring the bi-directional relationship and shared genes between depression and stroke via NHANES and bioinformatic analysis
Conclusion: We successfully identified the ten hub shared genes linking the IS and MDD and constructed the regulatory networks for them that could serve as novel targeted therapy for the comorbidities.
Source: Frontiers in Genetics - March 31, 2023 Category: Genetics & Stem Cells Source Type: research
Identification of the lncRNA –miRNA‒mRNA regulatory network for middle cerebral artery occlusion-induced ischemic stroke
Stroke known as a neurological disease has significant rates of disability and mortality. Middle cerebral artery occlusion (MCAO) models in rodents is crucial in stroke research to mimic human stroke. Building the mRNA and non-conding RNA network is essential for preventing MCAO-induced ischemic stroke occurrence. Herein, genome-wide mRNA, miRNA, and lncRNA expression profiles among the MCAO group at 3 h, 6 h, and 12 h after surgery and controls using high-throughput RNA sequencing. We detected differentially expressed mRNAs (DE-mRNAs), miRNAs (DE-miRNAs), and lncRNAs (DE-lncRNAs) between the MCAO and control groups. In...
Source: Frontiers in Genetics - May 9, 2023 Category: Genetics & Stem Cells Source Type: research
Association of Fibroblast Growth Factor 23 With Ischemic Stroke and Its Subtypes: A Mendelian Randomization Study
In this study, we aimed to assess the association of FGF23 with ischemic stroke and its subtypes by applying a Mendelian randomization (MR) framework. Five genetic variants obtained from a genome-wide association study involving 16,624 European subjects were used as valid instruments of circulating FGF23 levels. MR was applied to infer the causality of FGF23 levels and the risk of ischemic stroke using data from the MEGASTROKE consortium. Subsequently, several MR analyses, including inverse-variance weighted meta-analysis, MR-Egger, weighted median estimate (WME), MR Pleiotropy Residual Sum and Outlier were performed. The ...
Source: Frontiers in Genetics - December 23, 2020 Category: Genetics & Stem Cells Source Type: research
EDNRA Gene rs1878406 Polymorphism is Associated With Susceptibility to Large Artery Atherosclerotic Stroke
Conclusion: The rs1878406 C > T polymorphism is associated with increased risk of LAA stroke in the Chinese Han population.
Source: Frontiers in Genetics - January 3, 2022 Category: Genetics & Stem Cells Source Type: research
Circulating N-Terminal Probrain Natriuretic Peptide Levels in Relation to Ischemic Stroke and Its Subtypes: A Mendelian Randomization Study
Mendelian randomization was used to evaluate the potential causal association between N-terminal probrain natriuretic peptide (NT-proBNP) and ischemic stroke based on summary statistics data from large-scale genome-wide association studies. Three single-nucleotide polymorphisms (SNPs) rs198389, rs13107325, and rs11105306 associated with NT-proBNP levels found in large general populations and in patients with acute heart disease were used as instrumental variables. The results of genetic association analysis of each single SNP show that there is no significant association between NT-proBNP levels and ischemic stroke or its ...
Source: Frontiers in Genetics - February 22, 2022 Category: Genetics & Stem Cells Source Type: research
Evaluating the Causal Effects of TIMP-3 on Ischaemic Stroke and Intracerebral Haemorrhage: A Mendelian Randomization Study
Conclusion: Our results revealed that high levels of circulating TIMP-3 causally increased the risk of developing IS and SVS, but not CES, LAS, ICH, and all ICH subtypes. Further investigation is required to elucidate the underlying mechanism.
Source: Frontiers in Genetics - April 4, 2022 Category: Genetics & Stem Cells Source Type: research
Mendelian Randomization in Stroke: A Powerful Approach to Causal Inference and Drug Target Validation
Stroke is a leading cause of death and disability worldwide. However, our understanding of its underlying biology and the number of available treatment options remain limited. Mendelian randomization (MR) offers a powerful approach to identify novel biological pathways and therapeutic targets for this disease. Around ~100 MR studies have been conducted so far to explore, confirm, and quantify causal relationships between several exposures and risk of stroke. In this review, we summarize the current evidence arising from these studies, including those investigating ischemic stroke, hemorrhagic stroke, or both. We highlight ...
Source: Frontiers in Genetics - August 12, 2021 Category: Genetics & Stem Cells Source Type: research
Heart Failure and Ischemic Stroke: A Bidirectional and Multivariable Mendelian Randomization Study
Conclusion: This MR analysis provided evidence of the causal links between genetically predicted HF and IS. Subgroup analysis highlighted the causal or suggestive relationship between genetically predicted HF and LAS or CES. The potential causal links need further investigation with genetic information about other ancestries or etiologies of HF.
Source: Frontiers in Genetics - November 29, 2021 Category: Genetics & Stem Cells Source Type: research
