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Total 908 results found since Jan 2013.

Aggregation of human mesenchymal stem cells enhances survival and efficacy in stroke treatment
In this study, we report the effects of short-term preconditioning of hMSCs via three-dimensional (3D) aggregation on stroke lesion recovery after intra-arterial (IA) transplantation of 3D aggregate-derived hMSCs (Agg-D hMSCs) in a transient middle cerebral artery occlusion (MCAO) stroke model. Compared with two-dimensional (2D) monolayer culture, Agg-D hMSCs exhibited increased resistance to ischemic stress, secretory function and therapeutic outcome. Short-term preconditioning via 3D aggregation reconfigured hMSC energy metabolism and altered redox cycle, which activated the PI3K/AKT pathway and enhanced resistance to in...
Source: Cytotherapy - September 17, 2019 Category: Cytology Source Type: research

NODDI highlights recovery mechanisms in white and gray matter in ischemic stroke following human stem cell treatment
CONCLUSIONS: NODDI compliments DTI metrics, enhances interpretation of tissue outcome in ischemic stroke following hMSC application, and may be useful in evaluating or predicting therapeutic response.PMID:34355818 | DOI:10.1002/mrm.28929
Source: Magnetic Resonance in Medicine - August 6, 2021 Category: Radiology Authors: F Andrew Bagdasarian Xuegang Yuan Jacob Athey Bruce A Bunnell Samuel C Grant Source Type: research

O16/158 Artificial Intelligence based nationwide centralised decision supporting system for improving stroke case efficiency in Hungary
ConclusionUsing AI based centralized stroke imaging network fast and reliable decision support can be provided to a large nationwide stroke care system. The system was installed with the support of an EU grant EFOP 5.2.6.Disclosure of InterestIstvan Szikora has a consulting agreement with Brainomix Ltd.Zoltan Chadaide is a former employee of Brainomix Ltd.Edvard Benes is owner and CEO of eRAD-BBThe system was built by the support of an EU grant EFOP 5.2.6.The other authors have no relevant conflict of interest.
Source: Journal of NeuroInterventional Surgery - August 21, 2023 Category: Neurosurgery Authors: Szikora, I., Magyar, B., Papai, G., Szudi, G., Kondor, M., Czencz, M., Nardai, S., Chadaide, Z., Benes, E., Ovary, C., Eross, L. Tags: 2.2 ISCHEMIC - Imaging Source Type: research

Ultrafast in vivo diffusion imaging of stroke at 21.1 T by spatiotemporal encoding
ConclusionsConsideration of experiment duration, image quality, and mapped ADC values provided by spatiotemporally encoded demonstrates that this single‐shot acquisition is a method of choice for high‐throughput, ultrahigh‐field in vivo stroke quantification. Magn Reson Med, 2014. © 2014 Wiley Periodicals, Inc.
Source: Magnetic Resonance in Medicine - May 20, 2014 Category: Radiology Authors: Avigdor Leftin, Jens T. Rosenberg, Eddy Solomon, Fabian Calixto Bejarano, Samuel C. Grant, Lucio Frydman Tags: Full Paper Source Type: research

Wisconsin Coverdell Stroke Program receives $3.75 million to enhance statewide stroke care
The Department of Health Services will strengthen coordinated stroke care systems statewide thanks to a 5-year, $3.75 million CDC grant to continue the Wisconsin Coverdell Stroke Program , health officials announced today. Wisconsin is one of only nine states to receive the funding. “Continued support for our stroke care initiative will help us increase the likelihood that patients throughout the state receive fast and high quality stroke care,” said Dr...(see release)
Source: Wisconsin DHFS Press Releases - July 24, 2015 Category: Hospital Management Authors: yunkecfrrr Source Type: news

"The ipsilesional attention bias in right-hemisphere stroke patients as revealed by a realistic visual search task: Neuroanatomical correlates and functional relevance": Correction to Machner et al. (2018).
Conclusions: Results from the novel desk task indicate a functional relevance of spatial attention deficits in right-hemisphere stroke patients, even if they are “subclinical.” This should be considered especially in patients without obvious clinical neglect signs. (PsycINFO Database Record (c) 2019 APA, all rights reserved)
Source: Neuropsychology - April 29, 2019 Category: Neurology Source Type: research

O19 Late-window aspiration thrombectomy for anterior Acute Ischemic Stroke: subset analysis for COMPLETE Study
ConclusionsLate-window aspiration thrombectomy with Penumbra System is safe and effective for patients with anterior circulation stroke. Our study reports rates of good functional outcome that compare favorably to the DAWN and DEFUSE-3 medical management arms.ReferencesNogueira Rg et al. Dawn Trial Investigators. Thrombectomy 6 to 24 Hours after Stroke with a Mismatch between Deficit and Infarct. N Engl J Med. 2018 Jan 4;378(1):11–21. DOI: 10.1056/NEJMOA1706442. EPUB 2017 Nov 11. PMID: 29129157.Albers GW et al. Defuse 3 Investigators. Thrombectomy for Stroke at 6 To 16 Hours with Selection by Perfusion Imaging. N Eng...
Source: Journal of NeuroInterventional Surgery - August 29, 2022 Category: Neurosurgery Authors: Hassan, A., Fifi, J., Zaidat, O. Tags: 14th Congress of the European Society of Minimally Invasive Neurological Therapy 2022 Meeting Abstracts Source Type: research

Ischemic Stroke Related to Severe Iron-Deficiency Anemia in Adults May Benefit from Blood Transfusion (P01.232)
CONCLUSIONS: Prevalence of IDA is 1-20%; it is 3.9% in our AIS population and is often related to untreated uterine bleeding. As described in the pediatric population, severe IDA may be an underlying mechanism of ischemic stroke in adults, therefore, efforts must be undertaken to identify and treat the cause of the anemia. While patients with AIS and severe IDA may receive TPA, blood transfusion may be considered as an adjuvant therapy.Supported by: SPOTRIAS P50 NS044227 & NIH Training Grant 5T 32NS0077412-12.Disclosure: Dr. Choi has nothing to disclose. Dr. Sanchez-Rotunno has nothing to disclose. Dr. Gonzales has nothing to disclose.
Source: Neurology - February 14, 2013 Category: Neurology Authors: Choi, E., Sanchez-Rotunno, M., Gonzales, N. Tags: P01 Cerebrovascular Disease I Source Type: research

Editorial Disparities in stroke: not just black and white
At the start of American Stroke Month, on May 1, 2013, the National Institute for Neurological Disorders and Stroke (NINDS) announced grant awards aimed at reducing the risk and consequences of stroke among racial and ethnic minorities in the USA. The greater risks and poorer outcomes in these groups compared with white people have long been a concern for health-care providers and patients, and without action this gap is expected to widen. Targeting this problem is an important opportunity to reduce not only this disparity but also the overall burden of stroke in the USA.
Source: Lancet Neurology - June 16, 2013 Category: Neurology Authors: The Lancet Neurology Tags: Editorial Source Type: research

Testing the Presumption of Consent to Emergency Thrombolysis for Stroke (S35.005)
CONCLUSIONS: The proportion of older adults who would want emergency thrombolysis is comparable to the proportion who would want emergency CPR, and is unaffected by the inability to obtain informed consent.Study Supported by: National Institute on Aging (K23AG043553), National Center for Advancing Translational Sciences (KL2TR000143), and the American Brain Foundation Clinical Research Training Fellowship Program. Data collection was provided by Time-sharing Experiments in the Social Sciences, NSF Grant 0818839.Disclosure: Dr. Chiong has nothing to disclose. Dr. Kim has received research support from SanBio, Inc. Dr. Huang...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Chiong, W., Kim, A., Huang, I., Farahany, N., Josephson, S. Tags: Cerebrovascular Disease and Interventional Neurology: Issues in Acute Treatment Source Type: research

Altered resting-state network connectivity in stroke patients with and without apraxia of speech (S49.002)
CONCLUSIONS: These results highlight the left PM region’s involvement in AOS, begin to differentiate it’s neural mechanisms from those of other motor impairments following stroke, and help inform us of the neural mechanisms driving differences in speech motor planning and programming following stroke. Study Supported by: National Health and Medical Research Council Project Grant 632763Disclosure: Dr. New has nothing to disclose. Dr. Kirrie has nothing to disclose. Dr. Parkinson has nothing to disclose. Dr. Duffy has nothing to disclose. Dr. McNeil has nothing to disclose. Dr. Piguet has nothing to disclose. Dr....
Source: Neurology - April 8, 2015 Category: Neurology Authors: New, A., Kirrie, B., Parkinson, A., Duffy, J., McNeil, M., Piguet, O., Hornberger, M., Price, C., Eickhoff, S., Robin, D. Tags: Aging, Dementia, Cognitive, and Behavioral Neurology: Imaging: Behavioral Neurology and non-Alzheimer ' s Disease Dementias Source Type: research

Review finds no link between dairy and heart attack or stroke risk
Conclusion This large meta-analysis of cohort studies demonstrated no increased risk to cardiovascular disease, coronary heart disease or all-cause death from eating dairy products. The review has strengths in its large size and the fact it was able to analyse different types of dairy product, such as high and low-fat and everyday products such as cheese and yoghurt. However, there are a number of factors to consider: The results of a systematic review are only as good as the quality of the underlying studies. These are all observational studies and it's possible that unadjusted health and lifestyle factors are having an...
Source: NHS News Feed - May 9, 2017 Category: Consumer Health News Tags: Food/diet Heart/lungs Neurology Source Type: news