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Sphingosine-1-phosphate and Sphingosine-1-phosphate receptors in the cardiovascular system: pharmacology and clinical implications
Adv Pharmacol. 2022;94:95-139. doi: 10.1016/bs.apha.2022.02.001. Epub 2022 Mar 30.ABSTRACTSphingosine-1-phosphate (S1P) is a lipid that binds and activates five distinct receptor subtypes, S1P1, S1P2, S1P3, S1P4, S1P5, widely expressed in different cells, tissues and organs. In the cardiovascular system these receptors have been extensively studied, but no drug acting on them has been approved so far for treating cardiovascular diseases. In contrast, a number of S1P receptor agonists are approved as immunomodulators, mainly for multiple sclerosis, because of their action on lymphocyte trafficking. This chapter summarizes t...
Source: Advances in Pharmacology - June 6, 2022 Category: Drugs & Pharmacology Authors: Simona Federica Spampinato Maria Angela Sortino Salvatore Salomone Source Type: research
