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Ferroptosis and its potential as a therapeutic target
Biochem Pharmacol. 2021 Feb 22:114486. doi: 10.1016/j.bcp.2021.114486. Online ahead of print.ABSTRACTFerroptosis is a recently defined form of programmed cell death that is different from apoptosis. It is an iron-dependent programmed cell death and the accumulation of lipid hydroperoxides to lethal levels make ferroptosis distinct. Ferroptosis can be effectively regulated by a number of cellular variables including iron content, amino acid uptake, polyunsaturated fatty acid incorporation, glutathione biosynthesis, and NADPH levels. A number of severe and common degenerative diseases in humans such as Parkinson's disease an...
Source: Biochemical Pharmacology - February 25, 2021 Category: Drugs & Pharmacology Authors: Hanshu Yuan Justin Pratte Charles Giardina Source Type: research

Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease
Publication date: 5 October 2017 Source:Cell, Volume 171, Issue 2 Author(s): Brent R. Stockwell, José Pedro Friedmann Angeli, Hülya Bayir, Ashley I. Bush, Marcus Conrad, Scott J. Dixon, Simone Fulda, Sergio Gascón, Stavroula K. Hatzios, Valerian E. Kagan, Kay Noel, Xuejun Jiang, Andreas Linkermann, Maureen E. Murphy, Michael Overholtzer, Atsushi Oyagi, Gabriela C. Pagnussat, Jason Park, Qitao Ran, Craig S. Rosenfeld, Konstantin Salnikow, Daolin Tang, Frank M. Torti, Suzy V. Torti, Shinya Toyokuni, K.A. Woerpel, Donna D. Zhang Ferroptosis is a form of regulated cell death characterized by the iron-dependent accumulation...
Source: Cell - October 29, 2017 Category: Cytology Source Type: research