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Interleukin-33 Protects Ischemic Brain Injury by Regulating Specific Microglial Activities
Publication date: 10 August 2018 Source:Neuroscience, Volume 385 Author(s): Qianping Luo, Yong Fan, Lili Lin, Jingjing Wei, Zuanfang Li, Yongkun Li, Susumu Nakae, Wei Lin, Qi Chen Interleukin-33 (IL-33), a novel member of the IL-1 family, expressed in many tissue and cell types, is involved in inflammation and immune functions. Previous studies suggest that IL-33 may play a role in ischemic stroke. Here, we evaluated the effect of IL-33 in cerebral ischemia–reperfusion-induced injury and investigated its underlying mechanism. Our data indicated that IL-33 deficiency exacerbated the neurological dysfunction caused by cer...
Source: Neuroscience - June 22, 2018 Category: Neuroscience Source Type: research
