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Analysis of CYP2C19 genetic variants with ischaemic events in UK patients prescribed clopidogrel in primary care: a retrospective cohort study
Conclusions A substantial proportion of the UK population carry genetic variants that reduce metabolism of clopidogrel to its active form. In family practice patients on clopidogrel, CYP2C19 LoF variants are associated with substantially higher incidence of ischaemic events. Genotype-guided selection of antiplatelet medications may improve outcomes in patients carrying CYP2C19 genetic variants.
Source: BMJ Open - December 13, 2021 Category: General Medicine Authors: Pilling, L. C., Türkmen, D., Fullalove, H., Atkins, J. L., Delgado, J., Kuo, C.-L., Kuchel, G. A., Ferrucci, L., Bowden, J., Masoli, J. A. H., Melzer, D. Tags: Open access, Cardiovascular medicine Source Type: research

Dual antiplatelet Tx for stroke prevention: Worth the risk?
Abstract Here's what the evidence tells us about the use of 2 regimens-clopidogrel + aspirin and ER dipyridamole + aspirin-to prevent secondary ischemic stroke. PMID: 32724907 [PubMed - in process]
Source: The Journal of Family Practice - June 30, 2020 Category: Practice Management Authors: Helmer RS, Helmer AM, Smithgall S Tags: J Fam Pract Source Type: research