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Incidence of Stroke in the US Centers for AIDS Research (CFAR) Network of Integrated Clinical Systems (CNICS) Cohort (S51.008)
Conclusions:In this large study of neurologist adjudicated stroke in a HIV cohort, the AS stroke incidence rate was 337.7. The stroke rate was higher in women, African-Americans and older ages. These incidence data, combined with additional risk factor analyses, and comparisons with non-HIV cohorts, will allow better understanding of stroke in HIV, with the ultimate goal of improved outcomes.Study Supported by: NIAID, NHLBI (5R24AI067039) and AHA (13GRNT14560022)Disclosure: Dr. Tirschwell has received research support from St. Jude Medical and Bayer. Dr. Chow has nothing to disclose. Dr. Becker has received personal compen...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Tirschwell, D., Chow, F., Becker, K., Marra, C., Zunt, J., Ho, E., Kalani, R., Huffer, A., Nance, R., Williams-Nguyen, J., Burkholder, G., Moore, R., Mathews, W., Eron, J., Drozd, D., Kitahata, M., Saag, M., Crane, H. Tags: Cerebrovascular Disease and Interventional Neurology: Stroke Prevention and Translation Source Type: research

Developing a Family of Visual Decision Aids for Intravenous and Endovascular Reperfusion Therapies for Acute Ischemic Stroke (S25.006)
Conclusions:Personograph visual decision aids are a promising approach to rapidly educating patients, family, and healthcare providers on the benefits and risks of the major reperfusion therapies for acute ischemic stroke.Disclosure: Dr. Tokunboh has nothing to disclose. Dr. Vales Montero has nothing to disclose. Dr. Zopelaro has nothing to disclose. Dr. Sharma has nothing to disclose. Dr. Gonzalez has received research support from NIH. Dr. Starkman has received research support from the National Institute of Health, Stryker, Biogen IDEC, Neuravi, Genentech, Covidien, and Astra-Zeneca. Dr. Szeder has nothing to disclose. ...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Tokunboh, I., Montero, M. V., Zopelaro, M., Sharma, L., Gonzalez, N., Starkman, S., Szeder, V., Jahan, R., Liebeskind, D., Saver, J. Tags: Cerebrovascular Disease and Interventional Neurology: Prehospital and Emergency Department Ischemic Stroke Care Source Type: research

Post-Stroke Disability at a National Referral Hospital in Tanzania (P3.322)
Conclusions:In this low-resource setting, individuals with stroke face a severe burden of disability and high risk of mortality. The majority of participants experienced severe deficits following stroke, as assessed through NIHSS and mRS. While this study may be limited by referral bias, the high toll of disability among this population suggests that post-stroke disability places a significant burden on Tanzanian families and society.Study Supported by:This abstract was made possible with help from the Harvard University Center for AIDS Research (CFAR), an NIH funded program (P30 AI060354), subgrant to F. Mateen.Disclosure...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Wibecan, L., Mmbando, T., Grundy, S., Klein, J., Mateen, F., Okengo, K. Tags: Global Health Source Type: research

Cerebrovascular Disease and HIV in Singapore: A Single-Centre Study (P1.325)
Conclusions: Prevalence of CVS risk factors was significant in our population. Stroke in HIV patients may result from other disease mechanisms and carries significant mortality and morbidity. Fever at presentation suggests an infective etiology.Disclosure: Dr. Gan holds stock and/or stock options in a company which sponsored research in which Dr. Gan was involved as an investigator. Dr. Saini has nothing to disclose. Dr. Lee has nothing to disclose. Dr. Ng has nothing to disclose. Dr. Tan has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Gan, E., Saini, M., Lee, C.-C., Ng, O.-T., Tan, K. Tags: HIV/AIDS Source Type: research

The merging burden of HIV infection and stroke in the developing world
According to the WHO, at the end of 2014, the majority of the approximately 36.9 million people living with HIV/AIDS resided in low- to middle-income countries in sub-Saharan Africa.1 The same report indicated that cases in sub-Saharan Africa account for almost 70% of the global total of new HIV infections.1 The burden of stroke in developing countries parallels that of HIV/AIDS. Approximately 80% of people who have had a stroke live in low- to middle-income nations.2 Over the past 4 decades, stroke incidence in these countries has increased by more than 100%.3 In developing nations, HIV/AIDS and stroke are not mutually ex...
Source: Neurology - January 25, 2016 Category: Neurology Authors: Behrouz, R., Gottesman, R. F. Tags: Stroke in young adults, HIV, All Cerebrovascular disease/Stroke EDITORIALS Source Type: research

Stroke and the noncommunicable diseases: A global burden in need of global advocacy
Catalyzed by advocacy in the early period of the global AIDS crisis, the past decades have witnessed a revolution in global health funding, programs, and outcomes. In 2011, global HIV/AIDS programs received $7.7 billion of development assistance, amounting to 25% of total global health funding. In comparison, all noncommunicable diseases (NCDs) combined received only $377 million or 1.2% of global health funding, 20-fold less than HIV/AIDS funding.1 Taken together, NCDs cause an estimated 66% of yearly global mortality.2 The percentage of estimated total global mortality due to stroke (11.3%), a single NCD, exceeds that of...
Source: Neurology - May 25, 2015 Category: Neurology Authors: Berkowitz, A. L. Tags: Stroke prevention, All Cerebrovascular disease/Stroke GLOBAL PERSPECTIVES Source Type: research

The Changing Epidemiology of Stroke in Acquired Immune Deficiency Syndrome (AIDS). (I7-1A)
Conclusions:There is an increased frequency of AIDS among stroke patients, possibly due to the increased detection of AIDS. In the HAART era, the median age of incident stroke in AIDS has increased. Whether HAART can reduce the incidence and improve survival of stroke needs to be explored.Disclosure: Dr. Kucab has received personal compensation for activities with Bayer HealthCare as an advisory board participant. Dr. Bhattacharya has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Kucab, P., Bhattacharya, P. Tags: The Global Burden of Neurological Infections: Epidemiology, Treatment, and Prevention Data Blitz Presentations Source Type: research

The Changing Epidemiology of Stroke in Acquired Immune Deficiency Syndrome (AIDS). (P1.089)
Conclusions:There is an increased frequency of AIDS among stroke patients, possibly due to the increased detection of AIDS. In the HAART era, the median age of incident stroke in AIDS has increased. Whether HAART can reduce the incidence and improve survival of stroke needs to be explored.Disclosure: Dr. Kucab has received personal compensation for activities with Bayer HealthCare as an advisory board participant. Dr. Bhattacharya has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Kucab, P., Bhattacharya, P. Tags: Neuroepidemiology: Cerebrovascular Disease Source Type: research

The global burden of neurologic diseases
WHO categorizes causes of death and disability into (1) communicable diseases, maternal and perinatal conditions, and nutritional deficiencies; (2) non-communicable diseases (NCD); and (3) injuries. NCD are the leading cause of death and disability globally and are rising as a result of demographic and epidemiologic changes occurring in both developed and developing countries.1,2 Increasing life expectancies, unhealthy diet, physical inactivity, tobacco use, and harmful use of alcohol contribute to the growing incidence and prevalence of NCD, such as heart disease, stroke, diabetes, cancers, and chronic respiratory disease...
Source: Neurology - July 21, 2014 Category: Neurology Authors: Chin, J. H., Vora, N. Tags: All Cerebrovascular disease/Stroke, All epidemiology, All Epilepsy/Seizures GLOBAL PERSPECTIVES Source Type: research

Stroke in Children with Human Immunodeficiency Virus in Botswana: A Report of Six Cases (P4.303)
CONCLUSIONS: The risk of stroke appears to be increased in children with HIV, though further controlled studies are necessary to further investigate this. Etiologies for stroke in children with HIV includes HIV vasculopathy, HIV cardiomyopathy, and opportunistic infections. Evaluation should include head imaging with vascular imaging, MRI with MRA if possible, and CT. The utility of lumbar puncture and hypercoaguability workup in this population needs to be investigated further. Given the difficulties of monitoring anticoagulation in this setting, low dose aspirin is a reasonable first line treatment.Disclosure: Dr. Khuran...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Khurana, E., Bearden, D. Tags: NeuroAIDS Source Type: research

Unusual Presentation of Acute Carbon Monoxide Poisoning (P6.024)
CONCLUSIONCO poisoning should be included in the differential diagnosis of patients found to have isolated bilateral thalamic involvement. MR imaging undertaken in acute setting aids in management and prognosis. Follow-up is required to assess for the development of Delayed Neuropsychiatric Syndrome, which can cause changes in personality, memory and gait.Disclosure: Dr. Bains has nothing to disclose. Dr. Reid has nothing to disclose. Dr. Huang has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Bains, S., Reid, D., Huang, X. Tags: General Neurology VI Source Type: research

Intraoperative Neurophysiologic Monitoring of Surgical and Endovascular Treatment of Pediatric Arteriovenous Malformations (S55.002)
CONCLUSIONS:Persistent IONM changes had a strong correlation with new post-operative deficits. Transient IONM changes, including those resolving after alterations in surgical management or pre-embolization methohexital testing, had a much lower risk of new deficits. Therefore, IONM can be a useful tool in pediatric AVM cases, not only in predicting neurological compromise, but also in identifying when to alter management.Study Supported by:N/ADisclosure: Dr. Nguyen has nothing to disclose. Dr. Avila has nothing to disclose. Dr. Lee has nothing to disclose. Dr. Cho has nothing to disclose. Dr. Le has nothing to disclose. Dr...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Nguyen, V., Avila, S., Lee, L., Cho, S., Le, S., Lopez, J. Tags: Pediatric Stroke and Stroke in the Young Source Type: research

Long-term predictive value of the Framingham Risk Score for Stroke in HIV-positive vs HIV-negative men
Conclusions: FRS-S prediction was systematically different in HIV+ vs HIV– men with stroke events. The FRS-S underestimates the long-term risk of stroke in HIV+ men.
Source: Neurology - December 9, 2013 Category: Neurology Authors: Mateen, F. J., Post, W. S., Sacktor, N., Abraham, A. G., Becker, J. T., Smith, B. R., Detels, R., Martin, E., Phair, J. P., Shinohara, R. T., For the Multicenter AIDS Cohort Study (MACS) Investigators Tags: Viral infections, HIV, All Cerebrovascular disease/Stroke, Cohort studies, Risk factors in epidemiology ARTICLE Source Type: research