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Synaptic inputs from stroke-injured brain to grafted human stem cell-derived neurons activated by sensory stimuli
<span class="paragraphSection"><div class="boxTitle">Abstract</div>Transplanted neurons derived from stem cells have been proposed to improve function in animal models of human disease by various mechanisms such as neuronal replacement. However, whether the grafted neurons receive functional synaptic inputs from the recipient’s brain and integrate into host neural circuitry is unknown. Here we studied the synaptic inputs from the host brain to grafted cortical neurons derived from human induced pluripotent stem cells after transplantation into stroke-injured rat cerebral cortex. Using the rabies virus-b...
Source: Brain - January 21, 2017 Category: Neurology Source Type: research