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Clinical outcome of patients with mild pre-stroke morbidity following endovascular treatment: a HERMES substudy
Conclusions Patients asymptomatic/without disability prior to onset have better outcomes following EVT than patients with mild disability/symptoms. Patients with pre-stroke mRS 1–2, however, more often achieve good outcomes with EVT compared with conservative management. These findings indicate that mild pre-existing disability/symptoms influence patient prognosis after EVT but do not diminish the EVT treatment effect.
Source: Journal of NeuroInterventional Surgery - February 14, 2023 Category: Neurosurgery Authors: McDonough, R. V., Ospel, J. M., Majoie, C. B. L. M., Saver, J. L., White, P., Dippel, D. W. J., Brown, S. B., Demchuk, A. M., Jovin, T. G., Mitchell, P. J., Bracard, S., Campbell, B. C. V., Muir, K. W., Hill, M. D., Guillemin, F., Goyal, M., on behalf of Tags: Ischemic stroke Source Type: research

Benefit of successful reperfusion achieved by endovascular thrombectomy for patients with ischemic stroke and moderate pre-stroke disability (mRS 3): results from the MR CLEAN Registry
Conclusions Although patients with AIS with pre-stroke mRS 3 comprise a heterogenous group of disability causes, we observed improved outcomes when patients achieved successful reperfusion after EVT.
Source: Journal of NeuroInterventional Surgery - April 13, 2023 Category: Neurosurgery Authors: Benali, F., Kappelhof, M., Ospel, J., Ganesh, A., McDonough, R. V., Postma, A. A., Goldhoorn, R.-J. B., Majoie, C. B. L. M., van den Wijngaard, I., Lingsma, H. F., Vos, J. A., van Oostenbrugge, R. J., van Zwam, W. H., Goyal, M., on behalf of MR CLEAN Regi Tags: Ischemic stroke Source Type: research

Hyperglycemic control in acute ischemic stroke patients undergoing endovascular treatment: post hoc analysis of the Stroke Hyperglycemia Insulin Network Effort trial
Conclusion We did not identify any beneficial effect of intensive glucose reduction on rates of death or favorable outcomes at 90 days among acute ischemic stroke patients undergoing endovascular treatment.
Source: Journal of NeuroInterventional Surgery - March 14, 2023 Category: Neurosurgery Authors: Bains, N. K., Huang, W., French, B. R., Siddiq, F., Gomez, C. R., Qureshi, A. I. Tags: Ischemic stroke Source Type: research

M1 is not M1 in ischemic stroke: the disability-free survival after mechanical thrombectomy differs significantly between proximal and distal occlusions of the middle cerebral artery M1 segment
Conclusions Proximal occlusions of the M1 segment of the MCA incorporating the lenticulostriate perforators are associated with a poorer clinical outcome than distal M1 occlusions that spare these perforators. Involvement of these perforators might become an additional predictor of clinical outcome after mechanical thrombectomy in ischemic stroke.
Source: Journal of NeuroInterventional Surgery - July 14, 2015 Category: Neurosurgery Authors: Behme, D., Kowoll, A., Weber, W., Mpotsaris, A. Tags: Ischemic stroke Source Type: research

Patient-reported outcome measures after thrombectomy in patients with acute stroke: fine-tuning the modified Rankin Scale
Conclusions A specifically designed digital platform allows a high collection rate of PROMs among stroke patients who underwent EVT. The mRS score shows a ceiling effect and seems insufficient to fine-tune long-term clinical results. The use of PROMs may allow a better characterization of long-term outcome profiles after EVT.
Source: Journal of NeuroInterventional Surgery - June 16, 2023 Category: Neurosurgery Authors: Cano, D., Montiel, E., Baladas, M., Sanchez-Gavilan, E., Paredes, C., Rubiera, M., Requena, M., Muchada, M., Olive Gadea, M., Garcia-Tornel, A., Molina, C. A., Ribo, M. Tags: Ischemic stroke Source Type: research

Early arrival at the emergency department is associated with better collaterals, smaller established infarcts and better clinical outcomes with endovascular stroke therapy: SWIFT study
Conclusions Time was a critical factor in successful clinical outcomes for neurothrombectomy in the SWIFT trial. Shorter times to presentation were associated with better collaterals, smaller established infarcts, and better clinical outcome after revascularization.
Source: Journal of NeuroInterventional Surgery - May 12, 2016 Category: Neurosurgery Authors: Liebeskind, D. S., Jahan, R., Nogueira, R. G., Jovin, T. G., Lutsep, H. L., Saver, J. L., for the SWIFT Investigators Tags: Editor''s choice, Ischemic stroke Source Type: research

Quantified health and cost effects of faster endovascular treatment for large vessel ischemic stroke patients in the Netherlands
Conclusion One-minute faster EVT increases QALYs while cumulative costs remain largely unaffected. Therefore, faster EVT provides better value of care at no extra healthcare costs.
Source: Journal of NeuroInterventional Surgery - November 18, 2021 Category: Neurosurgery Authors: van Voorst, H., Kunz, W. G., van den Berg, L. A., Kappelhof, M., Pinckaers, F. M. E., Goyal, M., Hunink, M. G. M., Emmer, B. J., Mulder, M. J. H. L., Dippel, D. W. J., Coutinho, J. M., Marquering, H. A., Boogaarts, H. D., van der Lugt, A., van Zwam, W. H. Tags: Open access, Ischemic stroke Source Type: research

Toward a more inclusive paradigm: thrombectomy for stroke patients with pre-existing disabilities
Conclusions While baseline mRS was associated with absolute 90-day disability, there was no association with accumulated disability or other outcomes. Patients with baseline disability should not be routinely excluded from EVT based on baseline mRS alone.
Source: Journal of NeuroInterventional Surgery - September 15, 2021 Category: Neurosurgery Authors: Regenhardt, R. W., Young, M. J., Etherton, M. R., Das, A. S., Stapleton, C. J., Patel, A. B., Lev, M. H., Hirsch, J. A., Rost, N. S., Leslie-Mazwi, T. M. Tags: Editor''s choice, Ischemic stroke Source Type: research

Endovascular reperfusion of M2 occlusions in acute ischemic stroke reduced disability and mortality: ETIS Registry results
Conclusions Successful reperfusion of M2 occlusions reduced disability and mortality. However, safety is a concern, especially if the procedure failed.
Source: Journal of NeuroInterventional Surgery - April 12, 2022 Category: Neurosurgery Authors: Muszynski, P., Anadani, M., Richard, S., Marnat, G., Bourcier, R., Sibon, I., Dargazanli, C., Arquizan, C., Maïer, B., Blanc, R., Lapergue, B., Consoli, A., Eugene, F., Vannier, S., Spelle, L., Denier, C., Boulanger, M., Gauberti, M., Saleme, S., Tags: Ischemic stroke Source Type: research

Improved clinical outcome 3 months after endovascular treatment, including thrombectomy, in patients with acute ischemic stroke: a meta-analysis
Conclusions Endovascular treatment in addition to intravenous thrombolysis for acute ischemic stroke leads to an improved clinical outcome after 3 months, compared with patients receiving intravenous thrombolysis alone.
Source: Journal of NeuroInterventional Surgery - June 13, 2016 Category: Neurosurgery Authors: Falk-Delgado, A., Kuntze Söderqvist, A., Fransen, J., Falk-Delgado, A. Tags: Open access, Ischemic stroke Source Type: research

Stroke prevention by endovascular treatment of carotid and vertebral artery dissections
Conclusions Patients with CAD and VAD differ significantly in presentation, indications for treatment, and treatment methods. Endovascular treatment of CAD and VAD has low procedural morbidity and is associated with a low incidence of future stroke.
Source: Journal of NeuroInterventional Surgery - September 12, 2017 Category: Neurosurgery Authors: Moon, K., Albuquerque, F. C., Cole, T., Gross, B. A., McDougall, C. G. Tags: Ischemic stroke Source Type: research

Effects of endovascular therapy for mild stroke due to proximal or M2 occlusions: meta-analysis
Conclusions For patients with mild AIS, observational data suggest that EVT may be beneficial for proximal ICA or M1 but not for distal M2 occlusions. Randomized trials are needed to confirm these findings. PROSPERO registration number CRD42021281034.
Source: Journal of NeuroInterventional Surgery - March 14, 2023 Category: Neurosurgery Authors: Lin, C.-H., Saver, J. L., Ovbiagele, B., Tang, S.-C., Lee, M., Liebeskind, D. S. Tags: Open access, Ischemic stroke Source Type: research

M2 occlusions as targets for endovascular therapy: comprehensive analysis of diffusion/perfusion MRI, angiography, and clinical outcomes
Conclusions If suitable as targets of ET, M2 occlusions should be given the same consideration as M1 occlusions.
Source: Journal of NeuroInterventional Surgery - June 11, 2015 Category: Neurosurgery Authors: Sheth, S. A., Yoo, B., Saver, J. L., Starkman, S., Ali, L. K., Kim, D., Gonzalez, N. R., Jahan, R., Tateshima, S., Duckwiler, G., Vinuela, F., Liebeskind, D. S., for the UCLA Comprehensive Stroke Center Tags: Ischemic stroke Source Type: research

Device size selection can enhance Y-stentrieving efficacy and safety as a rescue strategy in stroke thrombectomy
Conclusion Y-stentrieving is an effective and safe bail-out strategy for refractory bifurcation clots. Longer stents may promote better angiographic outcomes, whereas avoidance of disproportionately large retrievers may mitigate intracranial hemorrhage. Future studies should account for these factors when evaluating alternative stentriever techniques.
Source: Journal of NeuroInterventional Surgery - May 13, 2022 Category: Neurosurgery Authors: Cabral, L. S., MontAlverne, F., Silva, H. C., Passos Filho, P. E., Magalhaes, P. S. C., Bianchin, M. M., Nogueira, R. G. Tags: Ischemic stroke Source Type: research

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