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Source: The Lancet Neurology
Condition: Ischemic Stroke
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Total 88 results found since Jan 2013.
Development of epilepsy after ischaemic stroke
Publication date: Available online 17 November 2015 Source:The Lancet Neurology Author(s): Asla Pitkänen, Reina Roivainen, Katarzyna Lukasiuk For about 30% of patients with epilepsy the cause is unknown. Even in patients with a known risk factor for epilepsy, such as ischaemic stroke, only a subpopulation of patients develops epilepsy. Factors that contribute to the risk for epileptogenesis in a given individual generally remain unknown. Studies in the past decade on epilepsy in patients with ischaemic stroke suggest that, in addition to the primary ischaemic injury, existing difficult-to-detect microscale changes in...
Source: The Lancet Neurology - November 17, 2015 Category: Neurology Source Type: research
Incidence, outcome, risk factors, and long-term prognosis of cryptogenic transient ischaemic attack and ischaemic stroke: a population-based study
Publication date: Available online 27 July 2015 Source:The Lancet Neurology Author(s): Linxin Li, Gabriel S Yiin, Olivia C Geraghty, Ursula G Schulz, Wilhelm Kuker, Ziyah Mehta, Peter M Rothwell Background A third of transient ischaemic attacks (TIAs) and ischaemic strokes are of undetermined cause (ie, cryptogenic), potentially undermining secondary prevention. If these events are due to occult atheroma, the risk-factor profile and coronary prognosis should resemble that of overt large artery events. If they have a cardioembolic cause, the risk of future cardioembolic events should be increased. We aimed to asses...
Source: The Lancet Neurology - July 28, 2015 Category: Neurology Source Type: research
Ischaemic stroke of undetermined cause
Publication date: Available online 27 July 2015 Source:The Lancet Neurology Author(s): Jose M Ferro
Source: The Lancet Neurology - July 28, 2015 Category: Neurology Source Type: research
Endovascular stent thrombectomy: the new standard of care for large vessel ischaemic stroke
Publication date: Available online 25 June 2015 Source:The Lancet Neurology Author(s): Bruce C V Campbell , Geoffrey A Donnan , Kennedy R Lees , Werner Hacke , Pooja Khatri , Michael D Hill , Mayank Goyal , Peter J Mitchell , Jeffrey L Saver , Hans-Christoph Diener , Stephen M Davis Background Results of initial randomised trials of endovascular treatment for ischaemic stroke, published in 2013, were neutral but limited by the selection criteria used, early-generation devices with modest efficacy, non-consecutive enrolment, and treatment delays. Recent developments In the past year, six positive trials of endovascular t...
Source: The Lancet Neurology - June 26, 2015 Category: Neurology Source Type: research
Future directions of acute ischaemic stroke therapy
Publication date: July 2015 Source:The Lancet Neurology, Volume 14, Issue 7 Author(s): Marc Fisher , Jeffrey L Saver For several years, the only therapy with proven efficacy for acute ischaemic stroke was alteplase, which is approved for use within 4·5 h after stroke onset in many countries, but only within 3 h in the USA. However, the recanalisation rate with alteplase is modest. Several trials have shown substantial clinical benefit of neurothrombectomy within 6 h of ischaemic stroke onset, which has initiated a new era of acute stroke therapy. As neurothrombectomy becomes part of standard practice, additional trials ...
Source: The Lancet Neurology - June 9, 2015 Category: Neurology Source Type: research
Epidemiology, pathophysiology, diagnosis, and management of intracranial artery dissection
Publication date: June 2015 Source:The Lancet Neurology, Volume 14, Issue 6 Author(s): Stéphanie Debette , Annette Compter , Marc-Antoine Labeyrie , Maarten Uyttenboogaart , Tina M Metso , Jennifer J Majersik , Barbara Goeggel-Simonetti , Stefan T Engelter , Alessandro Pezzini , Philippe Bijlenga , Andrew M Southerland , Olivier Naggara , Yannick Béjot , John W Cole , Anne Ducros , Giacomo Giacalone , Sabrina Schilling , Peggy Reiner , Hakan Sarikaya , Janna C Welleweerd , L Jaap Kappelle , Gert Jan de Borst , Leo H Bonati , Simon Jung , Vincent Thijs , Juan J Martin , Tobias Brandt , Caspar Grond-Ginsbach , Manja Klos...
Source: The Lancet Neurology - May 11, 2015 Category: Neurology Source Type: research
Safety and efficacy of desmoteplase given 3–9 h after ischaemic stroke in patients with occlusion or high-grade stenosis in major cerebral arteries (DIAS-3): a double-blind, randomised, placebo-controlled phase 3 trial
Publication date: Available online 30 April 2015 Source:The Lancet Neurology Author(s): Gregory W Albers , Rüdiger von Kummer , Thomas Truelsen , Jens-Kristian S Jensen , Gabriela M Ravn , Bjørn A Grønning , Hugues Chabriat , Ku-Chou Chang , Antonio E Davalos , Gary A Ford , James Grotta , Markku Kaste , Lee H Schwamm , Ashfaq Shuaib Background Current treatment of ischaemic stroke with thrombolytic therapy is restricted to 3–4·5 h after symptom onset. We aimed to assess the safety and efficacy of desmoteplase, a fibrin-dependent plasminogen activator, given between 3 h and 9 h after symptom onset in patients with ...
Source: The Lancet Neurology - May 1, 2015 Category: Neurology Source Type: research
Stenting versus medical treatment in patients with symptomatic vertebral artery stenosis: a randomised open-label phase 2 trial
Publication date: Available online 20 April 2015 Source:The Lancet Neurology Author(s): Annette Compter , H Bart van der Worp , Wouter J Schonewille , Jan Albert Vos , Jelis Boiten , Paul J Nederkoorn , Maarten Uyttenboogaart , Rob T Lo , Ale Algra , L Jaap Kappelle Background Patients with a recent vertebrobasilar transient ischaemic attack or ischaemic stroke and vertebral artery stenosis of at least 50% have a high risk of future vertebrobasilar stroke. Stenting of vertebral artery stenosis is promising, but of uncertain benefit. We investigated the safety and feasibility of stenting of symptomatic vertebral artery st...
Source: The Lancet Neurology - April 21, 2015 Category: Neurology Source Type: research
Association between brain imaging signs, early and late outcomes, and response to intravenous alteplase after acute ischaemic stroke in the third International Stroke Trial (IST-3): secondary analysis of a randomised controlled trial
Publication date: Available online 27 March 2015 Source:The Lancet Neurology Background Brain scans are essential to exclude haemorrhage in patients with suspected acute ischaemic stroke before treatment with alteplase. However, patients with early ischaemic signs could be at increased risk of haemorrhage after alteplase treatment, and little information is available about whether pre-existing structural signs, which are common in older patients, affect response to alteplase. We aimed to investigate the association between imaging signs on brain CT and outcomes after alteplase. Methods IST-3 was a multicentre, randomised ...
Source: The Lancet Neurology - March 27, 2015 Category: Neurology Source Type: research
Diagnosis of atrial fibrillation after stroke and transient ischaemic attack: a systematic review and meta-analysis
Publication date: Available online 4 March 2015 Source:The Lancet Neurology Author(s): Luciano A Sposato , Lauren E Cipriano , Gustavo Saposnik , Estefanía Ruíz Vargas , Patricia M Riccio , Vladimir Hachinski Background Among patients with atrial fibrillation, the risk of stroke is highest for those with a history of stroke; however, oral anticoagulants can lower the risk of recurrent stroke by two-thirds. No consensus has been reached about how atrial fibrillation should be investigated in patients with stroke, and its prevalence after a stroke remains uncertain. We did a systematic review and meta-analysis to estimat...
Source: The Lancet Neurology - March 5, 2015 Category: Neurology Source Type: research
Alteplase versus tenecteplase for thrombolysis after ischaemic stroke (ATTEST): a phase 2, randomised, open-label, blinded endpoint study
This study is registered with ClinicalTrials.gov, number NCT01472926. Findings Between Jan 1, 2012, and Sept 7, 2013, 355 patients were screened, of whom 157 were eligible for intravenous thrombolysis, and 104 patients were enrolled. 52 were assigned to the alteplase group and 52 to tenecteplase. Of 71 patients (35 assigned tenecteplase and 36 assigned alteplase) contributing to the primary endpoint, no significant differences were noted for percentage of penumbral salvaged (68% [SD 28] for the tenecteplase group vs 68% [23] for the alteplase group; mean difference 1·3% [95% CI −9·6 to 12·1]; p=0·81). Neither incide...
Source: The Lancet Neurology - February 26, 2015 Category: Neurology Source Type: research
Antiplatelet treatment compared with anticoagulation treatment for cervical artery dissection (CADISS): a randomised trial
Publication date: Available online 12 February 2015 Source:The Lancet Neurology Background Extracranial carotid and vertebral artery dissection is an important cause of stroke, especially in young people. In some observational studies it has been associated with a high risk of recurrent stroke. Both antiplatelet drugs and anticoagulant drugs are used to reduce risk of stroke but whether one treatment strategy is more effective than the other is unknown. We compared their efficacy in the Cervical Artery Dissection in Stroke Study (CADISS), with the additional aim of establishing the true risk of recurrent stroke. Methods W...
Source: The Lancet Neurology - February 13, 2015 Category: Neurology Source Type: research
Thrombolysis and clinical outcome in patients with stroke after implementation of the Tyrol Stroke Pathway: a retrospective observational study
Publication date: Available online 28 November 2014 Source:The Lancet Neurology Author(s): Johann Willeit , Theresa Geley , Johannes Schöch , Heinrich Rinner , Andreas Tür , Hans Kreuzer , Norbert Thiemann , Michael Knoflach , Thomas Toell , Raimund Pechlaner , Karin Willeit , Natalie Klingler , Silvia Praxmarer , Michael Baubin , Gertrud Beck , Klaus Berek , Christian Dengg , Klaus Engelhardt , Thomas Erlacher , Thomas Fluckinger , Wilhelm Grander , Josef Grossmann , Hermann Kathrein , Norbert Kaiser , Benjamin Matosevic , Heinrich Matzak , Markus Mayr , Robert Perfler , Werner Poewe , Alexandra Rauter , Gudrun Schoen...
Source: The Lancet Neurology - December 8, 2014 Category: Neurology Source Type: research
