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Effects With and Without Clopidogrel Loading Treatment for Acute Ischemic Cerebrovascular Disease Patients: A Retrospective Cohort Study
We investigated the effectiveness of clopidogrel loading (CL) treatment compared with usual clopidogrel non-loading (NL) treatment for acute ischemic cerebrovascular disease.
Source: Journal of Stroke and Cerebrovascular Diseases - August 18, 2017 Category: Neurology Authors: Yasuko Ikeda-Sakai, Masahiro Sasaki, Taizen Nakase Source Type: research

Aspirin Versus Clopidogrel for Type 2 Diabetic Patients with First-Ever Noncardioembolic Acute Ischemic Stroke: Ten-Year Survival Data from the Athens Stroke Outcome Project
Diabetes mellitus is associated with an increased risk of stroke and poor outcome following a stroke event. We assessed the impact of discharge treatment with aspirin versus clopidogrel on the 10-year survival of patients with type 2 diabetes after a first-ever noncardioembolic acute ischemic stroke (AIS).
Source: Journal of Stroke and Cerebrovascular Diseases - July 28, 2017 Category: Neurology Authors: Haralampos Milionis, George Ntaios, Vasileios Papavasileiou, Konstantinos Spengos, Efstathios Manios, Moses Elisaf, Konstantinos Vemmos Source Type: research

Platelet Function Testing in Patients with Acute Ischemic Stroke: An Observational Study
The measurement of platelet reactivity in patients with stroke undergoing antiplatelet therapies is not commonly performed in clinical practice. We assessed the prevalence of therapy responsiveness in patients with stroke and further investigated differences between patients on prevention therapy at stroke onset and patients naive to antiplatelet medications. We also sought differences in responsiveness between etiological subtypes and correlations between Clopidogrel responsiveness and genetic polymorphisms.
Source: Journal of Stroke and Cerebrovascular Diseases - May 30, 2017 Category: Neurology Authors: Francesca Rosafio, Nicoletta Lelli, Stefano Mimmi, Laura Vandelli, Guido Bigliardi, Maria Luisa Dell'Acqua, Livio Picchetto, Roberta Pentore, Diana Ferraro, Tommaso Trenti, Paolo Nichelli, Andrea Zini Source Type: research

Concomitant Use of Proton Pump Inhibitors and Clopidogrel Is Not Associated with Adverse Outcomes after Ischemic Stroke in Chinese Population
Conflicting data exist as to whether proton pump inhibitors (PPIs) diminish the efficacy of clopidogrel. We, therefore, assessed the effect of concomitant PPI use in ischemic stroke (IS) patients receiving clopidogrel.
Source: Journal of Stroke and Cerebrovascular Diseases - August 17, 2016 Category: Neurology Authors: Xingyang Yi, Qiang Zhou, Chun Wang, Jing Lin, Wen Cheng, Lifen Chi Source Type: research

Aspirin and Clopidogrel Inhibit Aneurysm Healing after HydroCoil Implantation in External Carotid Artery Aneurysm Model
To understand whether the use of antiplatelet agents leads to less intra-aneurismal tissue formation following coil implantation in a rat end-pouch external carotid artery (ECA) aneurysm model.
Source: Journal of Stroke and Cerebrovascular Diseases - July 24, 2016 Category: Neurology Authors: Chao Zhang, Peiliang Li, Guohua Xi, Joseph J. Gemmete, Neeraj Chaudhary, B. Gregory Thompson, Aditya S. Pandey Source Type: research

Clopidogrel Resistance Increases Rate of Recurrent Stroke and Other Vascular Events in Chinese Population
Research regarding clopidogrel resistance (CR) and ischemic stroke (IS) recurrence related to IS is scanty. The aim of the present study was to determine the incidence of CR and the association between CR and IS recurrence and other vascular events in patients with IS receiving clopidogrel.
Source: Journal of Stroke and Cerebrovascular Diseases - February 26, 2016 Category: Neurology Authors: Xingyang Yi, Jing Lin, Qiang Zhou, Lang Wu, Wen Cheng, Chun Wang Source Type: research

Relationship between Inflammation and Aspirin and Clopidogrel Antiplatelet Responses in Acute Ischemic Stroke
We measured serum levels of proinflammatory/prothrombotic markers P-selectin, CD40L, matrix metalloproteinase 9 (MMP-9), intracellular adhesion molecule 1 (ICAM-1), and interleukin (IL)-6 in ischemic stroke patients, correlating their levels with the results of aspirin (ASA) and clopidogrel antiplatelet responses, using 3 “point of care” platelet function instruments, thromboelastograph (TEG), Accumetrics (ACU), and impedance aggregometer (IMP).
Source: Journal of Stroke and Cerebrovascular Diseases - November 12, 2015 Category: Neurology Authors: Zohara Sternberg, Trevor Chichelli, Daniel Sternberg, Robert Sawyer, Marilou Ching, David Janicke, Julian L. Ambrus, Jinhee Yu, Frederick Munschauer Source Type: research

Influence of Diabetes Mellitus and Cigarette Smoking on Variability of the Clopidogrel-Induced Antiplatelet Effect and Efficacy of Active Management of the Target P2Y12 Reaction Unit Range in Patients Undergoing Neurointerventional Procedures
Optimal antiplatelet inhibition is essential in patients undergoing neurointerventional procedures; however, variability in response to clopidogrel can contribute to thromboembolic and hemorrhagic complications. The present study evaluated the influence of diabetes mellitus and cigarette smoking on clopidogrel reactivity.
Source: Journal of Stroke and Cerebrovascular Diseases - October 19, 2015 Category: Neurology Authors: Ichiro Nakagawa, Hun Soo Park, Shohei Yokoyama, Takeshi Wada, Yasuo Hironaka, Yasushi Motoyama, Katsutoshi Takayama, Kimihiko Kichikawa, Hiroyuki Nakase Source Type: research

Clopidogrel Resistance after Minor Ischemic Stroke or Transient Ischemic Attack is Associated with Radiological Cerebral Small-Vessel Disease
The objective of this study was to compare nonresponders (NR) and responders (R) to clopidogrel with respect to presence of microvascular and macrovascular pathology in a cohort of patients with recent minor ischemic stroke (IS) or transient ischemic attack (TIA).
Source: Journal of Stroke and Cerebrovascular Diseases - August 23, 2015 Category: Neurology Authors: Annika Lundström, Håkan Wallén, Magnus von Arbin, Gun Jörneskog, Bruna Gigante, Karin Höeg embrower, Evaldas Laurencikas, Ann Charlotte Laska Source Type: research

Is Acute Carotid Artery Stent Thrombosis an Avoidable Complication?
The most serious complication of carotid artery stenting (CAS) is acute carotid artery stent thrombosis (ACAST). ACAST is a very rare complication, but it may lead to dramatic and catastrophic consequences. The most important cause is inadequate or ineffective antiaggregant therapy. It is very important to identify, before CAS, those patients who might be candidates for ACAST and to start antiplatelet therapy for them. Testing patients who are candidates for CAS for acetylsalicylic acid and clopidogrel resistance may prevent this complication.
Source: Journal of Stroke and Cerebrovascular Diseases - August 23, 2015 Category: Neurology Authors: Erkan Köklü, İsa Öner Yüksel, Nermin Bayar, Şakir Arslan Source Type: research

Predictive Value of High Residual Platelet Reactivity by Flow Cytometry for Outcomes of Ischemic Stroke Patients on Clopidogrel Therapy
High residual platelet reactivity (HRPR) assessed by multiple tests has been associated with worse clinical outcomes. However, the clinical impact of HRPR assessed by flow cytometry is unknown. The aim of this study was to validate the predictive value of HRPR measured by flow cytometry for clinical outcomes in ischemic stroke patients during clopidogrel therapy. Overall, 198 consecutive patients with ischemic stroke taking clopidogrel underwent platelet function testing on flow cytometer including adenosine diphosphate (ADP)–induced platelet aggregation (PAg) and platelet activation markers (CD62P, CD63, and PAC-1).
Source: Journal of Stroke and Cerebrovascular Diseases - April 10, 2015 Category: Neurology Authors: Li-Na Qiu, Lin Wang, Xin Li, Rui-Fa Han, Xiao-Shuang Xia, Jie Liu Source Type: research

Genotype and Early Ischemic Lesion Recurrence in Stroke Patients Treated with Clopidogrel
Early recurrent ischemic lesions detected on diffusion-weighted imaging (DWI) have been proposed as a surrogate marker for clinical recurrence. We hypothesized that cytochrome P450 2C19 (CYP2C19) genotype influences the incidence of early recurrence on DWI in acute stroke patients treated with clopidogrel.
Source: Journal of Stroke and Cerebrovascular Diseases - December 16, 2014 Category: Neurology Authors: Tae-Dong Jeong, Seung Min Kim, Hyo Jin Kim, Woochang Lee, Sun U. Kwon, Won-Ki Min, Dong-Wha Kang, Sail Chun Source Type: research

Assessment of Platelet Function in Acute Ischemic Stroke Patients Previously Treated with Aspirin
Platelet inhibition measured by platelet function tests could be critical to understand the reasons for early recurrence and to guide therapeutic recommendations. We assess the platelet function during the acute phase of ischemic stroke in patients pretreated with aspirin who continue their treatment with aspirin only, are started on clopidogrel only, or add clopidogrel to aspirin.
Source: Journal of Stroke and Cerebrovascular Diseases - October 16, 2014 Category: Neurology Authors: Aida Lago, Vera Parkhutik, Jose Ignacio Tembl, Juana Vallés, Maria Teresa Santos, Antonio Moscardó Source Type: research

Do the Antithrombotic Therapy at the Time of Intracerebral Hemorrhage Influence Clinical Outcome? Analysis between the Difference of Antiplatelet and Anticoagulant Agents and Clinical Course
Background: It is controversial whether taking antiplatelet agents (APs) or anticoagulant agents (ACs) could influence clinical outcome after intracerebral hemorrhage (ICH).Methods: We retrospectively investigated 557 ICH patients between September 2008 and August 2013. We reviewed patients' characteristics, hematoma volume, deterioration (hematoma expansion, surgical hematoma evacuation, or death), and clinical outcome in modified Rankin Scale.Results: A total of 397 were classified as neither AP nor AC (“Nothing”), 81 as single AP (44 as aspirin [ASA], 22 as clopidogrel or ticlopidine [CLP/TIC], 7 as cilostazol, 8 as...
Source: Journal of Stroke and Cerebrovascular Diseases - June 23, 2014 Category: Neurology Authors: Takeshi Okada, Taizen Nakase, Masahiro Sasaki, Tatsuya Ishikawa Tags: Original Articles Source Type: research

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