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Source: Circulation
Condition: Atrial Fibrillation

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Total 235 results found since Jan 2013.

Antithrombotic Therapy for Patients with Atrial Fibrillation and Atherothrombotic Vascular Disease: Striking the Right Balance between Efficacy and Safety.
Abstract Atrial fibrillation (AF), the most prevalent cardiac arrhythmia, is estimated to affect 1.5 to 2.0% of the general population, i.e., at least 100 million people worldwide.(1) Left untreated, patients with nonvalvular AF (NVAF) are exposed to an annual risk of thromboembolic stroke of approximately 5%, resulting in 5 million AF-related strokes each year.(1) Properly dosed anticoagulation (e.g., warfarin adjusted to an international normalized ratio [INR] of 2.0 to 3.0) is extremely effective in preventing AF-related strokes, reducing risk by two-thirds compared with no therapy, and by one-half compared to ...
Source: Circulation - July 16, 2013 Category: Cardiology Authors: Patrono C, Andreotti F Tags: Circulation Source Type: research

Letter by parikh and rashba regarding article, "rhythm versus rate control therapy and subsequent stroke or transient ischemic attack in patients with atrial fibrillation".
PMID: 23857242 [PubMed - in process]
Source: Circulation - July 16, 2013 Category: Cardiology Authors: Parikh PB, Rashba E Tags: Circulation Source Type: research

Letter by gasparovic and kopjar regarding article, "rhythm versus rate control therapy and subsequent stroke or transient ischemic attack in patients with atrial fibrillation".
PMID: 23857241 [PubMed - in process]
Source: Circulation - July 16, 2013 Category: Cardiology Authors: Gasparovic H, Kopjar T Tags: Circulation Source Type: research

Letter by santovito et Al regarding article, "rhythm versus rate control therapy and subsequent stroke or transient ischemic attack in patients with atrial fibrillation".
PMID: 23857240 [PubMed - in process]
Source: Circulation - July 16, 2013 Category: Cardiology Authors: Santovito D, Mezzetti A, Cipollone F Tags: Circulation Source Type: research

The Long Term Multi-Center Observational Study of Dabigatran Treatment in Patients with Atrial Fibrillation: (RELY-ABLE) Study.
CONCLUSIONS: During 2.3 years continued treatment with dabigatran after RE-LY, there was a higher rate of major bleeding with dabigatran 150 mg twice daily compared to 110 mg, and similar rates of stroke and death. CLINICAL TRIAL REGISTRATION INFORMATION: Clinicaltrials.gov; Identifier: NCT00808067. PMID: 23770747 [PubMed - as supplied by publisher]
Source: Circulation - June 14, 2013 Category: Cardiology Authors: Connolly SJ, Wallentin L, Ezekowitz MD, Eikelboom JW, Oldgren J, Reilly PA, Brueckmann M, Pogue J, Alings M, Amerena JV, Avezum A, Baumgartner I, Budaj AJ, Chen JH, Dans AL, Darius H, Di Pasquale G, Ferreira J, Flaker GC, Flather MD, Franzosi MG, Golitsyn Tags: Circulation Source Type: research

New Oral Anticoagulants in Atrial Fibrillation Forever?
Abstract Atrial fibrillation is the most common chronic cardiac arrhythmia in clinical cardiology. It affects about 1% of the population, and of individuals over the age of 80 about 10% have this rhythm disturbance. Due to the loss of the atrial contribution to ventricular filling, left ventricular function is diminished resulting in a propensity to heart failure, fatigue and disability. Furthermore, the sensation of palpations can be very disturbing for younger patients and may hamper them in their physical and professional activities. Finally, the diminished blood flow through the heart, especially the left atri...
Source: Circulation - June 14, 2013 Category: Cardiology Authors: Verheugt FW Tags: Circulation Source Type: research

Stepwise Screening of Atrial Fibrillation in a 75-Year Old Population: Implications for Stroke Prevention.
CONCLUSIONS: Stepwise risk factor-stratified AF screening in a 75-year old population yields a large share of candidates for OAC treatment on AF indication. PMID: 23343564 [PubMed - as supplied by publisher]
Source: Circulation - January 23, 2013 Category: Cardiology Authors: Engdahl J, Andersson L, Mirskaya M, Rosenqvist M Tags: Circulation Source Type: research

Percutaneous Left Atrial Appendage Closure for Stroke Prophylaxis in Patients with Atrial Fibrillation: 2.3 Year Follow-Up of the PROTECT AF Trial.
CONCLUSIONS: The "local" strategy of LAA closure is noninferior to "systemic" anticoagulation with Warfarin. PROTECT AF has, for the first time, implicated the LAA in the pathogenesis of stroke in AF. CLINICAL TRIAL REGISTRATION INFORMATION: Clinicaltrials.gov; Unique Identifier: NCT00129545. PMID: 23325525 [PubMed - as supplied by publisher]
Source: Circulation - January 16, 2013 Category: Cardiology Authors: Reddy VY, Doshi SK, Siever H, Buchbinder M, Neuzil P, Huber K, Halperin JL, Holmes D Tags: Circulation Source Type: research

Letter by Bonaque et al Regarding Article, "Cardiac Biomarkers Are Associated With an Increased Risk of Stroke and Death in Patients With Atrial Fibrillation: A Randomized Evaluation of Long-Term Anticoagulation Therapy (RE-LY) Substudy".
PMID: 23319819 [PubMed - in process]
Source: Circulation - January 15, 2013 Category: Cardiology Authors: Bonaque JC, Merchán G, Ikuta I Tags: Circulation Source Type: research

"R" for "renal" and for "risk": refining risk stratification for stroke in atrial fibrillation.
PMID: 23319810 [PubMed - in process]
Source: Circulation - January 15, 2013 Category: Cardiology Authors: Camm AJ, Savelieva I Tags: Circulation Source Type: research