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Risk of Intracranial Hemorrhage from Statin Use in Asians: A Nationwide Cohort Study.
CONCLUSIONS: -Generally, no association was observed between cumulative statin use and risk of ICH among subjects without a prior history of stroke. An increased risk was identified among the non-hypertensive cohort, but this finding should be interpreted with caution. PMID: 25858194 [PubMed - as supplied by publisher]
Source: Circulation - April 9, 2015 Category: Cardiology Authors: Chang CH, Lin CH, Caffrey JL, Lee YC, Liu YC, Lin JW, Lai MS Tags: Circulation Source Type: research

Optimal Medical Therapy Improves Clinical Outcomes in Patients Undergoing Revascularization With Percutaneous Coronary Intervention or Coronary Artery Bypass Grafting: Insights From the Synergy Between Percutaneous Coronary Intervention With TAXUS and Cardiac Surgery (SYNTAX) Trial at the 5-Year Follow-Up.
CONCLUSIONS: The use of OMT remains low in patients with complex coronary disease requiring coronary intervention with percutaneous coronary intervention and even lower in patients treated with CABG. Lack of OMT is associated with adverse clinical outcomes. Targeted strategies to improve OMT use in postrevascularization patients are warranted. CLINICAL TRIAL REGISTRATION: URL: http://www.clinicaltrials.gov. Unique identifier: NCT00114972. PMID: 25847979 [PubMed - in process]
Source: Circulation - April 7, 2015 Category: Cardiology Authors: Iqbal J, Zhang YJ, Holmes DR, Morice MC, Mack MJ, Kappetein AP, Feldman T, Stahle E, Escaned J, Banning AP, Gunn JP, Colombo A, Steyerberg EW, Mohr FW, Serruys PW Tags: Circulation Source Type: research

Cardiovascular Health and Protection Against CVD: More Than the Sum of the Parts?
Abstract Five years ago, the American Heart Association (AHA) launched a bold new initiative to begin promoting "cardiovascular health" in individuals and the population, in addition to continuing its decades-long fight to reduce cardiovascular and stroke mortality and decrease cardiovascular disease (CVD) risk. This shift in priorities came as a result of a "quiet revolution,"(1) turning the adverse-outcomes-oriented and risk-focused perspective on its head, and instead focusing on creating the opportunity for promoting and preserving attributes associated with healthy, CVD-free longevity. The first-ever formal d...
Source: Circulation - October 1, 2014 Category: Cardiology Authors: Lloyd-Jones DM Tags: Circulation Source Type: research

Medical Decision Making and the Counting of Uncertainty.
Abstract In economic theory, homo economicus is a concept used to explain decision-making as a rational exercise.(1) The "economic man", to use the term often associated with the work of the utilitarian philosopher John Stuart Mills, is someone who makes decisions by carefully weighing the benefits and costs of his options, then deciding on a course of action that maximizes his utility. Although now considered overly simplistic, this idea is often implicit in how we as clinicians have traditionally approached medical decision-making. In the case of statins for the primary prevention of cardiovascular diseases, the...
Source: Circulation - April 17, 2014 Category: Cardiology Authors: Ye S Tags: Circulation Source Type: research

Sodium, Blood Pressure and Cardiovascular Disease: A Compelling Scientific Case for Improving the Health of the Public.
Abstract The relationship between sodium (Na) intake and human health indicators has been investigated in observational studies and randomized controlled trials (RCT). The most extensive body of information details the relationship between Na and blood pressure (BP). High BP was identified as the leading risk factor, among 67 studied, for worldwide mortality and disability adjusted life years(1). It is also one of the best surrogate markers for cardiovascular disease (CVD), especially stroke(1). Consistent with prior reports, three recent meta-analyses of RCT identified significant declines in BP following a reduc...
Source: Circulation - January 14, 2014 Category: Cardiology Authors: Whelton PK Tags: Circulation Source Type: research

The Impact of Partner Bereavement on Quality of Cardiovascular Disease Management.
CONCLUSIONS: Lower uptake of key cardiovascular care measures in the year before bereavement and reduced medication coverage after bereavement may contribute to increased cardiovascular risk. Clinicians need to ensure that quality of cardiovascular care is maintained in the pre and post bereavement period. PMID: 24255060 [PubMed - as supplied by publisher]
Source: Circulation - November 19, 2013 Category: Cardiology Authors: Shah SM, Carey IM, Harris T, Dewilde S, Victor CR, Cook DG Tags: Circulation Source Type: research

Dyslipidemia, Coronary Artery Calcium, and Incident Atherosclerotic Cardiovascular Disease: Implications for Statin Therapy from the Multi-Ethnic Study of Atherosclerosis.
CONCLUSIONS: CAC may have the potential to help match statin therapy to absolute CVD risk. Across the spectrum of dyslipidemia, event rates similar to secondary prevention populations were observed for patients with CAC>=100. PMID: 24141324 [PubMed - as supplied by publisher]
Source: Circulation - October 20, 2013 Category: Cardiology Authors: Martin SS, Blaha MJ, Blankstein R, Agatston AS, Rivera JJ, Virani SS, Ouyang P, Jones SR, Blumenthal RS, Budoff MJ, Nasir K Tags: Circulation Source Type: research

C-Reactive Protein, but not Low-Density Lipoprotein Cholesterol Levels, Associate with Coronary Atheroma Regression and Cardiovascular Events Following Maximally Intensive Statin Therapy.
CONCLUSIONS: Following 24 months of potent statin therapy, on-treatment CRP levels associated with MACE. Inflammation may be an important driver of residual cardiovascular risk in patients with coronary artery disease despite aggressive statin therapy. CLINICAL TRIAL REGISTRATION INFORMATION: ClinicalTrials.gov. Identifier: NCT000620542. PMID: 24043299 [PubMed - as supplied by publisher]
Source: Circulation - September 16, 2013 Category: Cardiology Authors: Puri R, Nissen SE, Libby P, Shao M, Ballantyne CM, Barter PJ, Chapman MJ, Erbel R, Raichlen JS, Uno K, Kataoka Y, Nicholls SJ Tags: Circulation Source Type: research

Long-Term Effects of Secondary Prevention on Cognitive Function in Stroke Patients.
CONCLUSIONS: Appropriate vascular risk management was associated with a long-term reduced risk of cognitive impairment. Focus on optimal preventive drug therapy of vascular risk factors and management should be supported. PMID: 23935013 [PubMed - as supplied by publisher]
Source: Circulation - August 9, 2013 Category: Cardiology Authors: Douiri A, McKevitt C, Emmett ES, Rudd AG, Wolfe CD Tags: Circulation Source Type: research

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