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Specialty: General Medicine
Source: The American Journal of Medicine
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Total 259 results found since Jan 2013.
Embolic stroke of undetermined source: Gateway to a new stroke entity?
Embolic stroke of unknown source is currently thought to represent a subpopulation of cryptogenic strokes defined by its embolic stroke pattern on imaging and if after a carefully performed diagnostic evaluation, a specific, well recognized cause of stroke has not been identified. The concept was primarily established to justify and enable the conduct of the Embolic Stroke of Unknown Source (ESUS)-trials, such as RESPECT-ESUS (Randomized, Double-Blind, Evaluation in Secondary Stroke Prevention Comparing the Efficacy and Safety of the Oral Thrombin Inhibitor Dabigatran Etexilate versus Acetylsalicylic Acid in Patients with ...
Source: The American Journal of Medicine - April 1, 2020 Category: General Medicine Authors: Wolf-R üdiger Schäbitz, Martin Köhrmann, Peter D. Schellinger, Jens Minnerup, Marc Fisher Tags: Review Source Type: research
Albuminuria and Risk of Cardiovascular Events and Mortality in a General Population of Patients with Type 2 Diabetes without Cardiovascular Disease: A Danish Cohort Study
Albuminuria level is associated with cardiovascular events and mortality in patients with diabetes. However, little is known about the association between albuminuria level in diabetes patients without overt cardiovascular disease. We aimed to examine the association between albuminuria level and the risk of ischemic stroke, myocardial infarction, and all-cause mortality in patients with type 2 diabetes without overt cardiovascular disease.
Source: The American Journal of Medicine - March 19, 2020 Category: General Medicine Authors: Mia Vicki Fangel, Peter Br ønnum Nielsen, Jette Kolding Kristensen, Torben Bjerregaard Larsen, Thure Filskov Overvad, Gregory YH Lip, Martin Bach Jensen Tags: Clinical Research Study Source Type: research
Contemporary Meta-Analysis of Extended Direct Acting Oral Anticoagulant Thromboprophylaxis to Prevent Venous Thromboembolism Among Hospitalized Patients
There are over 36 million medical hospitalizations each year in the United States, with the majority being for acute medical illness.1 Cancer, chronic obstructive pulmonary disease, congestive heart failure, stroke and myocardial infarction are some of the most common indications for hospitalization and are additionally risk factors for venous thromboembolism.2 With over 900,000 patients suffering from venous thromboembolism each year, excess thrombosis causes a large medical and financial burden to patients and the health care system.
Source: The American Journal of Medicine - March 5, 2020 Category: General Medicine Authors: Vikas Bhalla, Olivia F Lamping, Ahmed Abdel-Latif, Meenakshi Bhalla, Khaled Ziada, Susan S. Smyth Tags: Clinical Research Study Source Type: research
Cholangiocarcinoma manifesting as non-bacterial thrombotic endocarditis in a young patient
A 41-year-old female with steroid-dependent rheumatoid arthritis and a recent (four months prior) cerebellar stroke presented with complaints of constant headache and right eye blindness of one day. At the time of the cerebellar stroke, she had presented with persistent headaches, dizziness and gait instability. That workup, including hypercoagulability evaluation, was unremarkable apart from the radiographic abnormalities diagnosing her left medial cerebellar hemisphere infarct. She was disc harged with a plan for outpatient loop recorder placement and aspirin for secondary stroke prevention.
Source: The American Journal of Medicine - January 23, 2020 Category: General Medicine Authors: Ninad Nadkarni, Young Ju Lee, Ryan Hoefen, Richard Alweis Tags: Diagnostic Dilemma Source Type: research
To the Horizon: The Brink of an AI Revolution in Prostate Cancer?
Noorbakhsh-Sabet et al.1 published an excellent review in The American Journal of Medicine summarizing the potential of artificial intelligence (AI) in medicine. They describe wide utility (e.g. in dermatology and stroke), but do not consider surgery and urology, which embrace cutting-edge technology, including fusion-biopsy and robotics,2 and will be early AI adopters. Indeed, prostate cancer creates a huge health care burden, thus being ideal for AI transformation.
Source: The American Journal of Medicine - January 16, 2020 Category: General Medicine Authors: Joseph M. Norris, Asif Raza Tags: Letter Source Type: research
Potential role of two-phase cardiac CT in patients with embolic stroke of undetermined source
Recent trials failed to demonstrate that anticoagulation was superior to antiplatelet agents in preventing recurrent stroke after embolic stroke of undetermined source (ESUS), which may be due to the heterogeneity of etiology. We thus investigated whether the use of two-phase cardiac CT could help to evaluate the etiology in patients with ESUS.
Source: The American Journal of Medicine - December 19, 2019 Category: General Medicine Authors: Shenqiang Yan, Ying Zhou, Quan Han, Yi Chen, Min Lou Tags: Brief Observation Source Type: research
Digital Management of Hypertension Improves Systolic Blood Pressure Variability
Higher systolic blood pressure variability has been shown to be a better predictor of all-cause and cardiovascular disease mortality, stroke, and cardiac disease compared with average systolic blood pressure.
Source: The American Journal of Medicine - December 19, 2019 Category: General Medicine Authors: Richard V. Milani, Jonathan K. Wilt, Alexander R. Milani, Robert M. Bober, Eric Malamud, Jonathan Entwisle, Carl J. Lavie Tags: Clinical Research Study Source Type: research
Potential Role of 2-Phase Cardiac CT in Patients With Embolic Stroke of Undetermined Source
Recent trials failed to demonstrate that anticoagulation was superior to antiplatelet agents in preventing recurrent stroke after embolic stroke of undetermined source (ESUS), which may be as a result of the heterogeneity of etiology. We thus investigated whether the use of 2-phase cardiac computed tomography (CT) could help to evaluate the etiology in patients with ESUS.
Source: The American Journal of Medicine - December 19, 2019 Category: General Medicine Authors: Shenqiang Yan, Ying Zhou, Quan Han, Yi Chen, Min Lou Tags: Brief Observation Source Type: research
The Anti-Platelet Anomaly: Aspirin/Dipyridamole-Induced Acute Pancreatitis
We present a case of aspirin/dipyridamole-induced pancreatitis in an elderly patient. There was no other evidence suggesting any other etiology of pancreatitis for this patient. According to the Naranjo Adverse Drug Reaction Probability Scale, the association of pancreatitis is a probable reaction due to aspirin/dipyridamole.2 Although rare, this severe complication illustrates how physicians and clinical pharmacists should be aware of the risk of pancreatitis with aspirin/dipyridamole and the consequences regarding secondary stroke prevention after it occurs.
Source: The American Journal of Medicine - November 17, 2019 Category: General Medicine Authors: Daniel J. DeSantis, Punam B. Patel, Ludmila Gerova, Derek W. Grady Tags: Diagnostic Dilemma Source Type: research
Oral anticoagulation in emergency department patients: high rates of off-label doses,no difference in bleeding rates
Patients with oral anticoagulation constitute an increasing proportion in the present medical routine.1 The approval of the first direct oral anticoagulant (DOAC) dabigatran by the U.S. food and drug administration in 2010 for the purpose of stroke prevention in patients with non-valvular atrial fibrillation revolutionized the therapy strategies of this entity since the Vitamin-K antagonists (VKA) warfarin, phenprocoumon and acenocoumarol had been the only available oral anticoagulants for decades.
Source: The American Journal of Medicine - October 23, 2019 Category: General Medicine Authors: Corinne M. Eschler, Bertram K. Woitok, Georg-Christian Funk, Philipp Walter, Volker Maier, Aristomenis K. Exadaktylos, Gregor Lindner Tags: Clinical Research Study Source Type: research
Predictors of not initiating anticoagulation after incident venous thromboembolism: a Danish nationwide cohort study
Venous thromboembolism, com prising deep vein thrombosis and pulmonary embolism, is the third most common cause of cardiovascular death after stroke and myocardial infarction.1 Anticoagulation is the keystone in venous thromboembolism treatment and prevention of venous thromboembolism morbidity, mortality, and recurrence. International guidelines mandate anticoagulant therapy for a minimum of 3 months after proximal deep vein thrombosis and/or pulmonary embolism.2,3
Source: The American Journal of Medicine - October 9, 2019 Category: General Medicine Authors: Ida Ehlers Albertsen, Samuel Zachary Goldhaber, Gregory Piazza, Thure Filskov Overvad, Peter Br ønnum Nielsen, Torben Bjerregaard Larsen, Mette Søgaard Tags: Clinical Research Study Source Type: research
The Effect of Preexisting Anticoagulation on Cerebrovascular Events in Left-Sided Infective Endocarditis
The objective of this study was to evaluate the effect of anticoagulation on stroke occurrence and bleeding complications in patients with left-sided infective endocarditis.
Source: The American Journal of Medicine - September 4, 2019 Category: General Medicine Authors: Kyle A. Davis, Glen Huang, S. Allan Petty, Walter A. Tan, Diego Malaver, James E. Peacock Tags: Clinical Research Study Source Type: research
The effect of pre-existing anticoagulation on cerebrovascular events in left-sided infective endocarditis
The objective of this study was to evaluate the effect of anticoagulation on stroke occurrence and bleeding complications in patients with left-sided infective endocarditis.
Source: The American Journal of Medicine - September 4, 2019 Category: General Medicine Authors: Kyle A. Davis, Glen Huang, S. Allan Petty, Walter A. Tan, Diego Malaver MSA, James E. Peacock Tags: Clinical Research Study Source Type: research
Postoperative Atrial Fibrillation Following Noncardiac Surgery Increases Risk of Stroke
New-onset postoperative atrial fibrillation is well recognized to be an adverse prognostic marker in patients undergoing noncardiac surgery. Whether postoperative atrial fibrillation confers an increased risk of stroke remains unclear.
Source: The American Journal of Medicine - August 29, 2019 Category: General Medicine Authors: Anoop N. Koshy, Garry Hamilton, James Theuerle, Andrew W. Teh, Hui-Chen Han, Paul J. Gow, Han S. Lim, Vincent Thijs, Omar Farouque Tags: Clinical Research Study Source Type: research
Post-operative Atrial Fibrillation following Noncardiac Surgery Increases Risk of Stroke
New-onset post-operative atrial fibrillation is well recognized to be an adverse prognostic marker in patients undergoing noncardiac surgery. Whether post-operative atrial fibrillation confers an increased risk of stroke remains unclear.
Source: The American Journal of Medicine - August 29, 2019 Category: General Medicine Authors: Anoop N. Koshy, Garry Hamilton, James Theuerle, Andrew W Teh, Hui-Chen Han, Paul J. Gow, Han S Lim, Vincent Thijs, Omar Farouque Tags: Clinical Research Study Source Type: research
