Filtered By:
Source: The American Journal of Medicine
Condition: Stroke

This page shows you your search results in order of date. This is page number 11.

Order by Relevance | Date

Total 256 results found since Jan 2013.

Preclinical and Clinical Data for Factor Xa and “Universal” Reversal Agents
Oral Factor Xa (FXa) inhibitors, a growing class of direct-acting anticoagulants, are frequently used to prevent stroke and systemic embolism in patients with atrial fibrillation and to prevent and treat venous thromboembolism. These drugs reduce the risk of clotting at the expense of increasing the risk of bleeding, and currently they have no specific reversal agent. However, andexanet  alfa, a recombinant modified FXa decoy molecule, is in a late-phase clinical trial in bleeding patients, and ciraparantag, a small molecule that appears to reverse many anticoagulants including the FXa inhibitors, is in development.
Source: The American Journal of Medicine - August 26, 2016 Category: Journals (General) Authors: Truman J. Milling, Scott Kaatz Tags: Review Source Type: research

Safety of Direct Oral Anticoagulants: Insights from Postmarketing Studies
Direct oral anticoagulants (DOACs) have been marketed in the United States since 2010. While numerous large-scale prospective phase 3 outcomes studies have documented the effectiveness of DOACs for the prevention of stroke and systemic embolism in patients with nonvalvular atrial fibrillation, the primary safety concern with all of these drugs —as it is with the more established oral anticoagulant warfarin—is the risk of major bleeding. Postmarketing surveillance studies (PMSS) provide the opportunity to evaluate the safety of these recently approved drugs across a spectrum of patients that may be broader than those in...
Source: The American Journal of Medicine - August 25, 2016 Category: Journals (General) Authors: Todd C. Villines, W. Frank Peacock Tags: Review Source Type: research

Cryptogenic Strokes and Patent Foramen Ovales: What's the Right Treatment?
More than 25% of all ischemic strokes per year are cryptogenic, that is, their cause is not determined after an appropriate evaluation. In 1988, it was reported that the incidence of a patent foramen ovale was 30 to 40% in young patients with a cryptogenic stroke compared with 25% in the general population. This led to the suspicion that cryptogenic strokes were due to paradoxical embolism, that is, a venous thrombus crossing a patent foramen ovale to enter the left atrium and then the arterial circulation.
Source: The American Journal of Medicine - August 22, 2016 Category: Journals (General) Authors: James E. Dalen, Joseph S. Alpert Tags: Review Source Type: research

Cryptogenic Strokes and Patent Foramen Ovales: What ’s The Right Treatment?
More than 25% of all ischemic strokes per year are cryptogenic; that is their cause is not determined after an appropriate evaluation.In 1988 it was reported that the incidence of a patent foramen ovale (PFO) was 30 to 40% in young patients with a cryptogenic stroke compared to 25% in the general population. This led to the suspicion that cryptogenic strokes were due to paradoxical embolism; that is a venous thrombus crossing a patent foramen ovale to enter the left atrium and then the arterial circulation.
Source: The American Journal of Medicine - August 22, 2016 Category: Journals (General) Authors: James E. Dalen, Joseph S. Alpert Tags: Review Source Type: research

The Reply
The authors thank Xue et al for their interest in our article titled “Association between Anemia, Bleeding, and Transfusion with Long-Term Mortality Following Non-Cardiac Surgery.”1 We share the authors' concern about the potential for residual confounding in this observational analysis of a large single-center surgical database. The initial analysis adjusted for age, sex, race, elective vs emergency/urgent surgery, procedure type, and the individual components of the Revised Cardiac Risk Index including coronary artery disease, heart failure, stroke/transient ischemic attack, creatinine>2 mg/dL, and diabetes mellitus.
Source: The American Journal of Medicine - August 21, 2016 Category: Journals (General) Authors: Nathaniel R. Smilowitz, Jeffrey S. Berger Tags: AJM online Source Type: research

From Leptin, DEXA, and Beyond
Kahn and Bullard “recommend that waist circumference be added to BMI [body mass index] as a primary tool for assessing adiposity.”1 Suggesting “a need for alternative approaches to anthropometry”1 is necessary because BMI incorrectly classifies obesity by 39%.2 Many adults are obese by American Society of Ba riatric Physicians criteria of body fat: ≥25% for men and ≥30% for women.3 Normal-weight obese adults have increased mortality risk from diabetes, hypertension, heart disease, stroke, cancer, dyslipidemia, liver and gallbladder disease, sleep apnea and respiratory problems, and osteoarthritis.
Source: The American Journal of Medicine - July 28, 2016 Category: Journals (General) Authors: Eric R. Braverman Tags: AJM online Source Type: research

The Limited Public Health Impact of ‘Lifestyle’ Change
Two main factors are responsible for premature disease and mortality. One is smoking, often referred to as a “lifestyle choice,” but better described as a “habit.” The other is poor nutrition resulting largely from the sugar, alcohol, salt, and saturated fat content (SASS components) of ready-to-consume food and drink, much of which is manufactured on an industrial scale. Collectively, these dietar y components are the main drivers of the global epidemic of stroke, heart attack, obesity, and type 2 diabetes.
Source: The American Journal of Medicine - July 14, 2016 Category: Journals (General) Authors: Nicholas J. Wald Tags: Editorial Source Type: research

The limited public health impact of “lifestyle” change
Two main factors are responsible for premature disease and mortality. One is smoking, often referred to as a “lifestyle choice”, but better described as a “habit”. The other is poor nutrition resulting largely from the sugar, alcohol, salt, and saturated fat content (SASS components) of ready to consume food and drink, much of which is manufactured on an industrial scale. Collectively these dietary components are the main drivers of the global epidemic of stroke, heart attack, obesity, and type 2 diabetes.
Source: The American Journal of Medicine - July 14, 2016 Category: Journals (General) Authors: Nicholas J. Wald Tags: Editorial Source Type: research

The Call for a Physical Activity Vital Sign in Clinical Practice
According to the Bureau of Labor Statistics, the most common shared occupational health risk is sedentary behavior. Physical inactivity increases the relative risk of coronary artery disease, stroke, hypertension and osteoporosis by 45%, 60%, 30%, and 59% respectively.1 Epidemiologic data suggest that physical inactivity is associated with an increased risk of 25 chronic diseases.2 Due to the fact that approximately 90% of American adults do not meet current physical activity guidelines,5 deaths attributable to physical inactivity may soon exceed those attributed to cigarette smoking,3,4 For these reasons, physical inactiv...
Source: The American Journal of Medicine - May 23, 2016 Category: Journals (General) Authors: Robert E. Sallis, Aaron L. Baggish, Barry A. Franklin, James R. Whitehead Tags: Commentary Source Type: research

Unmasking a Hidden Cause of Persistent Facial Ulceration: The Relevancy of a Neurologic Examination
A 49-year-old woman presented to the Emergency Department of a tertiary medical center for evaluation of chronic facial ulceration. Her past medical history was significant for type II diabetes mellitus, hypothyroidism, antiphospholipid antibody syndrome, venous thromboembolism, and stroke. The patient noted progressive ulceration around the left nasal ala with extension to the left eyebrow and eyelid for 2 years. She had been evaluated for this problem numerous times at outside medical facilities.
Source: The American Journal of Medicine - May 19, 2016 Category: Journals (General) Authors: Kyle W. Mahoney, Jules B. Lipoff, Bennett W. Clark Tags: Diagnostic dilemma Source Type: research

Prevalence and significance of unrecognized renal dysfunction in patients with stroke
Unrecognized renal dysfunction, defined as estimated glomerular filtration rate
Source: The American Journal of Medicine - May 19, 2016 Category: Journals (General) Authors: David Pereg, Zach Rozenbaum, Dina Vorobeichik, Nir Shlomo, Ronit Gilad, Sivan Bloch, Morris Mosseri, David Tanne Tags: Clinical Research Study Source Type: research

Unmasking a Hidden Cause of Persistent Facial Ulceration The Relevancy of a Neurologic Examination
A 49-year-old woman presented to the emergency room of a tertiary medical center for evaluation of chronic facial ulceration. Her past medical history was significant for type II diabetes mellitus, hypothyroidism, antiphospholipid antibody syndrome, venous thromboembolism, and stroke. The patient noted progressive ulceration around the left nasal ala with extension to the left eyebrow and eyelid for 2 years. She had been evaluated for this problem numerous times at outside medical facilities. Previous treatments included three 6-week courses of intravenous vancomycin, one 6-week course of daptomycin, and one 2-week course of oral acyclovir.
Source: The American Journal of Medicine - May 19, 2016 Category: Journals (General) Authors: Kyle W. Mahoney, Jules B. Lipoff, Bennett W. Clark Tags: Diagnostic Dilemma Source Type: research