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Source: Neurology
Therapy: Stem Cell Therapy
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Total 16 results found since Jan 2013.
Diffusion Tensor Imaging of Corticospinal Tract Recovery after Intra-arterial Mesenchymal Stem Cell Infusion in a Canine Stroke Model (P1.266)
Conclusions:Serial DTI-DTT imaging after IA MSCs therapy in large animal stroke model appears to have a trend towards higher change in FA. These findings could support further development of DTI-DTT biomarkers to measure neurologic recovery in experimental models as well as early clinical trials of novel stroke therapies.Disclosure: Dr. Guada has nothing to disclose. Dr. Pattany has nothing to disclose. Dr. Ramdas has nothing to disclose. Dr. Atchaneeyasakul has nothing to disclose. Dr. Saigal has nothing to disclose. Dr. Yavagal has received personal compensation for activities with Medtronic and Guidepoint as a consultant.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Guada, L., Pattany, P., Ramdas, K., Atchaneeyasakul, K., Saigal, G., Yavagal, D. Tags: Genetic Stroke Syndromes, Biomarkers, and Translational/Basic Research Source Type: research
Intra-Arterial Mesenchymal Stem Cells in a Large Animal Endovascular Canine Stroke Model: Findings on Serial Diffusion Tensor Imaging (S42.007)
Conclusions: Serial DTI-DTT imaging after IA cell therapy shows improvement in white matter tracts correlating with neurologic recovery. This supports further development of DTI-DTT biomarkers to measure neurologic recovery in experimental models as well as early clinical trials.Disclosure: Dr. Guada has nothing to disclose. Dr. Pattany has nothing to disclose. Dr. Ramdas has nothing to disclose. Dr. Yavagal has received personal compensation for activities with Covidien/evV3 as a consultant and Steering Committee Member.
Source: Neurology - February 7, 2016 Category: Neurology Authors: Guada, L., Pattany, P., Ramdas, K., Yavagal, D. Tags: Stroke Mechanism and Modifiers Source Type: research
Intra-arterial ALD401 Cell Therapy Is Associated with Reduction in Stroke Volume at 90 Days in a Subset of the RECOVER-Stroke Trial (P6.004)
Conclusions: In this exploratory analysis from one center in the multi-center RECOVER-Stroke trial, intra-arterial stem cell injection with ALD-401 was associated with significant reduction in stroke volume at 90 days post therapy compared to sham procedure in subacute ischemic stroke patients.Disclosure: Dr. Atchaneeyasakul has nothing to disclose. Dr. Dharmadhikari has nothing to disclose. Dr. Sidani has nothing to disclose. Dr. Ramdas has nothing to disclose. Dr. Delgado has nothing to disclose. Dr. Pafford has nothing to disclose. Dr. Huang has received personal compensation for activities with Aldagen/Cytomedix and Da...
Source: Neurology - April 3, 2016 Category: Neurology Authors: Atchaneeyasakul, K., Dharmadhikari, S., Sidani, C., Ramdas, K., Delgado, L., Pafford, R., Huang, D., Hinson, J., Savitz, S., Yavagal, D. Tags: Cerebrovascular Disease and Interventional Neurology Poster Discussion Session Source Type: research
Predictive Risk Factors of In-Hospital Mortality Following Acute Stroke in the United States: Data from the Nationwide Inpatient Database, 2006-2010 (P02.015)
CONCLUSIONS: The rate of in-hospital mortality is relatively high following acute stroke (8.42%). We identified multiple risk factors of in-hospital mortality in acute stroke patients. The strongest risk factor is the type stroke (hemorrhagic). The present finding suggests that patients at increased risk of mortality can be identified and additional treatment for prevention might be warranted.Disclosure: Dr. Naderi has nothing to disclose. Dr. Abcede has nothing to disclose. Dr. Al-Khoury has nothing to disclose. Dr. Mozaffar has received personal compensation for activities with California Stem Cell Inc., NuFactor, Cresce...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Naderi, N., Abcede, H., Al-Khoury, L., Mozaffar, T., Jain, V. Tags: P02 Cerebrovascular Disease II Source Type: research
DTI Analysis of the Corticospinal Tracts in Clinical Trial of Intra- Arterial Stem Cell Therapy for Stroke (P3.302)
Conclusions: In this exploratory analysis from one center in the multi-center RECOVER-Stroke trial, intra-arterial stem cell injection with ALD-401 was not associated with significant difference among groups in regards to DTI analysis except for qualitative assessment on tractography. Further DTI-analysis of subsequent visits up to one year needs to be done.Disclosure: Dr. Guada has nothing to disclose. Dr. Atchaneeyasakul has nothing to disclose. Dr. Pattany has nothing to disclose. Dr. Rodriguez has nothing to disclose. Dr. Ramdas has nothing to disclose. Dr. Yavagal has received personal compensation for activities with...
Source: Neurology - April 3, 2016 Category: Neurology Authors: Guada, L., Atchaneeyasakul, K., Pattany, P., Rodriguez, J., Ramdas, K., Yavagal, D. Tags: Neurorehabilitation Source Type: research
A Randomized Control Trial of Granulocyte Colony Stimulating Factor (G-CSF) Intervention in Acute Ischemic Stroke to Improve Functional Outcome (P1.139)
Conclusions: Endogenous mobilization of bonemarrow hematopoietic stem cells by GCSF administration perhaps leads to better functional outcome. This study provides preliminary evidence of potential safety, feasibility, and tolerability of G-CSF therapy in patients with acute ischaemic stroke. The safety and modest efficacy demonstrated in this study augurs for further studies with a larger sample sizes and longer follow ups.Disclosure: Dr. Gorthi has nothing to disclose. Dr. Nauwhar has nothing to disclose. Dr. Gupta has nothing to disclose. Dr. Hassan has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Gorthi, S., Nauwhar, D., Gupta, P., Hassan, K. Tags: Cerebrovascular Disease and Interventional Neurology: Rehabilitation and Recovery Source Type: research
Factors Determining Consent in a Randomized Trial of Intra-arterial Stem Cell Therapy for Sub-Acute Ischemic Stroke (P2.386)
Conclusions: There was a relatively high rate of consent among eligible patients in the first US intra-arterial trial of stem cell therapy for stroke. Approaching LAR for consent was found not to influence consenting rates.Disclosure: Dr. Ramdas has nothing to disclose. Dr. Pafford has nothing to disclose. Dr. Haussen has nothing to disclose. Dr. McBee has nothing to disclose. Dr. Rutledge has nothing to disclose. Dr. Huang has received personal compensation for activities with Aldagen/Cytomedix and Dart Neuroscience as a consultant. Dr. Savitz has received research support from NIH T32 grant. Dr. Hinson has nothing to dis...
Source: Neurology - April 3, 2016 Category: Neurology Authors: Ramdas, K., Pafford, R., Haussen, D., McBee, D., Rutledge, J., Huang, D., Savitz, S., Hinson, J., Yavagal, D. Tags: Research Methodology and Patient Education Source Type: research
Electrical Stimulation of Neural Stem Cells Improves Stroke Recovery (P1.005)
Conclusions: Our results show that electrically preconditioned NSCs enhance stroke recovery. Gene expression of the thrombospondins (a family of matricellular proteins thought to be involved with angiogenesis and inflammation) and VEGF (proteins critical to angiogenesis) were found to be modified by electrically stimulating NSCs, suggesting possible mechanisms for functional recovery.Disclosure: Dr. George has nothing to disclose. Dr. Bliss has nothing to disclose. Dr. Mehta has nothing to disclose. Dr. Hua has nothing to disclose. Dr. Sun has nothing to disclose. Dr. Steinberg has received personal compensation for activi...
Source: Neurology - April 8, 2015 Category: Neurology Authors: George, P., Bliss, T., Mehta, S., Hua, T., Sun, G., Steinberg, G. Tags: Cerebrovascular Disease and Interventional Neurology Poster Discussion Session Source Type: research
Effects of Intra-Arterial Delivery of Mesenchymal Stem Cells on Infarct Size and Neurological Outcome in Rat Middle Cerebral Artery Occlusion Model: A Systematic Review and Meta-analysis (P4.216)
Conclusions:Meta-analysis of IA MSCs studies showed significantly improvement in mNSS and reduction of infarct volume in rat MCAO model at 7 and 14 days after treatment compared to control with saline/PBS/no treatment. Lower effect size was seen at 28 days. Larger effect size was also seen in subgroup receiving therapy <24 hours after stroke onset. Early clinical trials of this novel approach are hence well supported.Disclosure: Dr. Atchaneeyasakul has nothing to disclose. Dr. Watanabe has nothing to disclose. Dr. Zhang has nothing to disclose. Dr. Lord has nothing to disclose. Dr. Guada has nothing to disclose. Dr. Bha...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Atchaneeyasakul, K., Watanabe, M., Zhang, T., Lord, S., Guada, L., Bhattacharya, P., Ramdas, K., Raval, A., Dong, C., Rundek, T., Yavagal, D. Tags: Neuro-rehabilitation: Mechanism of Recovery Source Type: research
Neural Stem Cell Therapy in the Ischemic Brain (P02.022)
CONCLUSIONS: Intracranial transplantation of neural stem cells into a C57BL6 mouse model of stroke preserved motor function and reduced pathology including downregulation of proinflammatory cytokines.Disclosure: Dr. Lee has nothing to disclose. Dr. Huang has nothing to disclose.
Source: Neurology - February 14, 2013 Category: Neurology Authors: Lee, J.-P., Huang, L. Tags: P02 Cerebrovascular Disease II Source Type: research
Co-Expression Networks In Generation Of Induced Pluripotent Stem Cells (iPSCs) (P1.047)
CONCLUSIONS: The use of a novel reprogramming method, which enabled highly synchronized reprogramming, identified unique biological networks that are vital to our understanding of iPSC generation. These networks identified pathways, hub genes and transcription factors, which are candidates for follow-up studies.Study Supported by: This work was supported by Grants RO1NS33123 and RC4NS073009 from the National Institutes of Neurological Disorders and Stroke to SMP.Disclosure: Dr. Pflieger has nothing to disclose. Dr. Paul has nothing to disclose. Dr. Gao has nothing to disclose. Dr. Coppola has nothing to disclose. Dr. Pulst...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Pflieger, L., Paul, S., Gao, F., Coppola, G., Pulst, S. Tags: Movement Disorders: Basic Mechanisms Source Type: research
Development of a Modified Central Nervous System Extracelluar Matrix with Polylysine. (P1.276)
Conclusion: Our data demonstrate proof of principle that modification of CNS-ECM with polylysine significantly improves neuron-ECM interaction. These preliminary data suggest that additional studies are warranted to further evaluate the affect of polylyine modified CNS-ECM on neurons.Disclosure: Dr. Marrotte has nothing to disclose. Dr. Zaher has nothing to disclose. Dr. Zhang has nothing to disclose. Dr. Chopp has received personal compensation for activities with EVER Pharmaceutical and Johnson & Johnson. Dr. Chopp has received license fee payments from RegenRx. Dr. Buller has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Marrotte, E., Zaher, N., Zhang, Y., Chopp, M., Buller, B. Tags: Neural Repair and Neuro-rehabilitation: Basic Science Source Type: research
Glioproliferative Lesion of the Spinal Cord Derived from Intrathecal Administration of Stem Cells (P4.234)
CONCLUSIONS: Unregulated intrathecal SCT can cause devastating complications. This patient’s highly proliferative neoplasm developing from pluripotent stem cells supports the ideological shift to employ more differentiated cells in future SCT research.Disclosure: Dr. Saad has nothing to disclose. Dr. Miller has nothing to disclose. Dr. Cagney has nothing to disclose. Dr. Chavakula has nothing to disclose. Dr. Guleria has nothing to disclose. Dr. Aizer has nothing to disclose. Dr. Ligon has nothing to disclose. Dr. Chi has nothing to disclose. Dr. Berkowitz has received royalty payments from Clinical Pathophysiology M...
Source: Neurology - April 3, 2016 Category: Neurology Authors: Saad, M., Miller, M., Cagney, D., Chavakula, V., Guleria, I., Aizer, A., Ligon, K., Chi, J., Berkowitz, A. Tags: Neuro-oncology: Neurologic Complications of Cancer Source Type: research
Intra-Arterial Stem Cell Therapy for a Persistent Vegetative State Patient: A DTI Analysis of Recovery (P6.066)
Conclusion Assessing minor neurological improvements in this patient remains challenging but advances in neuroimaging as an evaluating tool helps to detect those changes. Future assessments and imaging will be performed to better clarify the findings mentioned above.Disclosure: Dr. Ramdas has nothing to disclose. Dr. Guada has nothing to disclose. Dr. Pafford has nothing to disclose. Dr. Haussen has nothing to disclose. Dr. Pattany has nothing to disclose. Dr. Yavagal has received personal compensation for activities with Covidien/evV3 as a consultant and Steering Committee Member.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Ramdas, K., Guada, L., Pafford, R., Haussen, D., Pattany, P., Yavagal, D. Tags: Cerebrovascular Disease: Miscellaneous Interventions Source Type: research
Ethical clinical translation of stem cell interventions for neurologic disease
The application of stem cell transplants in clinical practice has increased in frequency in recent years. Many of the stem cell transplants in neurologic diseases, including stroke, Parkinson disease, spinal cord injury, and demyelinating diseases, are unproven—they have not been tested in prospective, controlled clinical trials and have not become accepted therapies. Stem cell transplant procedures currently being carried out have therapeutic aims, but are frequently experimental and unregulated, and could potentially put patients at risk. In some cases, patients undergoing such operations are not included in a clin...
Source: Neurology - January 15, 2017 Category: Neurology Authors: Cote, D. J., Bredenoord, A. L., Smith, T. R., Ammirati, M., Brennum, J., Mendez, I., Ammar, A. S., Balak, N., Bolles, G., Esene, I. N., Mathiesen, T., Broekman, M. L. Tags: Parkinson's disease/Parkinsonism, All Ethics in Neurology/Legal issues, Malpractice, Error in medicine, Professional conduct and ethics CONTEMPORARY ISSUES Source Type: research
