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Elevated cerebrospinal fluid total Tau levels reflects predominant cortical involvement in Alzheimers disease (P1.093)
Conclusions:Elevated CSF Tau levels in AD patients could be surrogate biomarker for AD subtypes with predominant early cortical symptoms and atrophy. There is a need for a systematic prospective unbiased follow-up to see if rapid clinical progression in AD is related to elevated T-Tau and distinct AD subtypes.Disclosure: Dr. Pillai has nothing to disclose. Dr. Khrestian has nothing to disclose. Dr. Bekris has nothing to disclose. Dr. Safar has nothing to disclose. Dr. Leverenz has received personal compensation for activities with Axovant, GE Healthcare and Navidea Biopharmaceuticals as a consultant.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Pillai, J., Khrestian, M., Bekris, L., Safar, J., Leverenz, J. Tags: Aging and Dementia: Biomarkers Source Type: research

Sporadic Creutzfeldt-Jakob Disease Presenting as Non-Convulsive Status Epilepticus: A Case Report (P1.333)
CONCLUSIONS: Non-convulsive status epilepticus is an extremely rare presentation of prion disease. To date, there have only been three reported cases in the literature. This case highlights the need to consider prion disease as an etiology in NCSE and NORSE.Disclosure: Dr. Alobaidy has nothing to disclose. Dr. Parker has nothing to disclose. Dr. Bershad has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Alobaidy, A., Parker, A., Bershad, E. Tags: Fungal and Other Infectious Disorders Source Type: research

Creutzfeldt-Jakob Disease Presenting as Stroke: Case Report and Literature Review (P1.022)
CONCLUSIONS CJD develops primarily within a population in whom stroke risk factors are common and represents a rare but important stroke mimic. Negative sensitive imaging in elderly patients with apparent acute vascular syndromes should prompt diagnostic review including consideration of prion diseases.Disclosure: Dr. Van Heuven has nothing to disclose. Dr. Boggild has nothing to disclose. Dr. White has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Van Heuven, A., Boggild, M., White, R. Tags: Cerebrovascular Disease and Interventional Neurology: Case Reports Source Type: research

Voltage Gated Calcium Channels Antibody-Associated Autoimmune Encephalitis (P5.228)
ConclusionThis case demonstrates a correlation between a high titer of VGCC antibodies and autoimmune encephalitis. Our patient's initial improvement with steroids and plasma exchange in the face of a negative CT and PET suggests a primary autoimmune process rather than a paraneoplastic etiology, though we admit that it is premature to rule out remission and we will continue to follow herDisclosure: Dr. Alwaki has nothing to disclose. Dr. Lugo has nothing to disclose. Dr. Goshgarian has nothing to disclose. Dr. Ahmad has nothing to disclose. Dr. Hefzy has nothing to disclose. Dr. Mitsias has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Alwaki, A., Lugo, A., Goshgarian, C., Ahmad, O., Hefzy, H., Mitsias, P. Tags: Aging, Dementia, and Cognitive and Behavioral Neurology: Creutzfeldt-Jakob Disease and Subacute Encephalopathies Source Type: research

Corticobasal syndrome associated with antiphospholipid syndrome without cerebral infarction
Antiphospholipid syndrome (APS) is a rare autoimmune coagulopathy with various systemic and neurologic symptoms. Ischemic stroke and TIA are common neurologic manifestations of APS, while migraine, epilepsy, chorea, and multiple sclerosis–like syndromes have also been reported.1,2 Dementia is an unusual manifestation of APS, and the presentation of APS with corticobasal syndrome (CBS) has rarely been reported.3,4 CBS is a progressive neurologic syndrome characterized by asymmetric cortical dysfunction, such as apraxia, alien limb phenomenon, or cortical sensory changes accompanied by akineto-rigid syndrome or dystoni...
Source: Neurology - February 24, 2014 Category: Neurology Authors: Lee, D.-W., Eum, S.-W., Moon, C. O., Ma, H.-I., Kim, Y. J. Tags: All Medical/Systemic disease, Corticobasal degeneration CLINICAL/SCIENTIFIC NOTES Source Type: research