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Trends and Characteristics of Tuberculous Meningitis in the United States, 1993-2013 (S30.007)
Conclusions:Over the past two decades, the incidence and mortality of TBM in the US have steadily declined, but neurological complications are increasing.Study Supported by:This work was supported by the National Institute of Neurological Disorders [grant numbers K23NS082367, R01NS097443-01 to H.K.] and the Michael Goldberg Stroke Research Fund to [H.K.].Disclosure: Dr. Merkler has nothing to disclose. Dr. Chatterjee has nothing to disclose. Dr. Gialdini has nothing to disclose. Dr. Reynolds has nothing to disclose. Dr. Morris has nothing to disclose. Dr. Murthy has nothing to disclose. Dr. Thakur has received personal com...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Merkler, A., Chatterjee, A., Gialdini, G., Reynolds, A., Morris, N., Murthy, S., Thakur, K., Kamel, H. Tags: Infectious Disease: HIV, Syphilis, Borrelia, TB, Cysticercosis, and Other Infections Source Type: research

A Rare Case of Central Nervous System Tuberculosis Presenting as Transient Splenial Lesion: Case Report and Literature Review (P1.320)
Conclusions:Based on literature review, the transient splenial lesion of corpus callosum has never been reported in patients with CNS tuberculosis. The mechanisms underlying transient splenial lesions may due to intramyelinic edema and inflammatory cell infiltration. This hypothesis supported by the MR spectroscopy findings in our patient. Since early diagnosis and treatment can reduce mortality and morbidity, patients with isolated splenial lesion warrant diagnostic tests for CNS tuberculosis.Study Supported by:The authors report no disclosures relevant to the manuscript.Disclosure: Dr. Wu has nothing to disclose. Dr. Che...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Wu, J.-W., Chen, S. Tags: Autoimmunity with Infection, Syphilis, Lyme, Tuberculosis, and other Bacteria Source Type: research

Burden of Cerebrovascular Disease and its association in the clinical characteristics, Incidence and outcomes in the hospitalized patients with Community-Acquired Pneumonia in Louisville, KY (P1.321)
Conclusions:This study documents worse clinical outcomes and significantly increased mortality in the hospitalized patients with community acquired pneumonia and associated cerebrovascular disease.Disclosure: Dr. SirDeshpande has nothing to disclose. Dr. Kolikonda has nothing to disclose. Dr. Peyrani has nothing to disclose. Dr. Ramirez has nothing to disclose. Dr. Arnold has nothing to disclose. Dr. Wiemken has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: SirDeshpande, P., Kolikonda, M., Peyrani, P., Ramirez, J., Arnold, F., Wiemken, T. Tags: Autoimmunity with Infection, Syphilis, Lyme, Tuberculosis, and other Bacteria Source Type: research

Streptococcus pneumoniae meningitis and intracranial vasculopathy: Clinical correlation with improving transcranial Doppler hemodynamics (P1.322)
Conclusions:Antibiotic treatment for S. pneumoniae meningitis correlated with improvement in clinical status and TCD hemodynamics. Serial TCDs may be a potentially useful strategy in the management of bacterial meningitis.Disclosure: Dr. Idris has nothing to disclose. Dr. Tai has nothing to disclose. Dr. Tan has nothing to disclose. Dr. Tan has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Idris, M. I., Tai, S. M. L., Tan, C. T., Tan, K. S. Tags: Autoimmunity with Infection, Syphilis, Lyme, Tuberculosis, and other Bacteria Source Type: research

Stroke and the noncommunicable diseases: A global burden in need of global advocacy
Catalyzed by advocacy in the early period of the global AIDS crisis, the past decades have witnessed a revolution in global health funding, programs, and outcomes. In 2011, global HIV/AIDS programs received $7.7 billion of development assistance, amounting to 25% of total global health funding. In comparison, all noncommunicable diseases (NCDs) combined received only $377 million or 1.2% of global health funding, 20-fold less than HIV/AIDS funding.1 Taken together, NCDs cause an estimated 66% of yearly global mortality.2 The percentage of estimated total global mortality due to stroke (11.3%), a single NCD, exceeds that of...
Source: Neurology - May 25, 2015 Category: Neurology Authors: Berkowitz, A. L. Tags: Stroke prevention, All Cerebrovascular disease/Stroke GLOBAL PERSPECTIVES Source Type: research

A Case Report of Rheumatoid Meningitis, an unusual complication of Rheumatoid Arthritis (P4.056)
CONCLUSIONS: Rheumatoid Meningitis is an extremely uncommon complication of Rheumatoid Arthritis. Initial presentations can vary from altered mental status (most common), cranial neuropathies, hemiparesis/paraparesis, seizure, headache and very rarely stroke like symptoms. This patient with Rheumatoid Arthritis presented with multiple stroke like episodes, lepomeningeal enhancement. Diagnosis was established on the basis of Imaging and Histopathology after excluding other potential causes of granulomatous meningitis. Study Supported by: Not applicableDisclosure: Dr. roy has nothing to disclose. Dr. Brink has nothing to dis...
Source: Neurology - April 8, 2015 Category: Neurology Authors: Roy, B., Brink, J., Bakradze, E., Al Zahmi, F., Uphoff, D., Silverman, I. Tags: MS and CNS Inflammatory Diseases: CNS Inflammatory Diseases and Differential Diagnosis Source Type: research

The Changing Epidemiology of Stroke in Acquired Immune Deficiency Syndrome (AIDS). (I7-1A)
Conclusions:There is an increased frequency of AIDS among stroke patients, possibly due to the increased detection of AIDS. In the HAART era, the median age of incident stroke in AIDS has increased. Whether HAART can reduce the incidence and improve survival of stroke needs to be explored.Disclosure: Dr. Kucab has received personal compensation for activities with Bayer HealthCare as an advisory board participant. Dr. Bhattacharya has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Kucab, P., Bhattacharya, P. Tags: The Global Burden of Neurological Infections: Epidemiology, Treatment, and Prevention Data Blitz Presentations Source Type: research

Myriad Manifestations of a Global Infectious Disease (I7-5A)
CONCLUSIONS: This case exhibits the myriad manifestations of tuberculosis in one patient; including meningitis, vasculitis, and tuberculomas. It also highlights that insular stroke in the non-dominant hemisphere could affect the cardiovascular-autonomic system.Disclosure: Dr. Prabhu has nothing to disclose. Dr. Raghupathi has nothing to disclose. Dr. Dissin has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Prabhu, A., Raghupathi, R., Dissin, J. Tags: The Global Burden of Neurological Infections: Epidemiology, Treatment, and Prevention Poster Presentations Source Type: research

The Changing Epidemiology of Stroke in Acquired Immune Deficiency Syndrome (AIDS). (P1.089)
Conclusions:There is an increased frequency of AIDS among stroke patients, possibly due to the increased detection of AIDS. In the HAART era, the median age of incident stroke in AIDS has increased. Whether HAART can reduce the incidence and improve survival of stroke needs to be explored.Disclosure: Dr. Kucab has received personal compensation for activities with Bayer HealthCare as an advisory board participant. Dr. Bhattacharya has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Kucab, P., Bhattacharya, P. Tags: Neuroepidemiology: Cerebrovascular Disease Source Type: research

The global burden of neurologic diseases
WHO categorizes causes of death and disability into (1) communicable diseases, maternal and perinatal conditions, and nutritional deficiencies; (2) non-communicable diseases (NCD); and (3) injuries. NCD are the leading cause of death and disability globally and are rising as a result of demographic and epidemiologic changes occurring in both developed and developing countries.1,2 Increasing life expectancies, unhealthy diet, physical inactivity, tobacco use, and harmful use of alcohol contribute to the growing incidence and prevalence of NCD, such as heart disease, stroke, diabetes, cancers, and chronic respiratory disease...
Source: Neurology - July 21, 2014 Category: Neurology Authors: Chin, J. H., Vora, N. Tags: All Cerebrovascular disease/Stroke, All epidemiology, All Epilepsy/Seizures GLOBAL PERSPECTIVES Source Type: research