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A Rare Neurological Complication of Waldenstroms Macroglobulinemia (P5.183)
Conclusions:Diagnostic approach to bilateral FNP should evaluate for: traumatic (skull fractures), infectious (classically Lyme disease), metabolic (diabetes), autoimmune (sarcoidosis, Guillain-Barré syndrome), congenital (Moebius syndrome) and neoplastic (brainstem tumors) entities. WM is a rare cause, a condition due to low-grade B cell lymphoma where lymphoplasmacytoid cells infiltrate different tissues and secrete monoclonal IgM. Peripheral neuropathy develops in 15–30% of the cases, usually a chronic, progressive, symmetric, predominantly distal polyneuropathy. Facial nerve impairment is unusual, caused b...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Acosta, G. T., Gadhia, R., Leslie-Mazwi, T. Tags: Neuro-oncology: Brain and CNS Metastases Source Type: research

AEDs after ICH: Preventing the prophylaxis
Has the routine use of antiepileptic drugs (AEDs) in intracerebral hemorrhage (ICH) become a habit too difficult to break? Adherents to evidence-based medicine must surely have a conniption in light of this continuing practice. The guidelines have remained clear over the years: Do not use antiseizure medications in ICH unless there has been a seizure. Yet prophylactic AED use after acute ICH remains widespread in the United States. This is brought to our attention in the current issue of Neurology®. Naidech et al.1 report on the patterns of AED use in ICH over 5 years across several academic medical centers in Chicago....
Source: Neurology - December 25, 2016 Category: Neurology Authors: Koch, S., Sung, G. Tags: Critical care, Antiepileptic drugs, Intracerebral hemorrhage EDITORIALS Source Type: research

Nursing Home Residents with Seizure Disorders/Epilepsy: Prevalence, Characteristics, and Treatment Patterns (P1.080)
Conclusions: NHRs with seizure disorder/epilepsy have substantial physical and cognitive impairment. Nearly half were prescribed combination AED therapy, and >20[percnt] took 蠅3 different AEDs, suggesting refractory epilepsy. Additional research is needed to assess treatment outcomes and further define optimal care in this population.Disclosure: Dr. Zarowitz has nothing to disclose. Dr. Allen has nothing to disclose. Dr. OShea has nothing to disclose. Dr. Wang has nothing to disclose. Dr. Semenchuk has nothing to disclose. Dr. Barghout has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Zarowitz, B., Allen, C., OShea, T., Wang, Z., Semenchuk, M., Barghout, V. Tags: Epilepsy/Clinical Neurophysiology: Geriatric Epilepsy, Epidemiology, and Health Services Source Type: research

Status Epilepticus in Patients with SMART (P5.012)
CONCLUSIONS We describe three patients with SMART presenting with SE. Our cases raise the concern that SMART is not necessarily a migraine phenomenon but can be a form of focal SE associated with stroke-like symptoms. In patients with radiographic suspicion of SMART we suggest a low threshold for vEEG monitoring and aggressive anti-epileptic management.Disclosure: Dr. Fan has nothing to disclose. Dr. Gabriel has nothing to disclose. Dr. Gerard has nothing to disclose. Dr. Schuele has received personal compensation for activities with Sunovion and Eisai as a speaker.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Fan, P., Gabriel, H., Gerard, E., Schuele, S. Tags: Neuromuscular Disease and Epilepsy ePoster Session Source Type: research

Demographics, Comorbidities and Clinical Features in Hospitalized Patients with Myoclonus (P3.022)
CONCLUSIONS: Myoclonus was particularly associated with renal impairment in the presence of a toxic exposure, most commonly opioids or anticonvulsants, and unlike patients with anoxia or hepatic impairment, more often featured a negative semiology.Disclosure: Dr. Ehrlich has nothing to disclose. Dr. Swan has nothing to disclose. Dr. Robbins has received personal compensation for activities with MedLink and Prova Education. Dr. Robbins has received personal compensation in an editorial capacity for Current Pain and Headache Reports. Dr. Herskovitz has nothing to disclose. Dr. Milstein has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Ehrlich, D., Swan, M., Robbins, M., Herskovitz, S., Milstein, M. Tags: Movement Disorders: Myoclonus, Paroxysmal Dyskinesias, and Parkinson ' s Disease Source Type: research

Antiepileptic Drug Prescribing for OEF/OIFVeterans with New-Onset Epilepsy: 2008-2010 (S59.004)
CONCLUSIONS: Our examination of prescribing patterns found that slightly over half of individuals with new epilepsy were treated using newer AEDs and 94% received monotherapy. Despite lack of FDA approval or recommendation by the AES, AAN or the ILAE for the use of levetiracetam monotherapy in the treatment of new onset epilepsy, levetiracetam monotherapy was the most common single medication prescribed. Moreover, nearly 40% of women in childbearing age received valproate or topiramate, which have been identified as teratogenic. Further research is needed to evaluate the quality of prescribing for women.Study Supported by:...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Pugh, M. J., Van Cott, A., Baca, C., Amuan, M. Tags: Epilepsy and Clinical Neurophysiology (EEG): Reproduction, Health Care Delivery, and Co-morbidities Source Type: research

Antiepileptic Drug Prescribing for OEF/OIFVeterans with New-Onset Epilepsy: 2008-2010 (I8-1.009)
CONCLUSIONS: Our examination of prescribing patterns found that slightly over half of individuals with new epilepsy were treated using newer AEDs and 94% received monotherapy. Despite lack of FDA approval or recommendation by the AES, AAN or the ILAE for the use of levetiracetam monotherapy in the treatment of new onset epilepsy, levetiracetam monotherapy was the most common single medication prescribed. Moreover, nearly 40% of women in childbearing age received valproate or topiramate, which have been identified as teratogenic. Further research is needed to evaluate the quality of prescribing for women.Study Supported by:...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Pugh, M. J., Van Cott, A., Baca, C., Amuan, M. Tags: Clinical Decision Making After the Dust Settles on Clinical Trials Poster Presentations Source Type: research

Epilepsy and Cancer: Ancient Problem in a Top Mortality Illness (P3.313)
CONCLUSIONS: Seizures in patients with cancer is a frequent comorbid condition with a high mortality rate, further studies are required to study the efficacy and security of AED and other forms of treatment.Study Supported by: NoneDisclosure: Dr. Cacho Diaz has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Cacho Diaz, B. Tags: Neurologic Complications of Cancer Source Type: research

Paroxysmal Dysarthria and Ataxia after Treatment of Brainstem Encephalitis (P6.053)
CONCLUSIONS: Paroxysmal dysarthria and ataxia is most often recognized as a complication of multiple sclerosis, but it can occur in other neurologic diseases with midbrain lesions near or involving the red nucleus. Effective treatments include carbamazepine, acetazolamide, lamotrigine, and phenytoin.Study Supported by: N/A.Disclosure: Dr. Klaas has nothing to disclose. Dr. Boes has nothing to disclose. Dr. Aksamit has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Klaas, J., Boes, C., Aksamit, A. Tags: Movement Disorders: Miscellaneous Ataxias Source Type: research

Epilepsia Partialis Continua Secondary To Ischemic Stroke, Responsive To The Combination Of Levetiracetam And Lacosamide (P4.255)
CONCLUSIONS: EPC represents a condition commonly refractory to AED. We report two cases of EPC secondary to subacute and chronic IS that showed responsiveness to the combination of levetiracetam and lacosamide. Further evaluation of this AED combination in treating this difficult condition is needed.Disclosure: Dr. Thompson has nothing to disclose. Dr. Murr has nothing to disclose. Dr. Fayad has received research support from the National Institute of Neurological Disorders and Stroke, and St Jude Medical.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Thompson, R., Murr, N., Fayad, P. Tags: Epilepsy and Clinical Neurophysiology (EEG): Status Epilepticus Source Type: research